TY - ECHAP DO - 10.1055/sos-SD-211-00020 SN - 9783131728319 SN - 9783132064317 LA - EN AU - Shaabani,A.; Sarvary,A.; Shaabani,S. TI - 2.1.3 With Isocyanide Participation PB - Georg Thieme Verlag KG CY - Stuttgart PY - 2014 ET - 1st edition UR - http://www.thieme-connect.com/products/ebooks/lookinside/10.1055/sos-SD-211-00020 T3 - Science of Synthesis VL - 2013/6 DA - 2015/10/23 KW - isocyanides KW - α, β-unsaturated carbonyl compounds KW - dialkyl acetylenedicarboxylates KW - dipolar intermediates KW - dipolarophiles KW - heterocycles AB - Isocyanide-based multicomponent reactions represent a very important synthetic method for the synthesis of heterocyclic compounds with potential biological and medicinal activities. The nucleophilic property of isocyanides makes them a popular reactant class for the development of novel multicomponent reactions. One of the isocyanide-based multicomponent reaction approaches involves the generation of a dipolar intermediate by the addition of isocyanides to electron-deficient α, β-unsaturated carbonyl compounds such as dialkyl acetylenedicarboxylates; the dipolar intermediate can then be captured efficiently by various dipolarophiles such as CH-, NH-, and OH-acids, electron-deficient alkenes, and imines to form diverse cycloadducts. T2 - Multicomponent Reactions, Volume 2 ER -