Detection of the Factor V Leiden Mutation Using Whole Blood PCR

• References

• 1 Bertina RM, Koeleman BPC, Koster T, Rosendaal FR, Dirven RJ, de Ronde H, Van Der Velden PA, Reitsma PH. Mutation in blood coagulation factor V associated with resistance to activated protein. C. Nature 1994; 369: 64-67
• 2 Rees DC, Cox M, Clegg JB. World distribution of factor V Leiden. Lancet 1995; 346: 1133-1134
• 3 Koeleman BPC, Reitsma PH, Allaart CF, Bertina RM. Activated protein C resistance as an additional risk factor for thrombosis in protein C-deficient families. Blood 1994; 84: 1031-1035
• 4 McCusker J, Dawson MT, Noone D, Gannon F, Smith T. Improved method for direct PCR amplification from whole blood. Nucleic Acid Research 1992; 20 (24) 6747