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Semin Thromb Hemost 2022; 48(04): 422-433
DOI: 10.1055/s-0041-1740267
DOI: 10.1055/s-0041-1740267
Review Article
Venous Thromboembolism in Premature Neonates
Abstract
While the incidence of venous thromboembolism (VTE) is lower among children than adults, the newborn period is one of two bimodal peaks (along with adolescence) in VTE incidence in the pediatric population. Most VTE cases in neonates occur among critically ill neonates being managed in the neonatal intensive care unit, and most of these children are born premature. For this reason, the presentation, diagnosis, management, and outcomes of VTE among children born premature deserve special emphasis by pediatric hematologists, neonatologists, pharmacists, and other pediatric health care providers, as well as by the scientific community, and are described in this review.
Publikationsverlauf
Artikel online veröffentlicht:
23. Dezember 2021
© 2021. Thieme. All rights reserved.
Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA
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References
- 1 Monagle P, Newall F. Management of thrombosis in children and neonates: practical use of anticoagulants in children. Hematology (Am Soc Hematol Educ Program) 2018; 2018 (01) 399-404
- 2 Amankwah EK, Atchison CM, Arlikar S. et al. Risk factors for hospital-associated venous thromboembolism in the neonatal intensive care unit. Thromb Res 2014; 134 (02) 305-309
- 3 Heller C, Schobess R, Kurnik K. et al; For the Childhood Thrombophilia Study Group. Abdominal venous thrombosis in neonates and infants: role of prothrombotic risk factors - a multicentre case-control study. Br J Haematol 2000; 111 (02) 534-539
- 4 Morag I, Epelman M, Daneman A. et al. Portal vein thrombosis in the neonate: risk factors, course, and outcome. J Pediatr 2006; 148 (06) 735-739
- 5 van Elteren HA, Veldt HS, Te Pas AB. et al. Management and outcome in 32 neonates with thrombotic events. Int J Pediatr 2011; 2011: 217564
- 6 Raffini L, Huang Y-S, Witmer C, Feudtner C. Dramatic increase in venous thromboembolism in children's hospitals in the United States from 2001 to 2007. Pediatrics 2009; 124 (04) 1001-1008
- 7 Kenet G, Cohen O, Bajorat T, Nowak-Göttl U. Insights into neonatal thrombosis. Thromb Res 2019; 181 (Suppl. 01) S33-S36
- 8 Kenet G, Barg AA, Nowak-Göttl U. Hemostasis in the very young. Semin Thromb Hemost 2018; 44 (07) 617-623
- 9 Demirel N, Aydin M, Zenciroglu A. et al. Neonatal thrombo-embolism: risk factors, clinical features and outcome. Ann Trop Paediatr 2009; 29 (04) 271-279
- 10 Robinson V, Achey MA, Nag UP. et al. Thrombosis in infants in the neonatal intensive care unit: analysis of a large national database. J Thromb Haemost 2021; 19 (02) 400-407
- 11 Andrew M. Developmental hemostasis: relevance to thromboembolic complications in pediatric patients. Thromb Haemost 1995; 74 (01) 415-425
- 12 Tuckuviene R, Christensen AL, Helgested J, Hundborg HH, Kristensen SR, Johnsen SP. Infant, obstetrical and maternal characteristics associated with thromboembolism in infancy: a nationwide population-based case-control study. Arch Dis Child Fetal Neonatal Ed 2012; 97 (06) F417-F422
- 13 Strauss T, Levy-Shraga Y, Ravid B. et al. Clot formation of neonates tested by thromboelastography correlates with gestational age. Thromb Haemost 2010; 103 (02) 344-350
- 14 Cowman J, Quinn N, Geoghegan S. et al. Dynamic platelet function on von Willebrand factor is different in preterm neonates and full-term neonates: changes in neonatal platelet function. J Thromb Haemost 2016; 14 (10) 2027-2035
- 15 Michelson AD. Platelet function in the newborn. Semin Thromb Hemost 1998; 24 (06) 507-512
- 16 Linder N, Shenkman B, Levin E. et al. Deposition of whole blood platelets on extracellular matrix under flow conditions in preterm infants. Arch Dis Child Fetal Neonatal Ed 2002; 86 (02) F127-F130
- 17 Levy-Shraga Y, Maayan-Metzger A, Lubetsky A. et al. Platelet function of newborns as tested by cone and plate(let) analyzer correlates with gestational Age. Acta Haematol 2006; 115 (3-4): 152-156
- 18 Strauss T, Sidlik-Muskatel R, Kenet G. Developmental hemostasis: primary hemostasis and evaluation of platelet function in neonates. Semin Fetal Neonatal Med 2011; 16 (06) 301-304
- 19 Revel-Vilk S. The conundrum of neonatal coagulopathy. Hematology (Am Soc Hematol Educ Program) 2012; 2012: 450-454
- 20 Reverdiau-Moalic P, Delahousse B, Body G, Bardos P, Leroy J, Gruel Y. Evolution of blood coagulation activators and inhibitors in the healthy human fetus. Blood 1996; 88 (03) 900-906
- 21 Andrew M, Paes B, Milner R. et al. Development of the human coagulation system in the healthy premature infant. Blood 1988; 72 (05) 1651-1657
- 22 Andrew M, Paes B, Milner R. et al. Development of the human coagulation system in the full-term infant. Blood 1987; 70 (01) 165-172
- 23 Smith AA, Jacobson LJ, Miller BI, Hathaway WE, Manco-Johnson MJ. A new euglobulin clot lysis assay for global fibrinolysis. Thromb Res 2003; 112 (5-6): 329-337
- 24 Goldenberg NA, Hathaway WE, Jacobson L, Manco-Johnson MJ. A new global assay of coagulation and fibrinolysis. Thromb Res 2005; 116 (04) 345-356
- 25 Weisel JW, Litvinov RI. Fibrin formation, structure and properties. Subcell Biochem 2017; 82: 405-456
- 26 Swieringa F, Spronk HMH, Heemskerk JWM, van der Meijden PEJ. Integrating platelet and coagulation activation in fibrin clot formation. Res Pract Thromb Haemost 2018; 2 (03) 450-460
- 27
Versteeg HH,
Heemskerk JW,
Levi M,
Reitsma PH.
New fundamentals in hemostasis. Physiol Rev 2013; 93 (01) 327-358
MissingFormLabel
- 28 Saracco P, Vitale P, Scolfaro C, Pollio B, Pagliarino M, Timeus F. The coagulopathy in sepsis: significance and implications for treatment. Pediatr Rep 2011; 3 (04) e30
- 29
Levi M,
van der Poll T.
Coagulation and sepsis. Thromb Res 2017; 149: 38-44
MissingFormLabel
- 30 Bökenkamp A, von Kries R, Nowak-Göttl U, Göbel U, Hoyer PF. Neonatal renal venous thrombosis in Germany between 1992 and 1994: epidemiology, treatment and outcome. Eur J Pediatr 2000; 159 (1-2): 44-48
- 31 Saxonhouse MA, Manco-Johnson MJ. The evaluation and management of neonatal coagulation disorders. Semin Perinatol 2009; 33 (01) 52-65
- 32 Monagle P, Chan AKC, Goldenberg NA. et al. Antithrombotic therapy in neonates and children: antithrombotic therapy and prevention of thrombosis: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 2012; 141 (2, Suppl): e737S-e801S
- 33 Saxonhouse MA. Thrombosis in the neonatal intensive care unit. Clin Perinatol 2015; 42 (03) 651-673
- 34
Stoll BJ,
Hansen NI,
Bell EF.
et al;
Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal
Research Network.
Neonatal outcomes of extremely preterm infants from the NICHD Neonatal Research Network.
Pediatrics 2010; 126 (03) 443-456
MissingFormLabel
- 35 Sheth RD. Trends in incidence and severity of intraventricular hemorrhage. J Child Neurol 1998; 13 (06) 261-264
- 36 Monagle P, Cuello CA, Augustine C. et al. American Society of Hematology 2018 Guidelines for management of venous thromboembolism: treatment of pediatric venous thromboembolism. Blood Adv 2018; 2 (22) 3292-3316
- 37 El-Naggar W, Yoon EW, McMillan D. et al; Canadian Neonatal Network Investigators. Epidemiology of thrombosis in Canadian neonatal intensive care units. J Perinatol 2020; 40 (07) 1083-1090
- 38 Rivard GE, David M, Farrell C, Schwarz HP. Treatment of purpura fulminans in meningococcemia with protein C concentrate. J Pediatr 1995; 126 (04) 646-652
- 39 White B, Livingstone W, Murphy C, Hodgson A, Rafferty M, Smith OP. An open-label study of the role of adjuvant hemostatic support with protein C replacement therapy in purpura fulminans-associated meningococcemia. Blood 2000; 96 (12) 3719-3724
- 40 Lexicomp Online. Enoxaparin. https://online.lexi.com/lco/action/home . Accessed November 9, 2021
- 41 Bhandari M, Hirsh J, Weitz JI, Young E, Venner TJ, Shaughnessy SG. The effects of standard and low molecular weight heparin on bone nodule formation in vitro. Thromb Haemost 1998; 80 (03) 413-417
- 42
Garcia DA,
Baglin TP,
Weitz JI,
Samama MM.
Parenteral anticoagulants: antithrombotic therapy and prevention of thrombosis: American
College of Chest Physicians evidence-based clinical practice guidelines. Chest 2012;
141 (2, Suppl): e24S-e43S
MissingFormLabel
- 43 Bohnhoff JC, DiSilvio SA, Aneja RK. et al. Treatment and follow-up of venous thrombosis in the neonatal intensive care unit: a retrospective study. J Perinatol 2017; 37 (03) 306-310
- 44 Hicks JK, Shelton CM, Sahni JK, Christensen ML. Retrospective evaluation of enoxaparin dosing in patients 48 weeks' postmenstrual age or younger in a neonatal intensive care unit. Ann Pharmacother 2012; 46 (7-8): 943-951
- 45 Michaels LA, Gurian M, Hegyi T, Drachtman RA. Low molecular weight heparin in the treatment of venous and arterial thromboses in the premature infant. Pediatrics 2004; 114 (03) 703-707 d
- 46 Malowany JI, Monagle P, Knoppert DC. et al; Canadian Paediatric Thrombosis and Hemostasis Network. Enoxaparin for neonatal thrombosis: a call for a higher dose for neonates. Thromb Res 2008; 122 (06) 826-830
- 47 Bauman ME, Belletrutti MJ, Bajzar L. et al. Evaluation of enoxaparin dosing requirements in infants and children. Better dosing to achieve therapeutic levels. Thromb Haemost 2009; 101 (01) 86-92
- 48 Lexicomp Online. Protamine. https://online.lexi.com/lco/action/home . Accessed November 9, 2021
- 49 Giglia TM, Massicotte MP, Tweddell JS. et al; American Heart Association Congenital Heart Defects Committee of the Council on Cardiovascular Disease in the Young, Council on Cardiovascular and Stroke Nursing, Council on Epidemiology and Prevention, and Stroke Council. Prevention and treatment of thrombosis in pediatric and congenital heart disease: a scientific statement from the American Heart Association. Circulation 2013; 128 (24) 2622-2703
- 50 Andrew M, Marzinotto V, Massicotte P. et al. Heparin therapy in pediatric patients: a prospective cohort study. Pediatr Res 1994; 35 (01) 78-83
- 51 Alsoufi B, Boshkov LK, Kirby A. et al. Heparin-induced thrombocytopenia (HIT) in pediatric cardiac surgery: an emerging cause of morbidity and mortality. Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2004; 7: 155-171
- 52 Risch L, Huber AR, Schmugge M. Diagnosis and treatment of heparin-induced thrombocytopenia in neonates and children. Thromb Res 2006; 118 (01) 123-135
- 53 Schmugge M, Risch L, Huber AR, Benn A, Fischer JE. Heparin-induced thrombocytopenia-associated thrombosis in pediatric intensive care patients. Pediatrics 2002; 109 (01) E10
- 54 Lexicomp Online. Warfarin Hudson, OH Lexicomp. Accessed November 9, 2021 at: https://online.lexi.com/lco/action/home
- 55 Giglia TM, Witmer C, Procaccini DE, Byrnes JW. Pediatric cardiac intensive care society 2014 consensus statement: pharmacotherapies in cardiac critical care anticoagulation and thrombolysis. Pediatr Crit Care Med 2016; 17 (3, Suppl 1): S77-S88
- 56 Iyengar AJ, Winlaw DS, Galati JC. et al; Australia and New Zealand Fontan Registry. No difference between aspirin and warfarin after extracardiac Fontan in a propensity score analysis of 475 patients. Eur J Cardiothorac Surg 2016; 50 (05) 980-987
- 57 Monagle P, Cochrane A, Roberts R. et al; Fontan Anticoagulation Study Group. A multicenter, randomized trial comparing heparin/warfarin and acetylsalicylic acid as primary thromboprophylaxis for 2 years after the Fontan procedure in children. J Am Coll Cardiol 2011; 58 (06) 645-651
- 58 Lexicomp Online. Argatroban. https://online.lexi.com/lco/action/home . Accessed November 9, 2021
- 59 Lexicomp Online. Bivalirudin. https://online.lexi.com/lco/action/home . Accessed November 9, 2021
- 60 Young G, Boshkov LK, Sullivan JE. et al. Argatroban therapy in pediatric patients requiring nonheparin anticoagulation: an open-label, safety, efficacy, and pharmacokinetic study. Pediatr Blood Cancer 2011; 56 (07) 1103-1109
- 61 O'Brien SH, Yee DL, Lira J, Goldenberg NA, Young G. UNBLOCK: an open-label, dose-finding, pharmacokinetic and safety study of bivalirudin in children with deep vein thrombosis. J Thromb Haemost 2015; 13 (09) 1615-1622
- 62 Rayapudi S, Torres Jr A, Deshpande GG. et al. Bivalirudin for anticoagulation in children. Pediatr Blood Cancer 2008; 51 (06) 798-801
- 63 Young G, Tarantino MD, Wohrley J, Weber LC, Belvedere M, Nugent DJ. Pilot dose-finding and safety study of bivalirudin in infants <6 months of age with thrombosis. J Thromb Haemost 2007; 5 (08) 1654-1659
- 64 Tarango C, Manco-Johnson MJ. Pediatric thrombolysis: a practical approach. Front Pediatr 2017; 5: 260
- 65 Manco-Johnson MJ. How I treat venous thrombosis in children. Blood 2006; 107 (01) 21-29
- 66 El-Segaier M, Khan MA, Khan ZU, Momenah T, Galal MO. Recombinant tissue plasminogen activator in the treatment of neonates with intracardiac and great vessels thrombosis. Pediatr Cardiol 2015; 36 (08) 1582-1587
- 67 Hartmann J, Hussein A, Trowitzsch E, Becker J, Hennecke KH. Treatment of neonatal thrombus formation with recombinant tissue plasminogen activator: six years experience and review of the literature. Arch Dis Child Fetal Neonatal Ed 2001; 85 (01) F18-F22
- 68 Schmidt B, Andrew M. Neonatal thrombosis: report of a prospective Canadian and international registry. Pediatrics 1995; 96 (5 Pt 1): 939-943
- 69 Andrew M, David M, Adams M. et al. Venous thromboembolic complications (VTE) in children: first analyses of the Canadian Registry of VTE. Blood 1994; 83 (05) 1251-1257
- 70 Kahn SR, Shrier I, Julian JA. et al. Determinants and time course of the postthrombotic syndrome after acute deep venous thrombosis. Ann Intern Med 2008; 149 (10) 698-707
- 71 Prandoni P, Lensing AW, Cogo A. et al. The long-term clinical course of acute deep venous thrombosis. Ann Intern Med 1996; 125 (01) 1-7
- 72 Goldenberg NA, Donadini MP, Kahn SR. et al. Post-thrombotic syndrome in children: a systematic review of frequency of occurrence, validity of outcome measures, and prognostic factors. Haematologica 2010; 95 (11) 1952-1959
- 73 Engel ER, Nguyen ATH, Amankwah EK. et al. Predictors of postthrombotic syndrome in pediatric thrombosis: a systematic review and meta-analysis of the literature. J Thromb Haemost 2020; 18 (10) 2601-2612
- 74 Keidan I, Lotan D, Gazit G, Boichis H, Reichman B, Linder N. Early neonatal renal venous thrombosis: long-term outcome. Acta Paediatr 1994; 83 (11) 1225-1227
- 75 Zigman A, Yazbeck S, Emil S, Nguyen L. Renal vein thrombosis: a 10-year review. J Pediatr Surg 2000; 35 (11) 1540-1542
- 76 Kayemba-Kay's S. Spontaneous neonatal renal vein thrombosis, a known pathology without clear management guidelines: an overview. Int J Pediatr Adolesc Med 2020; 7 (01) 31-35
- 77 Messinger Y, Sheaffer JW, Mrozek J, Smith CM, Sinaiko AR. Renal outcome of neonatal renal venous thrombosis: review of 28 patients and effectiveness of fibrinolytics and heparin in 10 patients. Pediatrics 2006; 118 (05) e1478-e1484
- 78 Wasay M, Dai AI, Ansari M, Shaikh Z, Roach ES. Cerebral venous sinus thrombosis in children: a multicenter cohort from the United States. J Child Neurol 2008; 23 (01) 26-31
- 79 Moharir MD, Shroff M, Stephens D. et al. Anticoagulants in pediatric cerebral sinovenous thrombosis: a safety and outcome study. Ann Neurol 2010; 67 (05) 590-599
- 80 Moharir MD, Shroff M, Pontigon A-M. et al. A prospective outcome study of neonatal cerebral sinovenous thrombosis. J Child Neurol 2011; 26 (09) 1137-1144
- 81 Berfelo FJ, Kersbergen KJ, van Ommen CH. et al. Neonatal cerebral sinovenous thrombosis from symptom to outcome. Stroke 2010; 41 (07) 1382-1388
- 82 Jordan LC, Rafay MF, Smith SE. et al; International Pediatric Stroke Study Group. Antithrombotic treatment in neonatal cerebral sinovenous thrombosis: results of the International Pediatric Stroke Study. J Pediatr 2010; 156 (05) 704-710 , 710.e1–710.e2
- 83 Devlieger H, Snoeys R, Wyndaele L. et al. Liver necrosis in the new-born infant: analysis of some precipitating factors in neonatal care. Eur J Pediatr 1982; 138 (02) 113-119
- 84 Kim JH, Lee YS, Kim SH, Lee S-K, Lim MK, Kim HS. Does umbilical vein catheterization lead to portal venous thrombosis? Prospective US evaluation in 100 neonates. Radiology 2001; 219 (03) 645-650
- 85 Morag I, Shah PS, Epelman M, Daneman A, Strauss T, Moore AM. Childhood outcomes of neonates diagnosed with portal vein thrombosis. J Paediatr Child Health 2011; 47 (06) 356-360