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Thromb Haemost 1982; 48(02): 125-126
DOI: 10.1055/s-0038-1657239
Original Article
Schattauer GmbH Stuttgart

Effect of Aspirin on Platelet 5-Hydroxytryptamine and Beta-Thromboglobulin Plasma Levels in Patients with Myeloproliferative Diseases

P Viero
The Division of Haematology, Ospedali Riuniti, Bergamo
,
S Cortelazzo
*   The Division of Haematology, Ospedale Generale Regionale, Vicenza, Italy
,
R Bassan
The Division of Haematology, Ospedali Riuniti, Bergamo
,
T Barbui
The Division of Haematology, Ospedali Riuniti, Bergamo
› Author Affiliations
Further Information

Publication History

Received 15 January 1982

Accepted 29 June 1982

Publication Date:
13 July 2018 (online)

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Summary

14 patients with myeloproliferative diseases (MD) showed low 5-hydroxytryptamine (5-HT) platelet content and high beta-thromboglobulin (β-TG) plasma levels.

This pattern could support the view that MD platelets undergo “in vivo“ degranulation.

A single dose of aspirin was unable to induce modification of platelet 5-HT and plasma β-TG, whereas 6 out of 14 patients

No modification of platelet 5-HT was obtained suggesting that the cause of dense bodies deficiency may lie in the production of abnormal platelets and not be related to “in vivo” degranulation.

Keywords

Platelets - Myeloproliferative diseases - Beta-thromboglobulin - 5-hydroxytryptamine - Aspirin
 

  • References

  • 1 Cortelazzo S, Viero P, Bassan R, Barbui T. Spectrum of platelet aggregation abnormalities in myeloproliferative diseases. La Ricerca in Clin e Lab 1981; 11: 35-42
    PubMedSearch in Google Scholar
  • 2 Okuma M, Uchino H. Altered arachidonate metabolism by platelets in patients with myeloproliferative disorders. Blood 1979; 54: 1258-1271
    PubMedSearch in Google Scholar
  • 3 Pareti FI, Mannucci PM, Asti D, Guarini A, Gugliotta L, Tura S. Acquired storage pool disease in myeloproliferative disorders. Thromb Haemostas 1979; 42: 44 (Abstr.)
    PubMedSearch in Google Scholar
  • 4 Parbtani A, Cameron JS. Platelet and plasma serotonin concentration in glomerulonephritis I. Thromb Res 1979; 15: 109-125
    CrossrefPubMedSearch in Google Scholar
  • 5 Zahavi J, Kakkar VV. β-thromboglobulin - a specific marker of in vivo platelet release reaction. Thromb Haemostas 1980; 44: 23-29
    PubMedSearch in Google Scholar
  • 6 Drummond A, Gordon JL. Rapid, sensitive microassay for platelet 5-HT. Thrombos Diathes Haemorrh 1974; 31: 366
    PubMedSearch in Google Scholar
  • 7 Villa S, Livio M, de Gaetano G. The inhibitory effect of aspirin on platelet and vascular prostaglandins in rats cannot be completely dissociated. Br J Haematol 1979; 42: 425-431
    CrossrefPubMedSearch in Google Scholar
  • 8 Cortelazzo S, Viero P, Barbui T. Platelet activation in myeloproliferative disorders. Thromb Haemostas 1981; 45: 211-213
    PubMedSearch in Google Scholar
  • 9 Boughton BJ, Allington MJ, King A. Platelet and plasma thrombo-globulin in myeloproliferative syndromes and secondary thrombocytosis. Br J Haematol 1978; 40: 125-132
    CrossrefPubMedSearch in Google Scholar