Thromb Haemost 1995; 74(06): 1607-1609
DOI: 10.1055/s-0038-1649991
Letter to the Editor
Schattauer GmbH Stuttgart

Heparin-Induced Thrombocytopenia: Discrepancy between the Presence of IgG Cross-Reacting In Vitro with Fraxiparine and Its Successful Clinical Use

Authors

  • Guido Luzzatto

    Patologia Medica II, Padua University School of Medicine, Via Niccolò Giustiniani 2,35128 Padova, Italy
  • Immacolata Cordiano

    Patologia Medica II, Padua University School of Medicine, Via Niccolò Giustiniani 2,35128 Padova, Italy
  • Giovanni Patrassi

    Patologia Medica II, Padua University School of Medicine, Via Niccolò Giustiniani 2,35128 Padova, Italy
  • Fabrizio Fabris

    Patologia Medica II, Padua University School of Medicine, Via Niccolò Giustiniani 2,35128 Padova, Italy
Further Information

Publication History

Received 07 June 1995

Accepted after revision 18 August 1995

Publication Date:
10 July 2018 (online)

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  • References

  • 1 Aster RH. Heparin-induced thrombocytopenia and thrombosis. N Engl J Med 1995; 332: 1374-1376
  • 2 Amiral J, Bridey F, Dreyfus M, Vissac AM, Fressinaud E, Wolf M, Meyer D. Platelet factor 4 complexed to heparin is the target for antibodies generated in heparin-induced thrombocytopenia. Thromb Haemost 1992; 68: 95-96
  • 3 Greinacher A, Amiral J, Dummel V, Vissac A, Kiefel V, Mueller-Eckardt C. Laboratory diagnosis of heparin-associated thrombocytopenia and comparison of platelet aggregation test, heparin-induced aggregation test and platelet factor 4-heparin enzyme linked immunosorbent assay. Transfusion 1994; 34: 381-354
  • 4 Visentin GP, Ford SE, Scott JP, Aster RH. Antibodies from patients with heparin-induced thrombocytopenia/thrombosis are specific for platelet factor 4 complexed with heparin or bound to endothelial cells. J Clin Invest 1994; 93: 81-88
  • 5 Amiral J, Bridey F, Wolf M, Boyer-Neumann C, Fressinaud E, Vissac AM, Peynaud-Debayle E, Dreyfus M, Meyer D. Antibodies to macromolecular platelet factor 4-heparin complexes in heparin-induced thrombocytopenia: a study of 44 cases. Thromb Haemost 1995; 73: 21-28
  • 6 Chong BH, Ismail F, Cade J, Gallus AS, Gordon S, Chesterman CN. Heparin-induced thrombocytopenia: studies with a new low molecular weight heparinoid, Org 10172. Blood 1989; 73: 1592-1596
  • 7 Greinacher A, Michels I, Mueller-Eckardt C. Heparin-associated thrombocytopenia: the antibody is not heparin specific. Thromb Haemost 1992; 67: 545-549
  • 8 Demers C, Ginsberg JS, Brill-Edwards P, Panju A, Warkentin TE, Anderson DR, Turner C, Kelton JG. Rapid anticoagulation using ancrod for heparin-induced thrombocytopenia. Blood 1991; 78: 2194-2197
  • 9 Cadroy Y, Amiral J, Raynaud H, Brunel P, Mazaleyrat A, Sauer M, Sié P. Evolution of antibodies anti-PF4/heparinin a patient with a history of heparin-induced thrombocytopenia re-exposed to heparin. Thromb Haemost 1994; 72: 782-786
  • 10 Patrassi GM, Luzzatto G. Heparin-induced thrombocytopenia with thrombosis of the aorta, iliac arteries and right axillary vein successfully treated by low-molecular weight heparin. Acta Haematol 1994; 91: 55-56
  • 11 Ortel TL, Gockerman JP, Califf RM, McCann RL, O’Connor CM, Metzler DM, Greenberg CS. Parenteral anticoagulation with the heparinoid Lomo- paran (Org 10172) in patients with heparin induced thrombocytopenia and thrombosis. Thromb Haemost 1992; 67: 292-296
  • 12 Fabris F, Cordiano I, Salvan F, Saggin L, Cella G, Luzzatto G, Girolami A. Heparin-induced thrombocytopenia and thrombosis: prevalence in a large cohort of patients and evidence that PF4/heparin complex is the main antigen for antibodies. Submitted for publication
  • 13 Greinacher A, Potzsch B, Amiral J, Dummel V, Eicher A, Mueller-Eckardt C. Heparin-associated thrombocytopenia: isolation of the antibody and characterization of amultimolecular PF4-heparin complex as the major antigen. Thromb Haemost 1994; 7: 247-251
  • 14 Pernod G, Duret J, Pouzol P, Charlet JP, Skolka I, Peyrin JC, Kolodie L. Thrombopénie induite par I’héparine: discordance entre I’efficacité clinique de I’énoxaparine et les test d’aggrégation plaquettaire in vitro. Presse Méd 1993; 22 15 737