The significance of ADAMTS13 in a patient with thrombotic thrombocytopenic purpura complicated autoimmune hepatitis

Michiomi Shimizu; Shosaku Nomura; Kazuyoshi Ishii; Youichi Mohri; Nao Umei; Satoshi Suzuki; Yoshio Matsuo; Ayami Isonishi; Masanori Matsumoto; Fumiaki Urase; Yasuhiro Maeda; Yoshihiro Fujimura

doi:10.1160/TH08-09-0606

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2009; 101(03): 599-600
DOI: 10.1160/TH08-09-0606

Letters to the Editor

Schattauer GmbH

The significance of ADAMTS13 in a patient with thrombotic thrombocytopenic purpura complicated autoimmune hepatitis

Michiomi Shimizu

¹Division of Hematology, Kishiwada City Hospital, Kishiwada, Osaka, Japan

,

Shosaku Nomura

¹Division of Hematology, Kishiwada City Hospital, Kishiwada, Osaka, Japan

,

Kazuyoshi Ishii

¹Division of Hematology, Kishiwada City Hospital, Kishiwada, Osaka, Japan

,

Youichi Mohri

²Division of Gastroenterology and Hepatology, Kishiwada City Hospital

,

Nao Umei

³Division of Emergency and Critical Care Medicine, Kishiwada City Hospital

,

Satoshi Suzuki

³Division of Emergency and Critical Care Medicine, Kishiwada City Hospital

,

Yoshio Matsuo

³Division of Emergency and Critical Care Medicine, Kishiwada City Hospital

,

Ayami Isonishi

⁴Department of Blood Transfusion Medicine, Nara Medical University, Kashihara, Japan

,

Masanori Matsumoto

⁴Department of Blood Transfusion Medicine, Nara Medical University, Kashihara, Japan

,

Fumiaki Urase

⁵Department of Hematology, Kinki University, School of Medicine; Higashi-Osaka City, Japan

,

Yasuhiro Maeda

⁵Department of Hematology, Kinki University, School of Medicine; Higashi-Osaka City, Japan

,

Yoshihiro Fujimura

⁴Department of Blood Transfusion Medicine, Nara Medical University, Kashihara, Japan

References
1 Moschowitz E. Hyaline thrombosis of the terminal arterioles and capillaries: a hitherto undescribed disease. Proc NY Pathol Sac 1924; 24: 21-24.
2 Moake JL. Thrombotic microangiopathies. N Engl J Med 2002; 347: 589-600.
3 Hagel S, Jantsch J, Budde U. et al. Treatment of acquired thrombotic thrombocytopenic purpura (TTP) with plasma infusion plus rituximab. Thromb Haemost 2008; 100: 151-153.
4 Zheng X, Chung D, Takayama TK. et al. Structure of von Willebrand factor (vWF) cleaving protease (ADAMTS13), a metalloprotease involved in thrombotic thrombocytopenic purpura. J Biol Chem 2001; 276: 41059-41063.
5 Luken BM, Turenhout EA, Hulstein JJ. et al. The space domain of ADAMTS13 contains a major binding site for antibodies in patients with thrombotic thrombocytopenic purpura. Thromb Haemost 2005; 93: 267-274.
6 Luken BM, Turenhout EA, Kaijen PH. et al. Aminoacid regions 572–579 and 657–666 of the spacer domain of AMATS13 provide a common antigenic core required for binding of antibodies in patients with acquired TTP. Thromb Haemost 2006; 96: 295-301.
7 Donadelli R, Banteria F, Galbusera M. et al. Invitro and in-vivo consequences of mutations in the von Willebrand factor cleaving protease ADAMTS13 in thrombotic thrombocytopenic purpura. Thromb Haemost 2006; 96: 454-464.
8 Hommais A, Rayes J, Houllier A. et al. Molecular characterization of four ADAMTS13 mutations responsible for congenital thrombotic thrombocytopenic purpura (Upshaw-Schulman syndrome). Thromb Haemost 2007; 98: 593-599.
9 Uemura M, Tatsumi K, Matsumoto M. et al. Localization of ADAMTS13 to the stellate cells of human liver. Blood 2005; 106: 922-924.
10 Uemura M, Fujimura Y, Matsumoto M. et al. Comprehensive analysis of ADAMTS13 in patients with liver cirrhosis. Thromb Haemost 2008; 99: 1019-1029.
11 Czaja AJ. Autoimmune hepatitis: evolving concepts and treatment strategies. Deg Dis Sci 1995; 40: 435-438.
12 Alvarez F, Berg PA, Bianch FB. et al. International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis. J Hepatol 1999; 31: 929-938.
13 Shibuya A, Satomichi A, Nagaba S. et al. Thrombotic thrombocytopenic purpura in autoimmune hepatitis. J Gastroenterol 2001; 36: 569-573.