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Hamostaseologie 2017; 37(03): 219-222
DOI: 10.5482/HAMO-16-09-0038
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Schattauer GmbH

Myocardial infarction in a neonate

Lessons for neonatal and internal medicineHerzinfarkt bei einem NeugeborenenLektionen für die Kinderheilkunde und die Innere Medizin
Werner Streif
1   Dept. of Pediatrics I, Medical University of Innsbruck, Innsbruck, Austria
1   Dept. of Pediatrics I, Medical University of Innsbruck, Innsbruck, Austria
› Author Affiliations
Further Information

Publication History

received: 28 September 2016

accepted in revised form: 01 February 2017

Publication Date:
28 December 2017 (online)

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Summary

Due to the lack of evidence-based guidelines, management strategies for neonatal MI should be individualized and administered largely at the discretion of responsible treating teams. Supportive care with a focus on preserving adequate circulation and antithrombotic therapy with a view to restoring vascular patency are the mainstays of treatment. Thrombolytic therapy of neonatal MI includes a chance to completely restore myocardial function. Understanding the resilience of the neonatal heart and mechanism of cardiac cell repair in neonates may spark novel treatment strategies for severe MI in the large number of affected individuals in an aging population.

Zusammenfassung

Für die Behandlung des Herzinfarkts beim Neugeborenen gibt es keine auf Evidenz beruhende Empfehlung. Die Behandlung muss individuell gestaltet werden und obliegt weitestgehend dem jeweiligen Behandlungs- team. Die Behandlung besteht aus supportiven Maßnahmen und antithrombotischen Medikamenten mit dem Ziel der Wiedereröffnung verschlossener Gefäße. Eine Thrombolyse mit Alteplase birgt beim Neugeborenen die Chance einer vollständigen Erholung der Herzfunktion. Das bessere Verständnis der außerordentlichen Widerstandsfähigkeit und Regenerationskraft des Herzes von Neugeborenen kann zur Entwicklung neuer Behandlungsstrategien des Herzinfarkts in einer alternden Gesellschaft beitragen.

Keywords

infant - newborn - myocardial infarction - thrombolytic therapy - tissue plasminogen activator

Schlüsselwörter

Neugeborenes - Kind - Herzinfarkt - Thrombolyse - Alteplase
 

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