3.2. 3.2 Natural-Product-Enriched DELs
Buch
Herausgeber: Scheuermann, J. ; Li, Y.
Titel: DNA-Encoded Libraries
Print ISBN: 9783132455221; Online ISBN: 9783132437357; Buch-DOI: 10.1055/b000000342
1st edition © 2024. Thieme. All rights reserved.
Georg Thieme Verlag KG, Stuttgart
Fachgebiete: Organische Chemie
Science of Synthesis Reference Libraries
Übergeordnete Publikation
Titel: Science of Synthesis
DOI: 10.1055/b-00000101
Reihenherausgeber: Fürstner, A. (Editor-in-Chief); Carreira, E. M.; Faul, M.; Kobayashi, S.; Koch, G.; Molander, G. A.; Nevado, C.; Trost, B. M.; You, S.-L.
Typ: Mehrbändiges Werk
Abstract
Natural products are privileged compounds of natural evolution that are often rich in sp3 carbon atoms, bear multiple stereocenters, and have diverse skeletons. These features endow natural products with a broad spectrum of pharmacological activities. As a consequence, natural products play a key role in the history of medical treatment and drug discovery. The natural-product-enriched DNA-encoded library (nDEL) approach allows natural products or bioactive chemical molecules with known biological functions to be readily annotated with unique amplifiable DNA barcodes by so-called “late-stage” DNA labeling reactions. The final DNA-annotated natural products are included in a DEL, which can be packaged in a single test-tube and screened against a broad spectrum of cellular targets.
Schlüsselwörter
DNA-encoded libraries - natural products - drug discovery - labeling - screening-
1 Koch MA, Schuffenhauer A, Scheck M, Wetzel S, Casaulta M, Odermatt A, Ertl P, Waldmann H. Proc. Natl. Acad. Sci. U. S. A. 2005; 102: 17272
-
3 Ma P, Xu H, Li J, Lu F, Ma F, Wang S, Xiong H, Wang W, Buratto D, Zonta F, Wang N, Liu K, Hua T, Liu Z, Yang G, Lerner RA. Angew. Chem. Int. Ed. 2019; 58: 9254
-
4 Xu H, Ma P, In: DNA-Encoded Chemical Libraries Israel D, Ding Y. 2541. Humana New York 2022; 81-87