Thrombosis and Haemostasis, Table of Contents Thromb Haemost 2005; 94(06): 1177-1180DOI: 10.1160/TH05-05-0342 Blood Coagulation, Fibrinolysis and Cellular Haemostasis Schattauer GmbH Continuous infusion of recombinant factor VIIa for surgery in patients with deficiency of factor VII Authors Author Affiliations Sam Schulman 1 Coagulation Unit, Department of Haematology and Geir E. Tjønnfjord 3 Section of Haematology, Department of Internal Medicine, Rikshospitalet University Hospital, Oslo, Norway Richard Wallensten 2 Department of Orthopaedic Surgery, Karolinska University Hospital, Stockholm, Sweden Uri Martinowitz 4 The National Hemophilia Center, The Chaim Sheba Medical Center, Tel Hashomer, Israel Gili Kenet 4 The National Hemophilia Center, The Chaim Sheba Medical Center, Tel Hashomer, Israel Recommend Article Abstract Buy Article(opens in new window) Summary The administration of recombinant activated factor VII (rFVIIa) by continuous infusion has provided a safe and convenient alternative to bolus injections in haemophiliacs with inhibitors, but it has only been reported in a single case with congenital factorVII (FVII) deficiency. The results of 12 consecutive surgical procedures in 7 patients with congenital FVII deficiency are reported here. rFVIIa was always given in continuous infusion, aiming at plasma FVII activity of 0.5 IU/mL. Treatment was given for 2 to 7 days with a mean total dose of 7.8 mg rFVIIa. Blood loss was as expected from the different types of procedures and the only thromboembolic complication was a superficial thrombophlebitis at the infusion site. This mode of substitution was therefore safe, effective and well tolerated. Keywords KeywordsFactor VII deficiency - recombinant factor VIIa - surgery - bleeding Full Text References References 1 Hedner U, Glazer S, Pingel K. et al Successful use of recombinant factor VIIa in a patient with severe haemophilia A during synovectomy. Lancet 1988; 2: 1193. 2 Bauer K. Treatment of factor VII deficiency with recombinant factor VIIa. Haemostasis 1996; 26 (Suppl. 01) 155-8. 3 Ingerslev J, Knudsen L, Hvid I. et al Use of recombinant factor VIIa in factor-VII-deficient patients. 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