Natural killer T cells in lipoprotein metabolism and atherosclerosis

Godfrey S. Getz; Paul A. VanderLaan; Catherine A. Reardon

doi:10.1160/TH11-05-0336

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2011; 106(05): 814-819
DOI: 10.1160/TH11-05-0336

Theme Issue Article

Schattauer GmbH

Natural killer T cells in lipoprotein metabolism and atherosclerosis

Authors

Godfrey S. Getz

¹Department of Molecular Genetics, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, the Netherlands
Paul A. VanderLaan

¹Department of Molecular Genetics, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, the Netherlands
Catherine A. Reardon

¹Department of Molecular Genetics, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, the Netherlands

Abstract

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Summary

Cells of both the innate and adaptive immune system participate in the development of atherosclerosis, a chronic inflammatory disorder of medium and large arteries. Natural killer T (NKT) cells express surface markers characteristic of natural killer cells and conventional T cells and bridge the innate and adaptive immune systems. The development and activation of NKT cells is dependent upon CD1d, a MHC-class I-type molecule that presents lipids, especially glycolipids to the T cell receptors on NKT cells. There are two classes of NKT cells; invariant NKT cells that express a semi-invariant T cell receptor and variant NKT cells. This review summarises studies in murine models in which the effect of the activation, overexpression or deletion of NKT cells or only invariant NKT cells on atherosclerosis has been examined.

Keywords

Atherosclerosis - CD1d - NKT cells

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References

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