Histopathological profile of brain tumors: A 12-year retrospective study from Madinah, Saudi Arabia

Albasri Mohammed; Almuhamdi Hamdan; Alqaidi Homoud

doi:10.4103/ajns.AJNS_185_19

Asian Journal of Neurosurgery, Table of Contents

CC BY-NC-ND 4.0 · Asian J Neurosurg 2019; 14(04): 1106-1111
DOI: 10.4103/ajns.AJNS_185_19

Original Article

Histopathological profile of brain tumors: A 12-year retrospective study from Madinah, Saudi Arabia

Authors

Albasri Mohammed

⁰Department of Pathology, Taibah University, Al-Madinah
Almuhamdi Hamdan

⁰Department of Pathology, Taibah University, Al-Madinah
Alqaidi Homoud

¹Department of Surgery, Faculty of Medicine, Taibah University, Al-Madinah

Abstract

Objectives: The objective of this study is to characterize the histopathological types and basic demographic parameters of brain tumors in the Madinah region of Saudi Arabia and to analyze and compare the findings with previously published literature. Materials and Methods: This retrospective study was conducted in the Department of Pathology, King Fahad Hospital, Madinah, Saudi Arabia, and comprised cases of brain tumors during 12 years (from January 2006 to December 2017). Basic demographic data, tumor site, and histopathological patterns were obtained from the medical records and further analyzed and graded according to the World Health Organization (WHO) 2007 classification. Results: A total of 227 brain tumors in 122 (53.7%) males and 105 (46.3%) female patients were recorded. Pediatric and adult patients accounted for 10.6% and 89.4% of the cases, respectively. The predominant age group affected was between 40 and 49 years (23.5%). The most common histopathological diagnosis in the present study was meningioma (30.8%), followed by astrocytic tumors (29.1%), metastatic tumors (7.7%), and embryonal tumors (6.6%). The meningothelial meningioma was the most common type of meningioma (48.5%). The majority of astrocytic tumors (52%) fell under the WHO Grade IV. Conclusion: This retrospective study established a baseline profile of brain tumors based primarily on the histopathological experience at a tertiary care hospital in the Madinah, Saudi Arabia, and provides an initiating platform to workup for future population targeted studies on brain tumors.

Key-words:

Brain tumors - histopathology - Madinah - World Health Organization 2007

Full Text

References

References
1 Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, et al. The 2016 World Health Organization classification of tumors of the central nervous system: A summary. Acta Neuropathol 2016;131:803-20.
2 McGuire S. World cancer report 2014. Geneva, Switzerland: World Health Organization, International Agency for Research on Cancer, WHO Press, 2015. Adv Nutr 2016;7:418-9.
3 Ostrom QT, Gittleman H, Fulop J, Liu M, Blanda R, Kromer C, et al. CBTRUS statistical report: Primary brain and central nervous system tumors diagnosed in the United States in 2008-2012. Neuro Oncol 2015;17 Suppl 4:iv1-62.
4 Bauchet L, Rigau V, Mathieu-Daudé H, Figarella-Branger D, Hugues D, Palusseau L, et al. French brain tumor data bank: Methodology and first results on 10,000 cases. J Neurooncol 2007;84:189-99.
5 Ostrom QT, Gittleman H, Liao P, Rouse C, Chen Y, Dowling J, et al. CBTRUS statistical report: Primary brain and central nervous system tumors diagnosed in the United States in 2007-2011. Neuro Oncol 2014;16 Suppl 4:iv1-63.
6 Kaneko S, Nomura K, Yoshimura T, Yamaguchi N. Trend of brain tumor incidence by histological subtypes in Japan: Estimation from the brain tumor registry of Japan, 1973-1993. J Neurooncol 2002;60:61-9.
7 Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, et al. The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 2007;114:97-109.
8 Arora RS, Alston RD, Eden TO, Estlin EJ, Moran A, Birch JM. Age-incidence patterns of primary CNS tumors in children, adolescents, and adults in England. Neuro Oncol 2009;11:403-13.
9 Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, et al. GLOBOCAN 2012, Cancer Incidence and Mortality Worldwide. Vol. 11. Lyon, France: International Agency for Research on Cancer; 2013. Available from: http://globocan.iarc.fr. [Last accessed on 2019 Feb 22].
10 Annual Cancer Incidence Report for Saudi Cancer Registry (SCR). Available from: https://nhic.gov.sa/eServices/Documents/2014.pdf. [Last updated on 2017 Sep 09; Last accessed on 2018 Dec 02].
11 Taha MS, Almsned FM, Hassen MA, Atean IM, Alwbari AM, Alharbi QK, et al. Demographic and histopathological patterns of neuro-epithelial brain tumors in Eastern province of Saudi Arabia. Neurosciences (Riyadh) 2018;23:18-22.
12 Ostrom QT, Gittleman H, Xu J, Kromer C, Wolinsky Y, Kruchko C, et al. CBTRUS statistical report: Primary brain and other central nervous system tumors diagnosed in the United States in 2009-2013. Neuro Oncol 2016;18:v1-v75.
13 Parkin DM. Global cancer statistics in the year 2000. Lancet Oncol 2001;2:533-43.
14 Jazayeri SB, Rahimi-Movaghar V, Shokraneh F, Saadat S, Ramezani R. Epidemiology of primary CNS tumors in Iran: A systematic review. Asian Pac J Cancer Prev 2013;14:3979-85.
15 Yeole BB. Trends in the brain cancer incidence in India. Asian Pac J Cancer Prev 2008;9:267-70.
16 Ghanghoria S, Mehar R, Kulkarni CV, Mittal M, Yadav A, Patidar H. Retrospective histological analysis of CNS tumors – A 5 year study. Int J Med Sci Public Health 2014;3:1205-7.
17 Masoodi T, Gupta RK, Singh JP, Khajuria A. Pattern of central nervous system neoplasm: A study of 106 cases. JK Pract 2012;17:42-46.
18 Das A, Chapman CA, Yap WM. Histological subtypes of symptomatic central nervous system tumours in Singapore. J Neurol Neurosurg Psychiatry 2000;68:372-4.
19 Idowu O, Akang EE, Malomo A. Symptomatic primary intracranial neoplasms in Nigeria, West Africa. J Neurol Sci (Turkish) 2007;24:212-18.
20 Dho YS, Jung KW, Ha J, Seo Y, Park CK, Won YJ, et al. An updated nationwide epidemiology of primary brain tumors in republic of Korea, 2013. Brain Tumor Res Treat 2017;5:16-23.
21 Nakamura H, Makino K, Yano S, Kuratsu J. Kumamoto Brain Tumor Research Group. Epidemiological study of primary intracranial tumors: A regional survey in Kumamoto prefecture in Southern Japan–20-year study. Int J Clin Oncol 2011;16:314-21.
22 Dobec-Meić B, Pikija S, Cvetko D, Trkulja V, Pazanin L, Kudelić N, et al. Intracranial tumors in adult population of the Varazdin county (Croatia) 1996-2004: A population-based retrospective incidence study. J Neurooncol 2006;78:303-10.
23 Lona C, Tabiadon G, Currò Dossi B, Mohsenipour I. Incidence of primary intracranial tumors in the province of Bolzano 1980-84. Ital J Neurol Sci 1988;9:237-41.
24 Campos S, Davey P, Hird A, Pressnail B, Bilbao J, Aviv RI, et al. Brain metastasis from an unknown primary, or primary brain tumour? A diagnostic dilemma. Curr Oncol 2009;16:62-6.
25 Bangash MH. Incidence of brain tumours at an academic centre in Western Saudi Arabia. East Afr Med J 2012;88:138-42.
26 Aryal G. Histopathological pattern of central nervous system tumor: A three year retrospective study. J Pathol Nepal 2011;1:22-5.
27 Suh YL, Koo H, Kim TS, Chi JG, Park SH, Khang SK, et al. Tumors of the central nervous system in Korea: A multicenter study of 3221 cases. J Neurooncol 2002;56:251-9.
28 Chen L, Zou X, Wang Y, Mao Y, Zhou L. Central nervous system tumors: A single center pathology review of 34,140 cases over 60 years. BMC Clin Pathol 2013;13:14.
29 Walker EV, Davis FG. CBTR founding affiliates. Malignant primary brain and other central nervous system tumors diagnosed in Canada from 2009 to 2013. Neuro Oncol 2019;21:360-9.