Abstract
3-Benzyl-4-isopropyl-2(5H )-furanone,
which is a precursor to two naturally-occurring cytotoxic (Z )-5-ylidene-2(5H )-furanone
derivatives, has been conveniently prepared from 3,4-dibromo-2(5H )-furanone by a three-step procedure
involving two Pd-catalyzed cross-coupling reactions and a Rh(I)-catalyzed
hydrogenation.
Key words
2(5H )-furanones - cross-coupling - regioselectivity - Stille reaction - benzylation
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