Indian Journal of Neurotrauma 2004; 01(01): 23-26
DOI: 10.1016/S0973-0508(04)80022-4
Review Article
Thieme Medical and Scientific Publishers Private Ltd.

Coagulopathy Following Pediatric Head Injury and Its Importance In Predicting Outcome

Deepak Agrawal
,
AK Mahapatra

Subject Editor:
Further Information

Publication History

Publication Date:
05 April 2017 (online)

Abstract

Coagulopathy following pediatric head injury is not well known; in spite of its common occurrence following the injury and the fact that it may have a major prognostic role in the predicting the outcome of these children. The authors discuss the incidence, pathophysiology and management of coagulopathy in children with head injuries in light of the available literature and its usefulness in predicting outcome following head injury.

 
  • References

  • 1 Stein SC, Spettell CM. Delayed and progressive brain injury in children and adolescents with head trauma. Pediatr Neurosurg 23 1995; 299-304
  • 2 Michaud LJ, Rivara FP, Grady MS, Reay DT. Predictors of survival and severity of disability after severe brain injury in children. Neurosurgery 31 1992; 254-264
  • 3 Morenski JD, Tobias JD, Jimenez DF. Recombinant activated factor VII for cerebral injury-induced coagulopathy in pediatric patients. Report of three cases and review of the literature. J Neurosurg 98 2003; 611-616
  • 4 Chiaretti A, Piastra M, Pulitano S, Pietrini D, De Rosa G, Barbaro R, Di Rocco C. Prognostic factors and outcome of children with severe head injury: an 8-year experience. Childs Nerv Syst 18 2002; 129-136
  • 5 Chiaretti A, Pezzotti P, Mestrovic J, Piastra M, Polidori G, Storti S, Velardi F, Di Rocco C. The influence of hemocoagulative disorders on the outcome of children with head injury. Pediatr Neurosurg 34 2001; 131-137
  • 6 Keller MS, Fendya DG, Weber TR. Glasgow Coma Scale predicts coagulopathy in pediatric trauma patients. Semin Pediatr Surg 10 2001; 12-16
  • 7 Hymel KP, Abshire TC, Luckey DW, Jenny C. Coagulopathy in pediatric abusive head trauma. Pediatrics 99 1997; 371-375
  • 8 Kumura E, Sato M, Fukuda A, Takemoto Y, Tanaka S, Kohama A. Coagulation disorders following acute head injury. Acta Neurochir (Wien) 85 1987; 23-28
  • 9 Miner ME, Kaufman HH, Graham SH, Haar FH, Gildenberg PL. Disseminated intravascular coagulation fibrinolytic syndrome following head injury in children: frequency and prognostic implications. J Ped 100 1982; 687-691
  • 10 Selladurai BM, Vickneswaran M, Duraisamy S, Atan M. Coagulopathy in acute head injury — a study of its role as a prognostic indicator. Br J Neurosurg 11 1997; 398-404
  • 11 Jaap van der Sandle J, Veltkamp JJ, Boekhout-Mussert RJ, Bouwhuis-Hoogerwerf ML. Head injury and coagulation disorders. J Neurosurg 49 1978; 357-365
  • 12 Goodnight SH, Kenoyer G, Rapaport SI, Patch MJ, Lee JA, Kurze T. Defibrination after brain-tissue destruction: A serious complication of head injury. N Engl J Med 290 1974; 1043-1047
  • 13 Vecht CJ, Minderhoud JM, Sibinga CT. Platelet aggregability in relation to impaired consciousness after head injury. J Clin Pathol 28 1975; 814-820
  • 14 Kaufman HH, Mattson JC. Coagulopathy in head injury. In: Becker DP, Povlishock IT. (eds): Central Nervous System Trauma Status Report. 1985. William Byrd Press; Richmond: 187-206
  • 15 Olson JD, Kaufman HH, Moake J, O'Gorman TW, Hoots K, Wagner K, Brown CK, Gildenberg PL. The incidence and significance of hemostatic abnormalities in patients with head injuries. Neurosurgery 24 1989; 825-832
  • 16 Winter JP, Plummer D, Bottini A, Rockswold GR, Ray D. Early fresh frozen plasma prophylaxis of abnormal coagulation parameters in the severely head-injured patient is not effective. Ann Emerg Med 18 1989; 553-555
  • 17 Kaufman HH, Timberlake G, Voelker J, Pait TG. Medical complications of head injury. Med Clin North Am 77 1993; 43-60
  • 18 May AK, Young JS, Butler K, Bassam D, Brady W. Coagulopathy in severe closed head injury: is empiric therapy warranted?. Am Surg 63 1997; 233-236
  • 19 Gupta A, Mahapatra AK. Coagulation disorders after head injury. Pan Arab Journal of Neurosurgery 08 2004; 201-211
  • 20 Kaufman Hil, Moake JL, Olson JD, Miner ME, DuCret RP, Pruessner JL, Gildenberg PL. Delayed and recurrent intracranial hematomas related to disseminated intra-vascular clotting and fibrinolysis in head injury. Neurosurgery 07 1980; 445-449
  • 21 Takahashi H, Urano T, Takada Y, Nagai N, Takada A. Fibrinolytic parameters as an admission prognostic marker of head injury in patients who talk and deteriorate. Neurosurgery 86 1997; 768-772
  • 22 Vavilala MS, Dunbar PJ, Rivara FP, Lam AM. Coagulopathy predicts poor outcome following head injury in children less than l6 years of age. J Neurosurg Anesthesiol. 130 2001; 13-18
  • 23 Polin RS, Shaffrey ME, Phillips CD, Germanson T, Jane JA. Multivariate analysis and prediction of outcome following penetrating head injury. Neurosurg Clin N Am 06 1995; 689-699