Practical consensus recommendations on management of HR + ve early breast cancer with specific reference to genomic profiling

A. Aggarwal; A. Vaid; A. Ramesh; Purvish M. Parikh; S. Purohit; B. Avasthi; S. Gupta; S. Ranjan; V. Kaushal; S. Salim; R. Singh; S. Minhas; D. Doval

doi:10.4103/sajc.sajc_110_18

South Asian Journal of Cancer, Table of Contents

CC BY-NC-ND 4.0 · South Asian J Cancer 2018; 07(02): 096-101
DOI: 10.4103/sajc.sajc_110_18

Original Article

Practical consensus recommendations on management of HR + ve early breast cancer with specific reference to genomic profiling

A. Aggarwal

Department of Medical Oncology, Sir Ganga Ram Hospital, New Delhi

,

A. Vaid

Department of Medical Oncology, Medanata Hospital, Gurugram, Haryana

,

A. Ramesh

Department of Medical Oncology, HCG Cancer Center, Chennai, Tamil Nadu

Department of Medical Oncology, SMH Curie Cancer Center, New Delhi

,

Purvish M. Parikh

Department of Oncology, Shalby Cancer and Research Institute, Mumbai, Maharashtra

,

S. Purohit

Department of Medical Oncology, Artemis Hospital, Gurugram, Haryana

,

B. Avasthi

Department or Radiation Oncology, Fortis Hospital, New Delhi

,

S. Gupta

Department of Medical Oncology, Sarvodaya Hospital, Faridabad, Haryana

,

S. Ranjan

Department of Medicine, INHS Sanjivani, Kochi, Kerala

,

V. Kaushal

Department of Radiation Oncology, RCC, Rohtak, Haryana

,

S. Salim

Department of Oncology, Hakim Sanaullah Cancer Center, Baramulla, Jammu and Kashmir

,

R. Singh

Department of Medical Oncology, Army Hospital R and R, New Delhi

,

S. Minhas

Department of Medical Oncology, Medanata Hospital, Gurugram, Haryana

,

D. Doval

Department of Medical Oncology, Rajiv Gandhi Cancer Institute, New Delhi

› Author Affiliations

Abstract

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Abstract

Breast cancer is a heterogeneous disease and patients are managed clinically based on ER, PR, HER2 expression, and key risk factors. The use of gene expression assays for early stage disease is already common practice. These tests have found a place in risk stratifying the heterogeneous group of stage I–II breast cancers for recurrence, for predicting chemotherapy response, and for predicting breast cancer-related mortality. Most guidelines for hormone receptor (HR)–positive early breast cancer recommend addition of adjuvant chemotherapy for most women, leading to overtreatment, which causes considerable morbidity and cost. Expert oncologist discussed about strategies of gene expression assays and aid in chemotherapy recommendations for treatment of HR + ve EBC and the expert group used data from published literature, practical experience and opinion of a large group of academic oncologists to arrive at this practical consensus recommendations for the benefit of community oncologists.

Key words

ki67 - mammaprint - oncotype dx - predictive test - prosigna - taxane

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References

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