Summary
In this longitudinal study we measured β-TG, PF4, fibrinolytic activity (extrinsic
and euglobulin fraction), fibrinogen, FVIII RAg and FVIII Rcof before and after i.v.
DDAVP (FPA was only measured before DDAVP) in 20 patients with diabetes mellitus.
These parameters were measured on three occasions: phase I: during disregulation,
phase II: after three weeks of strict control, phase III: after nine weeks of good
control. Twenty-two healthy volunteers served as normal controls.
No significant differences related to metabolic control were found for β-TG, PF4,
FPA and fibrinogen. There was no change after i.v. DDAVP administration. Fibrinolytic
activity showed a significant increase after i.v. DDAVP. Baseline values and post-DDAVP
increase were not significantly different from our normal controls.
FVIII RAg and FVIII Rcof were both significantly elevated in diabetes mellitus. Both
increased significantly after DDAVP. The FVIII RAg release (ΔFVIII RAg) was significantly
less in the diabetics. Fibrinolytic activity, FVIII RAg and FVIII Rcof are independent
of the degree of metabolic control in patients with diabetes.
Key words
Platelets - Fibrinolysis - Coagulation tests - Fibrinolysis - Diabetes mellitus -
DDAVP
