1.4.4 Enzymatic Synthesis of Amides

J. W. Schmidberger; L. J. Hepworth; A. P. Green; S. L. Flitsch

doi:10.1055/sos-SD-214-00250

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Faber, K. et al.: 2015 Science of Synthesis, 1: Biocatalysis in Organic Synthesis 1 DOI: 10.1055/sos-SD-214-00250

Biocatalysis in Organic Synthesis 1

1.4.4 Enzymatic Synthesis of Amides

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Editors: Faber, K.; Fessner, W.-D.; Turner, N. J.

Authors: Asano, Y.; Babich, L.; Bertau, M.; Cobucci-Ponzano, B.; Díaz-Rodríguez, A.; Engel, U.; Faber, K.; Flitsch, S. L.; Glueck, S. M.; Gotor-Fernández, V.; Green, A. P.; Hall, M.; Hartog, A. F.; Hepworth, L. J.; Hollmann, F.; Jeromin, G. E.; Lauchli, R.; Lavandera, I.; Liese, A.; Martínková, L.; Moracci, M.; Pesci, L.; Rodríguez-Mata, M.; Rozzell, D.; Rudat, J.; Schmidberger, J. W.; Servi, S.; Slomka, C.; Syldatk, C.; Tasnádi, G.; Tessaro, D.; Veselá, A. B.; Voglmeir, J.; Wever, R.

Title: Biocatalysis in Organic Synthesis 1

Print ISBN: 9783131741318; Online ISBN: 9783131975218; Book DOI: 10.1055/b-003-125815

1st edition © 2015. Thieme. All rights reserved.
Georg Thieme Verlag KG, Stuttgart

Subjects: Organic Chemistry

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Title: Science of Synthesis

DOI: 10.1055/b-00000101

Type: Multivolume Edition

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J. W. Schmidberger; L. J. Hepworth; A. P. Green; S. L. Flitsch

Abstract

The synthesis of amides is one of the most common reactions performed in organic chemistry. Biocatalysis is an attractive alternative to chemical methodologies because of the mild reaction conditions and excellent atom economy, combined with the potential for stereoselectivity. Here, we provide an overview of the literature on enzyme-catalyzed amide-bond formation on a preparative scale, with a focus on nonnatural substrates.

Key words

amines - amides - esters - aminolysis - enzymes - regioselectivity - chemoselectivity - stereoselectivity - kinetic resolution - lipases - esterases - penicillin acylases - proteases - nitrile hydratases

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