New Cytotoxic Diarylheptanoids from the Rhizomes of Alpinia officinarum

Abstract

Bioassay-guided fractionation of the cytotoxic MeOH extract from the rhizomes of Alpinia officinarum Hance led to the isolation of two new diarylheptanoids named alpinoid D (1) and E (2), together with fifteen known diarylheptanoids (3 - 17). The structures of compounds 1 and 2 were elucidated on the basis of spectroscopic data and chemical evidence. The cytotoxic activity of the isolated diarylheptanoids was evaluated against the IMR-32 human neuroblastoma cell line. Among the tested compounds, 11, 12 and 14 exhibited the most potent activities with IC₅₀ values of 0.83, 0.23 and 0.11 μM, respectively.

Alpinia officinarum - Zingiberaceae - diarylheptanoids - cytotoxicity - neuroblastoma cell line

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