Thromb Haemost 1978; 39(03): 657-662
DOI: 10.1055/s-0038-1646740
Original Article
Schattauer GmbH Stuttgart

Comparison of Factor VIII Levels after Adrenalin in Classic Hemophilia and von Willebrand’s Disease (vWd)[*]

Authors

  • M Elaine Eyster

    1   The Division of Hematology, Departement of Medicine, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, U.S.A.
  • James O Ballard

    1   The Division of Hematology, Departement of Medicine, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, U.S.A.
  • David Prager

    1   The Division of Hematology, Departement of Medicine, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, U.S.A.
Further Information

Publication History

Received 19 October 1977

Accepted 22 November 1977

Publication Date:
26 July 2018 (online)

Preview

Summary

The factor VIII response to adrenalin was compared in 5 patients with von Willebrand’s disease (vWd) and 10 hemophiliacs with baseline factor VIII procoagulant activity (VIIIAHF) of 0.01 u/ml or greater. Patients with vWd showed a two-fold VIII AHF increase, while those with hemophilia showed no significant change 1 hr following the subcutaneous injection of adrenalin. These results suggest that the adrenalin stimulation test may be of value in distinguishing certain patients with mild hemophilia from those with vWd.

* Presented at the XII Congress of the World Federation of Haemophilia, New York, June 22-25, 1977