Anti-Tumor-Promotion by Principles Obtained from Angelica keiskei

T. Okuyama; M. Takata; J. Takayasu; T. Hasegawa; H. Tokuda; A. Nishino; H. Nishino; A. Iwashima

doi:10.1055/s-2006-960082

Planta Medica, Table of Contents

Planta Med 1991; 57(3): 242-246
DOI: 10.1055/s-2006-960082

Papers

Anti-Tumor-Promotion by Principles Obtained from Angelica keiskei

T. Okuyama² , M. Takata² , J. Takayasu³ , T. Hasegawa³ , H. Tokuda³ , A. Nishino³ , H. Nishino³ , A. Iwashima³

²Department of Pharmacognosy and Phytochemistry, Meiji College of Pharmacy, Nozawa 1-35-23, Setagaya-ku, Tokyo 154, Japan
³Department of Biochemistry, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602, Japan

Studies on the anti-tumor-promoting activity of naturally occurring substances, Part V. Part IV of this series: Nishino, H., Okuyama, T., Takata, M, Shibata, S., Tokuda, H., Takayasu, J., Hasegawa, T., Nishino, A., Ueyama, H., Iwashima, A. (1991) Carcinogenesis 11, 1557

Abstract

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Abstract

Potent anti-tumor promoter activity has been found in the nonpolar extracts of the root of “Ashita-Ba”, Angelica keiskei Koidz. (Umbelliferae), which is eaten as a vegetable in Japan. From this active fraction, two angular furanocoumarins, archangelicin (1) and 8(S),9(R)-9-angeloyloxy-8,9-dihydrooroselol (2), three linear furanocoumarins, psoralen (3), bergapten (4) and xanthotoxin (5), and three chalcones, 4-hydroxyderricin (6), xanthoangelol (7) and a novel chalcone named ashitaba-chalcone (8), were isolated. Among these compounds, two angular type furanocoumarins, 1 and 2, and three chalcones, 6-8, suppressed 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated ³²Pi-incorporation into phospholipids of cultured cells, whereas coumarins 3-5 were less effective. In addition, chalcones 6 and 7 were proved to have anti-tumor-promoting activity in mouse skin carcinogenesis induced by 7,12-dimethylbenz[a]anthracene (DMBA) plus TPA. Since chalcones 6 and 7 showed calmodulin-interacting property, both chalcones may reveal anti-tumor-promoting activity via the modulation of calmodulin involved systems. These chalcones may be useful to develop the effective method for cancer prevention.

Key words

Angelica keiskei - anti-tumor promoting activity - angular furanocoumarins - linear furanocoumarins - chalcones - ashitaba-chalcone

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