The story of the serpin plasminogen activator inhibitor 1: is there any need for another mutant?

Bart De Taeye; Ann Gils; Paul J. Declerck

doi:10.1160/TH04-05-0269

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2004; 92(05): 898-924
DOI: 10.1160/TH04-05-0269

Review Article

Schattauer GmbH

The story of the serpin plasminogen activator inhibitor 1: is there any need for another mutant?

Bart De Taeye

¹Laboratory for Pharmaceutical Biology and Phytopharmacology, Faculty of Pharmaceutical Sciences, Katholieke Universiteit Leuven, Belgium

,

Ann Gils

¹Laboratory for Pharmaceutical Biology and Phytopharmacology, Faculty of Pharmaceutical Sciences, Katholieke Universiteit Leuven, Belgium

,

Paul J. Declerck

¹Laboratory for Pharmaceutical Biology and Phytopharmacology, Faculty of Pharmaceutical Sciences, Katholieke Universiteit Leuven, Belgium

› Author Affiliations

Abstract

Summary

The importance of obtaining insight in the structure/function relationship in the serpin plasminogen activator inhibitor type1 can be understood from the major role PAI-1 plays in different (patho)physiological processes, mainly because of its involvement in the plasminogen/plasmin system. Moreover, during the past years, studies indicated a contribution of PAI-1 to the development of cardiovascular disease in common syndromes such as atherosclerosis, diabetes and hypertension. Furthermore, PAI-1 also inhibits u-PA, attributing a role in phenomena such as cell migration and tissue remodelling. Considering the role of PAI-1 in such various pathogenic pathways, detailed insight into the structure/function relationship in PAI-1 might provide a means of interfering with a given pathological situation without disturbing other physiological processes. Therefore, since the discovery of PAI-1 and the cloning of its cDNA 20 years ago, over 600 PAI-1 variants have been constructed, elucidating the most important structural features of PAI-1. This review gives an overview of the contribution of the different PAI-1 variants to the understanding of the structure/function relationship in PAI-1, based on the different functional features of PAI-1.

Keywords

Review - serpin - PAI-1 - mutagenesis - structure/function

Full Text

References

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