2.5. 6 Mannich-Type Reactions
Book
Editor: van Leeuwen, P. W. N. M.
Title: C-1 Building Blocks in Organic Synthesis 2
Subtitle: Alkenations, Cross Couplings, Insertions, Substitutions, and Halomethylations
Print ISBN: 9783131751218; Online ISBN: 9783132064515; Book DOI: 10.1055/b-003-125817
2014 © 2014. Thieme. All rights reserved.
Georg Thieme Verlag KG, Stuttgart
Subjects: C-1 Building Blocks in Organic Synthesis
Science of Synthesis Reference Libraries
Parent publication
Title: Science of Synthesis
DOI: 10.1055/b-00000101
Type: Multivolume Edition
Abstract
The nucleophilic addition of enolizable carbonyl compounds to imines and related derivatives such as iminium salts, nitrones, oximes, and hydrazones provides direct access to β-amino carbonyl derivatives. This reactivity has been employed in efficient approaches to the synthesis of enantiomerically pure compounds.
Key words
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