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Cazin, C.  et al.: 2018 Science of Synthesis, 2016/5b: N-Heterocyclic Carbenes in Catalytic Organic Synthesis 2 DOI: 10.1055/sos-SD-224-00213
N-Heterocyclic Carbenes in Catalytic Organic Synthesis 2

2.7.4 Flow Systems for N-Heterocyclic Carbene Catalysis

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Book

Editors: Cazin, C. ; Nolan, S.

Authors: Basle, O.; Broggi, J.; Claver, C.; Clavier, H.; Collins, S. K.; Costabile, C.; Crevisy, C.; Crozet, D.; Davies, A.; Diesendruck, C. E.; Felten, S.; Godard, C.; Grela, K.; Holtz-Mulholland, M.; Jana, A.; Johnson, J.; Lapkin, A.; Liu, J.; Lombardía, A.; Louie, J.; Malecki, P.; Mauduit, M.; Munz, D.; Nelson, D.; Peñafiel, I.; Schmid, T.; Slugovc, C.; Smith, A. D.; Thieuleux, C.; Zhong, Y.

Title: N-Heterocyclic Carbenes in Catalytic Organic Synthesis 2

Print ISBN: 9783132414006; Online ISBN: 9783132414044; Book DOI: 10.1055/b-004-140260

1st edition © 2018 Georg Thieme Verlag KG
Georg Thieme Verlag, Stuttgart

Subjects: Organic Chemistry;Chemical Reactions, Catalysis;Organometallic Chemistry;Laboratory Techniques, Stoichiometry

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Parent publication

Title: Science of Synthesis

DOI: 10.1055/b-00000101

Series Editors: Carreira, E. M.; Decicco, C. P.; Fürstner, A.; Koch, G.; Molander, G.; Schaumann, E.; Shibasaki, M.; Thomas, E. J.; Trost, B. M.

Type: Multivolume Edition

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Abstract

Continuous-flow technology represents a paradigm shift in the manufacture of specialty chemicals and pharmaceuticals. In many such syntheses, catalysis by N-heterocyclic carbenes plays an important role due to the stability, activity, and broad synthetic utility of these species. This chapter explores the “sweet-spot” in the combination of catalysis by N-heterocyclic carbenes and flow-chemistry technology. The chapter opens with a description of the fundamentals of flow technology and then relates the functions of flow reactors to the specifics of N-heterocyclic carbene based catalysis. The chapter provides an overview of up-to-date literature on catalysis by carbenes in flow reactors.

Key words

continuous flow - flow chemistry - process intensification - N-heterocyclic carbenes - heterogenized catalysts
 
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