Interleukin-1 receptor antagonist levels in gingival crevicular fluid and serum in nonsmoking women with preterm low birth weight and intrauterine growth retardation

Nezahat Arzu Kayar; Nilgun Ozlem Alptekin; Seyfullah Haliloglu

doi:10.4103/1305-7456.149655

European Journal of Dentistry, Table of Contents

CC BY-NC-ND 4.0 · Eur J Dent 2015; 09(01): 109-116
DOI: 10.4103/1305-7456.149655

Original Article

Dental Investigation Society

Interleukin-1 receptor antagonist levels in gingival crevicular fluid and serum in nonsmoking women with preterm low birth weight and intrauterine growth retardation

Nezahat Arzu Kayar

¹Department of Periodontology, Oral and Dental Health Center, The Ministry Health of Turkey, Antalya, Turkiye

,

Nilgun Ozlem Alptekin

²Department of Periodontology, Faculty of Dentistry, Baskent University, Ankara, Turkiye

,

Seyfullah Haliloglu

³Department of Biochemistry, Faculty of Veterinary, Selcuk University, Konya, Turkiye

› Author Affiliations

Abstract

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ABSTRACT

Objective: The aim of this study was to evaluate interleukin (IL)-1 β and IL-1 receptor antagonist (IL-1ra) levels in gingival crevicular fluid (GCF) and serum (S) in nonsmoking women with normal birth (NB), preterm low birth weight (PLBW), and intra-uterine growth retardation (IUGR). Materials and Methods: In this unmatched case-control study design, 64 women with NB, 45 women with PLBW, and 47 women with IUGR were recruited within 24 h delivery. Clinical periodontal parameters were recorded. IL-1 β and IL-1ra levels in GCF (pg/30 s) and serum (pg/ml) of were evaluated using commercial enzyme immunoassay and ELISA kits. Results: Greater pocket depth and clinical attachment loss were observed in PLBW and IUGR women than in NB women (P < 0.05). The total amounts of IL-1ra and IL-β of GCF were higher levels in NB women than PLBW and IUGR women (P < 0.05). The lowest total amount of IL-1ra of GCF was found in IUGR women (P < 0.05). The concentrations of IL-1ra in serum samples were not statistically significant for any of the study groups (P > 0.05). Conclusion: It can be suggested that worse periodontal conditions and the low levels of IL-1ra in GCF may be an important factor in adverse pregnancy outcomes.

Key words:

Cytokine(s) - gingival crevicular fluid - periodontal-systemic disease interactions - serum

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References

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