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Arzneimittelforschung 2006; 56(9): 621-625
DOI: 10.1055/s-0031-1296762
Antidiabetics
Editio Cantor Verlag Aulendorf (Germany)

Synthesis and Antidiabetic Activity of Novel 2,4-Thiazolidinedione Derivatives Containing a Thiazole Ring

Authors

  • Oya Bozdağ-Dündar

    1   Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Tandog˘an, Ankara, Turkey

  • Meltem Ceylan-Ünlüsoy

    1   Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Tandog˘an, Ankara, Turkey

  • Verspohl J. Eugen

    2   Department of Pharmacology, Institute of Medicinal Chemistry, Münster University, Münster, Germany

  • Rahmiye Ertan

    1   Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Tandog˘an, Ankara, Turkey
Further Information

Publication History

Publication Date:
22 December 2011 (online)

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Summary

A series of thiazolyl-2,4-thiazolidine-diones (Ia-f, IIa-f and IIIa-f) was prepared by Knoevenagel reaction of substituted benzyl-2,4-thiazolidinediones (4a-f) with chlorothiazolecarbaldehydes (2, 3a-b). The prepared compounds were tested for their insulinotropic activities in INS-1 cells.. A significant insulinotropic effect was seen with compounds If and IIa.

Zusammenfassung

Darstellung und antidiabetische Wirkung neuer 2,4-Thiazolidindion-Derivate mit einem Thiazol-Ring

Eine Serie von Thiazolyl-2,4-thiazoli-dindionen (Ia-f, IIa-f und IIIa-f) wurden mit Hilfe der Knoevenagel Reaktion von substiutierten Benzyl-2,4-thiazolidindio-nen (4a-f) mit Chlorthiazocarbaldehyden (2, 3a-b) synthetisiert. Die biologische Aktivität wurde bzgl. der Insulinsekretion an INS-1-Zellen.getestet. Einen deutlichen insulinotropen Effekt besitzen If und IIa.

Key words

Antidiabetics - 2,4-Thiazolidinediones, antidiabetic activities, synthesis, thiazole derivatives