ABSTRACT
Objectives: The hybrid layer at the interface of resin-modified glass ionomer cements and dentin
is prone to degradation by endogenous matrix metalloproteinases. We aimed to investigate
the effect of two types of collagen crosslinkers, carbodiimide and proanthocyanidin
(PA), on immediate and medium-term bond strength of a resin-modified glass ionomer
to dentin. Materials and Methods: Seventy-two molars were flattened on the occlusal surface to expose dentin. The specimens
were divided into control, 1-ethyl-3-(3-dimethylaminopropy) carbodiimide hydrochloride
(EDC), and PA groups (n = 24). In the EDC and PA groups, carbodiimide and PA solutions were applied for 1
min, respectively. Resin-modified glass ionomer was bonded. Half of the specimens
in each group were tested for shear bond strength after 24 h and the other half were
tested after 6 months. Statistical Analysis: Data were analyzed with SPSS version 16 (SPSS Inc, Chicago, IL, USA), using two-way
ANOVA, and subgroup analysis was performed using one-way ANOVA, Tukey's test, and
t-test. Results: Two-way ANOVA showed that treatment and time affected the bond strength. Carbodiimide
and PA did not affect the immediate bond strength (P = 0.51). After 6 months, the bond strength of the EDC group was significantly lower
than that of the control and PA groups. Bond strength of the control and PA groups
increased after 6 months (P ≤ 0.002). Conclusion: PA did not interfere with maturation of RMGIC unlike carbodiimide. Therefore, it
can be suggested as an matrix metalloproteinase inhibitor before bonding of resin-modified
glass ionomer to dentin.
Key words:
Bond strength - carbodiimide - matrix metalloproteinase - proanthocyanidin - resin-modified
glass ionomer