Thrombotic complications in patients with hereditary bleeding disorders

Massimo Franchini

doi:10.1160/TH04-03-0148

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2004; 92(02): 298-304
DOI: 10.1160/TH04-03-0148

Review Article

Schattauer GmbH

Thrombotic complications in patients with hereditary bleeding disorders

Massimo Franchini

¹Servizio di Immunoematologia e Trasfusione – Centro Emofilia, Azienda Ospedaliera di Verona,Verona, Italy

› Institutsangaben

Abstract

Summary

Thromboses in patients with hereditary bleeding disorders are uncommon. However, in some cases, the co-existence of prothrombotic risk factors may increase the likelihood of developing thrombotic complications in such patients. This review summarizes the cases of thrombosis reported in the literature and analyzes the most important risk factors for thrombosis in patients with a congenital bleeding tendency. In particular we focus on central venous catheter (CVC)-associated thrombosis, on the thrombotic complications of coagulation factor concentrate therapy and on the presence of prothrom-botic gene mutations. Data were identified by searches of the published literature, including PubMed, references from reviews and abstracts from the most important meetings on this topic. In conclusion, there is increasing evidence that thrombotic complications in patients with hereditary bleeding disorders have a multifactorial pathogenesis, depending on exogenous (coagulation factor replacement therapy, CVC, HIV infection) and/or endogenous (prothrombotic gene mutations) risk factors.

Keywords

Bleeding disorders - hemophilia - thrombosis

Volltext

Referenzen

References
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