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Planta Med 1992; 58(6): 533-534
DOI: 10.1055/s-2006-961543
Papers

© Georg Thieme Verlag Stuttgart · New York

Effects of Three Compounds Extracted from Morinda lucida on Plasmodium falciparum

K. Koumaglo1 , M. Gbeassor2 , O. Nikabu1 , C. de Souza3 , W. Werner4
  • 1Département de Chimie, Université du Bénin, BP. 1515, Lomé, Togo
  • 2Département de Physiologie, Faculté des Sciences, Université du Bénin, BP. 1515, Lomé, Togo
  • 3Laboratoire de Biologie Cellulaire et de Génétique, IUT de Santé et des Sciences Biologiques; Université du Bénin, BP. 1515, Lomé, Togo
  • 4Institut für Pharmazeutische Chemie, Westfälische Wilhelms-Universität, Hittorfstr. 58-62, D(W)-4400 Münster, Federal Republic of Germany
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Publikationsverlauf

1991

Publikationsdatum:
05. Januar 2007 (online)

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Abstract

The effects of three compounds, digito-lutein (1), rubiadin 1-methyl ether (2) and damnacanthal (3) extracted from the stem bark and the roots of Morinda lucida Benth. on the growth of Plasmodium falciparum in vitro were investigated. The number of parasites (schizonts) decreased significantly in a dose-dependent manner, and 100% of inhibition was obtained with 30 to 40 μg of each compound tested. The IC50 values were calculated.

Key words

Morinda lucida - Rubiaceae - anthraquinones - Plasmodium falciparum