Human papillomavirus in head and neck cancer in India: Current status and consensus recommendations

Vedang Murthy; Adnan Calcuttawala; Kirti Chadha; Anil d’Cruz; Arvind Krishnamurthy; Indranil Mallick; Sudhir Nair; Tanuja Teni; Sagar Pawar; Kaustav Talapatra; Asawari Patil; Amit Bhatt; Sanjoy Chatterjee; Monali Swain; Prasad Narayanan; Nikhil Ghadyalpatil; Manish Singhal; Moni Kuriakose; Kumar Prabhash; Jaiprakash Agarwal; Purvish Parikh

doi:10.4103/sajc.sajc_96_17

South Asian Journal of Cancer, Table of Contents

CC BY-NC-ND 4.0 · South Asian J Cancer 2017; 06(03): 093-098
DOI: 10.4103/sajc.sajc_96_17

Review Article

Human papillomavirus in head and neck cancer in India: Current status and consensus recommendations

Vedang Murthy

Department of Radiation Oncology, Tata Memorial Centre, Mumbai, Maharashtra

,

Adnan Calcuttawala

Department of Radiation Oncology, Tata Memorial Centre, Mumbai, Maharashtra

,

Kirti Chadha

Department of Oncopathology, Metropolis Healthcare Ltd., Mumbai, Maharashtra

,

Anil d’Cruz

Department of Head and Neck Surgery, Tata Memorial Centre, Mumbai, Maharashtra

,

Arvind Krishnamurthy

Department of Surgical Oncology, Cancer Institute (WIA), Chennai, Tamil Nadu

,

Indranil Mallick

Department of Radiation Oncology, Tata Medical Centre, Kolkata, West Bengal

,

Sudhir Nair

Department of Head and Neck Surgery, Tata Memorial Centre, Mumbai, Maharashtra

,

Tanuja Teni

Teni Lab, Advanced Centre for Treatment, Research and Education in Cancer, Mumbai, Maharashtra

,

Sagar Pawar

Teni Lab, Advanced Centre for Treatment, Research and Education in Cancer, Mumbai, Maharashtra

,

Kaustav Talapatra

Department of Radiation Oncology, KDAH, Mumbai, Maharashtra

,

Asawari Patil

Department of Pathology, Tata Memorial Centre, Mumbai, Maharashtra

,

Amit Bhatt

Department of Medical Oncology, Avinash Cancer Clinic, Pune, Maharashtra

,

Sanjoy Chatterjee

Department of Radiation Oncology, Tata Medical Centre, Kolkata, West Bengal

,

Monali Swain

Department of Radiation Oncology, Tata Memorial Centre, Mumbai, Maharashtra

,

Prasad Narayanan

Department of Medical Oncology, Cytecare Cancer Hospital, Bengaluru, Karnataka

,

Nikhil Ghadyalpatil

Department of Medical Oncology, Yashoda Cancer Institute, Somajiguda, Hyderabad, Telangana

,

Manish Singhal

Department of Medical Oncology, Indraprastha Apollo Hospitals, New Delhi

,

Moni Kuriakose

Department of Surgical Oncology, Mazumdar-Shaw Cancer Center, Bengaluru, Karnataka

,

Kumar Prabhash

Department of Medical Oncology, Tata Memorial Centre, Mumbai, Maharashtra

,

Jaiprakash Agarwal

Department of Radiation Oncology, Tata Memorial Centre, Mumbai, Maharashtra

,

Purvish Parikh

Department of Medical Oncology, Asian Institute of Oncology, Mumbai, Maharashtra

› Author Affiliations

Abstract

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Abstract

Human papillomavirus (HPV) associated head and neck squamous cell cancers (HNSCC) have become increasingly common in the West, but the same cannot be said about India. These cancers have a different biology and confer a better prognosis, however, its current role in the management of patients in India is not clearly defined. At the 35^th Indian Cooperative Oncology Network conference held in September 2016, a panel of radiation, surgical and medical oncologists, pathologists, and basic scientists from across the country having experience in clinical research with respect to HPV in HNSCC reviewed the available literature from India. All the ideas and facts were thereafter collated in this report. Various topics of controversy in dealing with the diagnosis and management of HPV-associated HNSCC have been highlighted in this report in context to the Indian scenario. Furthermore, the prevalence of the same and its association with tobacco and high-risk sexual behavior has been touched on. Conclusively, a set of recommendations has been proposed by the panel to guide the practicing oncologists of the country while dealing with HPV-associated HNSCC.

Key words

Consensus recommendations - head and neck squamous cell cancers - human papillomavirus - India

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References

References
1 Chaturvedi AK, Engels EA, Pfeiffer RM, Hernandez BY, Xiao W, Kim E, et al. Human papillomavirus and rising oropharyngeal cancer incidence in the United States. J Clin Oncol 2011;29:4294-301.
2 Sturgis EM, Cinciripini PM. Trends in head and neck cancer incidence in relation to smoking prevalence: An emerging epidemic of human papillomavirus-associated cancers? Cancer 2007;110:1429-35.
3 Datta S, Chaturvedi P, Mishra A, Pawar P. A review of Indian literature for association of smokeless tobacco with malignant and premalignant diseases of head and neck region. Indian J Cancer 2014;51:200-8.
4 International Institute for Population Sciences. Ministry of Health and Family Welfare. Government of India, Global Adult Tobacco Survey India 2009-2010; 2010.
5 Centers for Disease Control and Prevention (CDC). Cigarette smoking among adults – United States, 2006. MMWR Morb Mortal Wkly Rep 2007;56:1157-61.
6 Marur S, D'Souza G, Westra WH, Forastiere AA. HPV-associated head and neck cancer: A virus-related cancer epidemic. Lancet Oncol 2010;11:781-9.
7 Singh V, Husain N, Akhtar N, Kumar V, Tewari S, Mishra S, et al. Do human papilloma viruses play any role in oral squamous cell carcinoma in North Indians? Asian Pac J Cancer Prev 2015;16:7077-84.
8 Jitani AK, Raphael V, Mishra J, Shunyu NB, Khonglah Y, Medhi J. Analysis of human papilloma virus 16/18 DNA and its correlation with p16 expression in oral cavity squamous cell carcinoma in North-Eastern India: A chromogenic in-situ hybridization based study. J Clin Diagn Res 2015;9:EC04-7.
9 Sannigrahi MK, Singh V, Sharma R, Panda NK, Radotra BD, Khullar M. Detection of active human papilloma virus-16 in head and neck cancers of Asian North Indian patients. Oral Dis 2016;22:62-8.
10 Kumar R, Rai AK, Das D, Das R, Kumar RS, Sarma A, et al. Alcohol and tobacco increases risk of high risk HPV infection in head and neck cancer patients: Study from North-East Region of India. PLoS One 2015;10:e0140700.
11 Bahl A, Kumar P, Dar L, Mohanti BK, Sharma A, Thakar A, et al. Prevalence and trends of human papillomavirus in oropharyngeal cancer in a predominantly North Indian population. Head Neck 2014;36:505-10.
12 Murthy V, Swain M, Teni T, Pawar S, Kalkar P, Patil A, et al. Human papillomavirus/p16 positive head and neck cancer in India: Prevalence, clinical impact, and influence of tobacco use. Indian J Cancer 2016;53:387-93.
13 Mishra S, Joseph RA, Gupta PC, Pezzack B, Ram F, Sinha DN, et al. Trends in bidi and cigarette smoking in India from 1998 to 2015, by age, gender and education. BMJ Glob Health 2016;1:e000005.
14 Shridhar K, Rajaraman P, Koyande S, Parikh PM, Chaturvedi P, Dhillon PK, et al. Trends in mouth cancer incidence in Mumbai, India (1995-2009): An age-period-cohort analysis. Cancer Epidemiol 2016;42:66-71.
15 Elango JK, Gangadharan P, Sumithra S, Kuriakose MA. Trends of head and neck cancers in urban and rural India. Asian Pac J Cancer Prev 2006;7:108-12.
16 Kulkarni SS, Kulkarni SS, Vastrad PP, Kulkarni BB, Markande AR, Kadakol GS, et al. Prevalence and distribution of high risk human papillomavirus (HPV) Types 16 and 18 in Carcinoma of cervix, saliva of patients with oral squamous cell carcinoma and in the general population in Karnataka, India. Asian Pac J Cancer Prev 2011;12:645-8.
17 Pattanshetty S, Kotrashetti VS, Nayak R, Bhat K, Somannavar P, Babji D. PCR based detection of HPV 16 and 18 genotypes in normal oral mucosa of tobacco users and non-users. Biotech Histochem 2014;89:433-9.
18 Dodson TB. The frequency of human papilloma virus (HPV) is higher in premalignant and malignant oral mucosal lesions than normal mucosa. J Evid Based Dent Pract 2010;10:174-5.
19 Migaldi M, Pecorari M, Forbicini G, Nanni N, Grottola A, Grandi T, et al. Low prevalence of human papillomavirus infection in the healthy oral mucosa of a Northern Italian population. J Oral Pathol Med 2012;41:16-20.
20 Kristoffersen AK, Enersen M, Kverndokk E, Sunde PT, Landin M, Solheim T, et al. Human papillomavirus subtypes in oral lesions compared to healthy oral mucosa. J Clin Virol 2012;53:364-6.
21 González-Losa Mdel R, Manzano-Cabrera L, Rueda-Gordillo F, Hernández-Solís SE, Puerto-Solís L. Low prevalence of high risk human papillomavirus in normal oral mucosa by hybrid capture 2. Braz J Microbiol 2008;39:32-4.
22 Gillison ML, Broutian T, Pickard RK, Tong ZY, Xiao W, Kahle L, et al. Prevalence of oral HPV infection in the United States, 2009-2010. JAMA 2012;307:693-703.
23 Farsi NJ, El-Zein M, Gaied H, Lee YC, Hashibe M, Nicolau B, et al. Sexual behaviours and head and neck cancer: A systematic review and meta-analysis. Cancer Epidemiol 2015;39:1036-46.
24 Nagpal JK, Patnaik S, Das BR. Prevalence of high-risk human papilloma virus types and its association with P53 codon 72 polymorphism in tobacco addicted oral squamous cell carcinoma (OSCC) patients of Eastern India. Int J Cancer 2002;97:649-53.
25 Elango KJ, Suresh A, Erode EM, Subhadradevi L, Ravindran HK, Iyer SK, et al. Role of human papilloma virus in oral tongue squamous cell carcinoma. Asian Pac J Cancer Prev 2011;12:889-96.
26 D'Costa J, Saranath D, Dedhia P, Sanghvi V, Mehta AR. Detection of HPV-16 genome in human oral cancers and potentially malignant lesions from India. Oral Oncol 1998;34:413-20.
27 Gheit T, Vaccarella S, Schmitt M, Pawlita M, Franceschi S, Sankaranarayanan R, et al. Prevalence of human papillomavirus types in cervical and oral cancers in central India. Vaccine 2009;27:636-9.
28 Koppikar P, deVilliers EM, Mulherkar R. Identification of human papillomaviruses in tumors of the oral cavity in an Indian community. Int J Cancer 2005;113:946-50.
29 Ramshankar V, Soundara VT, Shyamsundar V, Ramani P, Krishnamurthy A. Risk stratification of early stage oral tongue cancers based on HPV status and p16 immunoexpression. Asian Pac J Cancer Prev 2014;15:8351-9.
30 Kumaraswamy KL, Vidhya M. Human papilloma virus and oral infections: An update. J Cancer Res Ther 2011;7:120-7.
31 Hammarstedt L, Lindquist D, Dahlstrand H, Romanitan M, Dahlgren LO, Joneberg J, et al. Human papillomavirus as a risk factor for the increase in incidence of tonsillar cancer. Int J Cancer 2006;119:2620-3.
32 D'Souza G, Kreimer AR, Viscidi R, Pawlita M, Fakhry C, Koch WM, et al. Case-control study of human papillomavirus and oropharyngeal cancer. N Engl J Med 2007;356:1944-56.
33 Hafkamp HC, Manni JJ, Haesevoets A, Voogd AC, Schepers M, Bot FJ, et al. Marked differences in survival rate between smokers and nonsmokers with HPV 16-associated tonsillar carcinomas. Int J Cancer 2008;122:2656-64.
34 Reimers N, Kasper HU, Weissenborn SJ, Stützer H, Preuss SF, Hoffmann TK, et al. Combined analysis of HPV-DNA, p16 and EGFR expression to predict prognosis in oropharyngeal cancer. Int J Cancer 2007;120:1731-8.
35 Mehanna H, Beech T, Nicholson T, El-Hariry I, McConkey C, Paleri V, et al. Prevalence of human papillomavirus in oropharyngeal and nonoropharyngeal head and neck cancer – Systematic review and meta-analysis of trends by time and region. Head Neck 2013;35:747-55.
36 Halec G, Holzinger D, Schmitt M, Flechtenmacher C, Dyckhoff G, Lloveras B, et al. Biological evidence for a causal role of HPV16 in a small fraction of laryngeal squamous cell carcinoma. Br J Cancer 2013;109:172-83.
37 Young RJ, Urban D, Angel C, Corry J, Lyons B, Vallance N, et al. Frequency and prognostic significance of p16(INK4A) protein overexpression and transcriptionally active human papillomavirus infection in laryngeal squamous cell carcinoma. Br J Cancer 2015;112:1098-104.
38 Wang H, Zhang Z, Sun R, Lin H, Gong L, Fang M, et al. HPV infection and anemia status stratify the survival of early t2 laryngeal squamous cell carcinoma. J Voice 2015;29:356-62.
39 Rodrigo JP, Hermsen MA, Fresno MF, Brakenhoff RH, García-Velasco F, Snijders PJ, et al. Prevalence of human papillomavirus in laryngeal and hypopharyngeal squamous cell carcinomas in northern Spain. Cancer Epidemiol 2015;39:37-41.
40 Shaughnessy JN, Farghaly H, Wilson L, Redman R, Potts K, Bumpous J, et al. HPV: A factor in organ preservation for locally advanced larynx and hypopharynx cancer? Am J Otolaryngol 2014;35:19-24.
41 Cohen MA, Basha SR, Reichenbach DK, Robertson E, Sewell DA. Increased viral load correlates with improved survival in HPV-16-associated tonsil carcinoma patients. Acta Otolaryngol 2008;128:583-9.
42 Smeets SJ, Hesselink AT, Speel EJ, Haesevoets A, Snijders PJ, Pawlita M, et al. A novel algorithm for reliable detection of human papillomavirus in paraffin embedded head and neck cancer specimen. Int J Cancer 2007;121:2465-72.
43 Badaracco G, Venuti A, Morello R, Muller A, Marcante ML. Human papillomavirus in head and neck carcinomas: Prevalence, physical status and relationship with clinical/pathological parameters. Anticancer Res 2000;20:1301-5.
44 Klussmann JP, Gültekin E, Weissenborn SJ, Wieland U, Dries V, Dienes HP, et al. Expression of p16 protein identifies a distinct entity of tonsillar carcinomas associated with human papillomavirus. Am J Pathol 2003;162:747-53.
45 Ragin CC, Taioli E, Weissfeld JL, White JS, Rossie KM, Modugno F, et al. 11q13 amplification status and human papillomavirus in relation to p16 expression defines two distinct etiologies of head and neck tumours. Br J Cancer 2006;95:1432-8.
46 Robinson M, Schache A, Sloan P, Thavaraj S. HPV specific testing: A requirement for oropharyngeal squamous cell carcinoma patients. Head Neck Pathol 2012;6 Suppl 1:S83-90.
47 Westra WH. Detection of human papillomavirus (HPV) in clinical samples: Evolving methods and strategies for the accurate determination of HPV status of head and neck carcinomas. Oral Oncol 2014;50:771-9.
48 Lewis JS Jr. p16 Immunohistochemistry as a standalone test for risk stratification in oropharyngeal squamous cell carcinoma. Head Neck Pathol 2012;6 Suppl 1:S75-82.
49 Lewis JS Jr., Thorstad WL, Chernock RD, Haughey BH, Yip JH, Zhang Q, et al. p16 positive oropharyngeal squamous cell carcinoma: an entity with a favorable prognosis regardless of tumor HPV status. Am J Surg Pathol 2010;34:1088-96.
50 Fischer CA, Zlobec I, Green E, Probst S, Storck C, Lugli A, et al. Is the improved prognosis of p16 positive oropharyngeal squamous cell carcinoma dependent of the treatment modality? Int J Cancer 2010;126:1256-62.
51 Lassen P, Eriksen JG, Hamilton-Dutoit S, Tramm T, Alsner J, Overgaard J. Effect of HPV-associated p16INK4A expression on response to radiotherapy and survival in squamous cell carcinoma of the head and neck. J Clin Oncol 2009;27:1992-8.
52 Bishop JA, Ma XJ, Wang H, Luo Y, Illei PB, Begum S, et al. Detection of transcriptionally active high-risk HPV in patients with head and neck squamous cell carcinoma as visualized by a novel E6/E7 mRNA in situ hybridization method. Am J Surg Pathol 2012;36:1874-82.
53 Singhi AD, Westra WH. Comparison of human papillomavirus in situ hybridization and p16 immunohistochemistry in the detection of human papillomavirus-associated head and neck cancer based on a prospective clinical experience. Cancer 2010;116:2166-73.
54 Jordan RC, Lingen MW, Perez-Ordonez B, He X, Pickard R, Koluder M, et al. Validation of methods for oropharyngeal cancer HPV status determination in US cooperative group trials. Am J Surg Pathol 2012;36:945-54.
55 Grønhøj Larsen C, Gyldenløve M, Jensen DH, Therkildsen MH, Kiss K, Norrild B, et al. Correlation between human papillomavirus and p16 overexpression in oropharyngeal tumours: A systematic review. Br J Cancer 2014;110:1587-94.
56 Chen ZW, Weinreb I, Kamel-Reid S, Perez-Ordoñez B. Equivocal p16 immunostaining in squamous cell carcinoma of the head and neck: Staining patterns are suggestive of HPV status. Head Neck Pathol 2012;6:422-9.
57 ChuteDJ, Aramouni GT, Brainard JA, Hoschar AP, Kroeger A, Yen-Lieberman B. Hybrid capture 2 human papilloma virus testing for head and neck cytology specimens. J Am Soc Cytopathol 2014;3:173-82.
58 Thavaraj S, Stokes A, Guerra E, Bible J, Halligan E, Long A, et al. Evaluation of human papillomavirus testing for squamous cell carcinoma of the tonsil in clinical practice. J Clin Pathol 2011;64:308-12.
59 Evans MF, Matthews A, Kandil D, Adamson CS, Trotman WE, Cooper K. Discrimination of 'driver' and 'passenger' HPV in tonsillar carcinomas by the polymerase chain reaction, chromogenic in situ hybridization, and p16(INK4a) immunohistochemistry. Head Neck Pathol 2011;5:344-8.
60 Kuo KT, Hsiao CH, Lin CH, Kuo LT, Huang SH, Lin MC. The biomarkers of human papillomavirus infection in tonsillar squamous cell carcinoma-molecular basis and predicting favorable outcome. Mod Pathol 2008;21:376-86.
61 Wittekindt C, Gültekin E, Weissenborn SJ, Dienes HP, Pfister HJ, Klussmann JP. Expression of p16 protein is associated with human papillomavirus status in tonsillar carcinomas and has implications on survival. Adv Otorhinolaryngol 2005;62:72-80.
62 Kulkarni V, Saranath D. Concurrent hypermethylation of multiple regulatory genes in chewing tobacco associated oral squamous cell carcinomas and adjacent normal tissues. Oral Oncol 2004;40:145-53.
63 O'Sullivan B, Huang SH, Su J, Garden AS, Sturgis EM, Dahlstrom K, et al. Development and validation of a staging system for HPV-related oropharyngeal cancer by the International Collaboration on Oropharyngeal cancer Network for Staging: A multicentre cohort study. Lancet Oncol 2016;17:440-51.
64 Rettig E, Kiess AP, Fakhry C. The role of sexual behavior in head and neck cancer: Implications for prevention and therapy. Expert Rev Anticancer Ther 2015;15:35-49.
65 Westra WH. The morphologic profile of HPV-related head and neck squamous carcinoma: Implications for diagnosis, prognosis, and clinical management. Head Neck Pathol 2012;6 Suppl 1:S48-54.
66 Thariat J, Badoual C, Faure C, Butori C, Marcy PY, Righini CA. Basaloid squamous cell carcinoma of the head and neck: Role of HPV and implication in treatment and prognosis. J Clin Pathol 2010;63:857-66.
67 Chernock RD. Morphologic features of conventional squamous cell carcinoma of the oropharynx: 'keratinizing' and 'nonkeratinizing' histologic types as the basis for a consistent classification system. Head Neck Pathol 2012;6 Suppl 1:S41-7.
68 Ragin CC, Taioli E. Survival of squamous cell carcinoma of the head and neck in relation to human papillomavirus infection: Review and meta-analysis. Int J Cancer 2007;121:1813-20.
69 Fakhry C, Westra WH, Li S, Cmelak A, Ridge JA, Pinto H, et al. Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial. J Natl Cancer Inst 2008;100:261-9.
70 Ang KK, Harris J, Wheeler R, Weber R, Rosenthal DI, Nguyen-Tân PF, et al. Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med 2010;363:24-35.