2.5.6 Mannich-Type Reactions

P. Merino

Abstract

The nucleophilic addition of enolizable carbonyl compounds to imines and related derivatives such as iminium salts, nitrones, oximes, and hydrazones provides direct access to β-amino carbonyl derivatives. This reactivity has been employed in efficient approaches to the synthesis of enantiomerically pure compounds.

Schlüsselwörter

carbonyl compounds - enolates - hydrazones - imines - iminium salts - Mannich bases - Mannich reaction - nitrones - oximes

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