Abstract
For 22 months we investigated the hemostatic status of 93 inpatients (44 male, and
49 female, average age 54.6 years) with a phlebographically objectified deep venous
thrombosis of the leg or iliac veins. Corresponding blood samples were taken before,
during, and after therapy. In 58 (62.4%) patients we found several kinds of disorders
of hemostasis. There were deficiencies of the protein C, protein S, factor XII, antithrombin
III, and the thrombocytes function. In most cases there was a single acquired deficiency
of one of these factors. Only in one patient (1.07%) could we verify an inherited
deficiency of factor XII. The most frequent disorder was a protein C deficiency in
32 (34.4%) patients. In 44 (47%) operatively treated patients we had postoperative
complications such as rethrombosis, phlegmasia coerulea dolens, or development of
skin necrosis during anticoagulant therapy in 12 (27.3%) cases. In 10 (83%) of these
patients with complications we had found preoperatively a disorder of hemostasis.
The statistical correlation between a preoperatively measured deficiency of the protein
C and the relapse of deep vein thrombosis was significant (p=0.0026).
