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CC BY-NC-ND 4.0 · Indian J Plast Surg 2024; 57(05): 356-363
DOI: 10.1055/s-0044-1779478
Original Article

Focuses and Trends of Research on Platelet-Rich Fibrin: A Bibliometric and Visual Analysis

Ying Zhao    *
1   Department of Anesthesiology and Perioperative Medicine, Xi'an People's Hospital (Xi'an Fourth Hospital), Northwest University, Xi'an, Shaanxi Province, China
,
Chen Dong   *
2   Department of Plastic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province, China
,
Liumeizi Fan
1   Department of Anesthesiology and Perioperative Medicine, Xi'an People's Hospital (Xi'an Fourth Hospital), Northwest University, Xi'an, Shaanxi Province, China
,
Ting Lei
1   Department of Anesthesiology and Perioperative Medicine, Xi'an People's Hospital (Xi'an Fourth Hospital), Northwest University, Xi'an, Shaanxi Province, China
,
Xin Ge
3   Department of Stomatology, Xi'an People's Hospital (Xi'an Fourth Hospital), Northwest University, Xi'an, Shaanxi Province, China
,
Zhou Yu
2   Department of Plastic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province, China
,
Sheng Hu
1   Department of Anesthesiology and Perioperative Medicine, Xi'an People's Hospital (Xi'an Fourth Hospital), Northwest University, Xi'an, Shaanxi Province, China
› Institutsangaben
Funding This study was supported by grants from the National Natural Science Foundation of China (81901052), Scientific research project of Xi'an Health Commission (2022qn04), and independent innovation and development project of Xi'an People's Hospital (Xi'an Fourth Hospital) (CX-29).
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Abstract

Background A rapid expansion of study on platelet-rich fibrin (PRF) has gained more attention in the subject. In this study, bibliometrics were used to assess the outputs and trends of relevant PRF studies. An in-depth analysis of the publication patterns and progress in PRF research worldwide was conducted for the purpose of filling in this research gap.

Materials and Methods The analysis included 946 papers sourced from Web of Science that included 842 original articles and 104 reviews. A number of factors including country/region, institution, journal, and author were taken into account. Research on PRF development trends was mapped using the frequency of keywords.

Results In terms of the total number of publications, China ranked first with 199 papers, whereas the United States ranked first on the H-index with 37. PRF is an active research area in stomatology and craniomaxillofacial surgery. Keywords provided by the authors were designated to three clusters: red, green, and blue. “Growth factor,” “platelet-rich plasma,” and “bone regeneration” were the most frequent keywords in each cluster, which reflect the current interests in corresponding fields. Bone regeneration post-dental extractions is one of the main application directions in the field of oral and maxillofacial surgery. “Membrane,” “injectable PRF (I-PRF),” “case report,” and “advanced PRF (A-PRF)” were relative recent keywords in all clusters, indicating that manufacturing processes and new applications are promising research hotspots in the field.

Conclusion In the future, the applications of modified PRF, such as I-PRF, are promising research hotspots. Moreover, strict randomized controlled trials on PRF deserve more attention. The results of this analysis may be helpful for all scholars seeking to expand researches and innovations in the field of PRF.

Keywords

bibliometric analysis - platelet-rich fibrin - growth factor - bone regeneration - membrane - injectable

Authors' Contributions

Y.Z. and C.D. drafted, proofread the manuscript, and prepared the figures. S.H. and Z.Y. edited the manuscript. X.G., T.L., and L.F. revised the manuscript. All authors have agreed upon the submission and publication of this work. Y.Z. and C.D. contribute equally to this review and should be considered cofirst authors.


* These authors have contributed equally to this work and share first authorship.


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Artikel online veröffentlicht:
11. September 2024

© 2024. Association of Plastic Surgeons of India. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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