Semin Thromb Hemost 2010; 36(8): 917-924
DOI: 10.1055/s-0030-1267045
© Thieme Medical Publishers

Role of Microparticles in the Hemostatic Dysfunction in Acute Promyelocytic Leukemia

Hau C. Kwaan1 , Eduardo Magalhães Rego2
  • 1Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois
  • 2Division of Hematology/Oncology, Department of Internal Medicine, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil
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Publikationsdatum:
03. November 2010 (online)

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ABSTRACT

Serious bleeding and thrombotic complications are frequent in acute promyelocytic leukemia (APL) and are major causes of morbidity and mortality. Microparticles (MP) have been used to study the risk and pathogenesis of thrombosis in many malignant disorders. To date, from published articles, this approach had not been applied to APL. In this article, the hemostatic dysfunction in this disorder is briefly reviewed. A study design to address this problem using MP is described. MP bearing tissue factor, profibrinolytic factors (tissue plasminogen activator and annexin A2), and the antifibrinolytic factor plasminogen activator inhibitor type 1 were measured using flow cytometry. The cellular origin of the MP was identified by specific cell surface markers. Comparison of the various populations of MP was made between samples collected at the time of diagnosis with those collected at molecular remission. Preliminary data suggest that this approach is feasible.

REFERENCES

Hau C KwaanM.D. Ph.D. 

Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Olson Pavilion

303 East Chicago Avenue, Chicago, IL 60611

eMail: h-kwaan@northwestern.edu