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Faber, K. et al.: 2015 Science of Synthesis, 1: Biocatalysis in Organic Synthesis 1 DOI: 10.1055/sos-SD-214-00002
Biocatalysis in Organic Synthesis 1

1.1.1 Historical Perspectives: Paving the Way for the Future

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Editors: Faber, K.; Fessner, W.-D.; Turner, N. J.

Authors: Asano, Y.; Babich, L.; Bertau, M.; Cobucci-Ponzano, B.; Díaz-Rodríguez, A.; Engel, U.; Faber, K.; Flitsch, S. L.; Glueck, S. M.; Gotor-Fernández, V.; Green, A. P.; Hall, M.; Hartog, A. F.; Hepworth, L. J.; Hollmann, F.; Jeromin, G. E.; Lauchli, R.; Lavandera, I.; Liese, A.; Martínková, L.; Moracci, M.; Pesci, L.; Rodríguez-Mata, M.; Rozzell, D.; Rudat, J.; Schmidberger, J. W.; Servi, S.; Slomka, C.; Syldatk, C.; Tasnádi, G.; Tessaro, D.; Veselá, A. B.; Voglmeir, J.; Wever, R.

Title: Biocatalysis in Organic Synthesis 1

Print ISBN: 9783131741318; Online ISBN: 9783131975218; Book DOI: 10.1055/b-003-125815

1st edition © 2015. Thieme. All rights reserved.
Georg Thieme Verlag KG, Stuttgart

Subjects: Organic Chemistry

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Parent publication

Title: Science of Synthesis

DOI: 10.1055/b-00000101

Type: Multivolume Edition

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Abstract

This chapter describes the evolution of modern biocatalysis, focusing on the application of both whole-cell biocatalysts and isolated enzymes in organic synthesis. Milestones in this process are the application to β-lactam and amino acid chemistry, the preparation of chiral synthons as single enantiomers for the synthesis of pharmaceutical intermediates, the modification of carbohydrates and the synthesis of value-added products from lipids. The application of hydrolytic enzymes (lipases, proteases, esterases, and nitrile hydratases) has evolved in time toward more complex enzymatic systems such as oxidoreductases involving cofactor recycling or aminotransferases (transaminases) leading to the formation of chiral amines. The recently developed techniques of molecular biology and directed evolution toward the preparation of better enzymatic catalysts are dramatically improving the availability and efficiency of the enzymes and thus significantly increasing the role of biocatalysis in organic synthesis.

Key words

chiral synthons - whole-cell biocatalysis - hydrolytic enzymes - oxidoreductases - cofactor recycling - directed evolution - cascade biocatalysis
 
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