The Angiogenic Effect of Tissue Factor on Tumors and Wounds

Katsumi Nakagawa; Youming Zhang; Hajime Tsuji; Masami Yoshizumi; Teruhisa Kasahara; Hiromi Nishimura; Peter P. Nawroth; Masao Nakagawa

doi:10.1055/s-2007-995843

Seminars in Thrombosis and Hemostasis, Inhaltsverzeichnis

Semin Thromb Hemost 1998; 24(3): 207-210
DOI: 10.1055/s-2007-995843

The Angiogenic Effect of Tissue Factor on Tumors and Wounds

Katsumi Nakagawa^* ^† , Youming Zhang^† , Hajime Tsuji^* , Masami Yoshizumi^* , Teruhisa Kasahara^* , Hiromi Nishimura^* , Peter P. Nawroth^† , Masao Nakagawa^†

From the *Second Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto Japan and
†Department of Medicine, University of Heidelberg, Heidelberg, Germany

Abstract

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Abstract

We report a novel function of tissue factor (TF) as an angiogenic factor in malignant and non-malignant cells and tissue. When methylcholanthrene A-induced murine fibrosarcoma (Meth-A sarcoma) was stably transfected with mouse TF (mTF) cDNA (pXT1 expression vector), its vascularization in vivo was significantly enhanced, whereas TF-antisense suppressed the vascularization and tumor growth. In vitro expression of vascular endothelial growth factor (VEGF) was enhanced with stable transfection of mTF (pcDNA3 expression vector) into a mouse fibroblast cell line (NIH3T3). Moreover, in vivo topical transfection of mTF (pcDNA3) showed an enhanced vascularization and healing in a diabetic mouse wound-healing model. This effect of TF as an angiogenic factor might be useful as an antitumor therapy against hypervascular tumors or as a novel agent against delayed wound healing.

Keywords:

Tissue factor (TF) - vascular endothelial growth factor (VEGF) - angiogenesis - tumor - wound healing

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