Antibacterial Sesquiterpenoid Derivatives from Ferula
                        ferulaeoides

Tao Liu; Khadijo Osman; Glenn W. Kaatz; Simon Gibbons; Qing Mu

doi:10.1055/s-0032-1328461

Planta Medica, Inhaltsverzeichnis

Planta Med 2013; 79(08): 701-706
DOI: 10.1055/s-0032-1328461

Natural Product Chemistry

Letters

Georg Thieme Verlag KG Stuttgart · New York

Antibacterial Sesquiterpenoid Derivatives from Ferula ferulaeoides

Authors

Tao Liu

¹School of Pharmacy, Fudan University, Shanghai, China
Khadijo Osman

²Department of Pharmaceutical and Biological Chemistry, UCL School of Pharmacy, London, United Kingdom
Glenn W. Kaatz

³The John D. Dingell Department of Veteranʼs Affairs Medical Center and Department of Internal Medicine, Division of Infectious Diseases, School of Medicine, Wayne State University, Detroit, Michigan, USA
Simon Gibbons

²Department of Pharmaceutical and Biological Chemistry, UCL School of Pharmacy, London, United Kingdom
Qing Mu

¹School of Pharmacy, Fudan University, Shanghai, China

Abstract

Three new sesquiterpenoid derivatives 1, 2, and 3 were isolated from Ferula ferulaeoides. To confirm the structure, compound 2 was also synthesized via a condensation reaction between compound 1 and 2,2-dimethoxypropane. The structures of these three compounds were elucidated by means of spectroscopic and chemical methods. Their antibacterial activity against drug-resistant Staphylococcus aureus strains were evaluated with MIC values in the range of 0.5–128 µg/mL. Compounds 1 and 3 were capable of inhibiting efflux of ethidium bromide using an in vitro assay. The cytotoxicity of the compounds was evaluated on cultured HEK293 cells, and none of them showed toxicity to HEK293 cells at a concentration of 125 µg/mL.

Key words

Ferula ferulaeoides - Apiaceae - sesquiterpenoid - efflux inhibition - drug-resistant Staphylococcus aureus

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Referenzen

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