Treatment of Malignancy by Activation of the Plasminogen System

Leo R. Zacharski; Deborah L. Ornstein; Esteban C. Gabazza; Corina N. D'Alessandro-Gabazza; Antonio Brugarolas; Jeffrey Schneider

doi:10.1055/s-2002-20560

Seminars in Thrombosis and Hemostasis, Inhaltsverzeichnis

Semin Thromb Hemost 2002; 28(1): 5-18
DOI: 10.1055/s-2002-20560

Treatment of Malignancy by Activation of the Plasminogen System

Leo R. Zacharski¹ , Deborah L. Ornstein² , Esteban C. Gabazza³ , Corina N. D'Alessandro-Gabazza³ , Antonio Brugarolas⁴ , Jeffrey Schneider⁵

¹VA Medical and Regional Office Center, White River Junction, Vermont and Department of Medicine, Dartmouth Medical School, Hanover, New Hampshire
²Division of Hematology/Oncology, Wilford Hall Medical Center, Lackland Air Force Base, Texas
³Third Department of Internal Medicine, Mie University School of Medicine, 514 Edobashi 2-chome 174, Tsu-city, Mie Prefecture, Japan
⁴Department of Oncology, Faculty of Medicine, University of Navarra, Pamplona, Spain
⁵222 Station Plaza North, Mineola, New York

Abstract

ABSTRACT

The blood coagulation mechanism in general and the plasminogen system in particular contribute to malignant growth and dissemination in complex ways. This article reviews the extensive literature that has accumulated over the past half-century on effects of plasminogen activation on the natural history of experimental animal and human malignancy. Although the potent enzymes generated upon plasminogen activation may have a direct effect on tumor cells, it is more likely that their mechanism of action is related to disruption of the tumor cell-extracellular matrix interaction. These observations suggest novel approaches to the experimental therapy of cancer.

KEYWORD

Malignancy - fibrinolysis - plasminogen activation - extracellular matrix

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