Thrombophilic risk factors and homocysteine levels in Behçet’s disease in eastern Spain and their association with thrombotic events

José M Ricart; Amparo Vayá; José Todolí; Javier Calvo; Piedad Villa; Amparo Estellés; Francisco España; Marisa Santaolaria; Dolores Corella; Justo Aznar

doi:10.1160/TH05-10-0659

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2006; 95(04): 618-624
DOI: 10.1160/TH05-10-0659

Blood Coagulation, Fibrinolysis and Celular Haemostasis

Schattauer GmbH

Thrombophilic risk factors and homocysteine levels in Behçet’s disease in eastern Spain and their association with thrombotic events

Authors

José M Ricart

¹Dermatology Service, La Fe University Hospital, Valencia, Spain, La Fe University Hospital, Valencia, Spain
Amparo Vayá

²Hemorheology and Thrombosis Unit, Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain
José Todolí

³Internal Medicine Service, La Fe University Hospital, Valencia, Spain
Javier Calvo

⁴Rheumatology Service, General University Hospital, Valencia, Spain
Piedad Villa

²Hemorheology and Thrombosis Unit, Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain
Amparo Estellés

⁵Research Center, La Fe University Hospital, Valencia, Spain
Francisco España

⁵Research Center, La Fe University Hospital, Valencia, Spain
Marisa Santaolaria

²Hemorheology and Thrombosis Unit, Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain
Dolores Corella

⁶Department of Preventive Medicine, School of Medicine, University of Valencia, Valencia, Spain
Justo Aznar

²Hemorheology and Thrombosis Unit, Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain

Abstract

Summary

Behçet’s disease (BD) is a chronic inflammatory disorder in which thrombosis occurs in about 30% of patients. The prothrombotic mechanisms are unknown. Thrombophilic defects and hyperhomocysteinaemia may be involved in the pathogenesis of thrombotic events, although results have been controversial. Moreover, no information is available on this issue for eastern Spain.We studied the prevalence of inherited and acquired thrombophilic risk factors in 79 patients with BD (43 men, 36 women) who had (n = 23) or did not have (n = 56) thrombosis, and in 84 healthy control subjects (42 men, 42 women). Risk factors examined were antithrombin, protein C and protein S levels, factor V Leiden, the prothrombin G20210A mutation, the methylenetetrahydrofolate reductase C677T polymorphism, and acquired thrombophilic risk factors, including anticardiolipin antibodies, lupus anticoagulant, and serum homocysteine levels. There were no differences between patients and controls in any of the parameters studied.When we studied BD patients with and without thrombotic events, the only thrombophilic defect that differed was the prothrombin G20210A mutation: Three out of 23 patients with thrombosis were carriers, compared with none of 56 patients without thrombosis (p = 0.022).Two of the three carriers developed catastrophic or recurrent thrombotic episodes; one wasa homozygous carrier of the G20210A prothrombin mutation and the other was doubly heterozygous for the G20210A prothrombin mutation and factor V Leiden. A meta-analysis demonstrated an association of factor V Leiden and prothrombin mutation with thrombosis in BD. When studies from Turkey were excluded from the meta-analysis, only the prothrombin G20210A mutation was associated with thrombosis.

Keywords

Behçet’s disease - hyperhomocysteinaemia - thrombophilic risk factors - thrombosis - meta-analysis

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Referenzen

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