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Planta Med 1996; 62(6): 573-575
DOI: 10.1055/s-2006-957978
Letters

© Georg Thieme Verlag Stuttgart · New York

Antineoplastic Agents; I. Three Spirostanol Glycosides from Rhizomes of Dioscorea collettii var. hypoglauca

Ke Hu1 , Aijun Dong2 , Xinsheng Yao1 , Hisayoshi Kobayashi3 , Shigeo Iwasaki3
  • 1Department of Phytochemistry, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110015, People's Republic of China
  • 2Institute of Northeast General Pharmaceutical Factory, 37 Zhonggong Beijie, Shenyang, Liaoning 110026, People's Republic of China
  • 3Institute of Molecular and Cellular Biosciences, The Univeristy of Tokyo, Yayoi, Bunkyo-ku, Tokyo 113, Japan
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1996

1996

Publikationsdatum:
04. Januar 2007 (online)

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Abstract

By activity-guided fractionation, three known steroidal saponins, prosapogenin A of dioscin, dioscin and gracillin, were isolated from the total saponin fraction of Dioscorea collettii var. hypoglauca as active compounds causing morphological abnormality of Pyricularia oryzae mycelia. The compounds also exhibited cytotoxic activity against the cancer cell line K562 in vitro. The structures of the compounds were elucidated on the basis of chemical evidence and IR, FAB-MS, 1H-NMR, 13C-NMR, and two-dimensional NMR (2D-NMR) analysis.