S3-Leitlinie Pankreatitis – Leitlinie der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS)^[1] – September 2021 – AWMF Registernummer 021-003

Schlüsselwörter

akute Pankreatitis - chronische Pankreatitis - Schmerztherapie - Diagnose - Therapie - Epidemiologie - Klassifizierung - Autoimmune Pankreatitis

¹ Diese Leitlinie möchten wir Herrn Professor Wolfgang Huber widmen – einem Pankreatologen mit Herzblut, der uns viel zu früh verlassen hat.

^* beide Autoren teilen sich die Erstautorenschaft

^# beide Autoren teilen sich die Letztautorenschaft

Publication History

Received: 15 October 2021

Accepted: 10 January 2022

Article published online:
09 March 2022

• Literatur

• 1 Hoffmeister A, Mayerle J, Beglinger C. et al. S3-Consensus guidelines on definition, etiology, diagnosis and medical, endoscopic and surgical management of chronic pancreatitis German Society of Digestive and Metabolic Diseases (DGVS). Z Gastroenterol 2012; 50: 1176-1224
• 2 Working Group IAPAPAAPG. IAP/APA evidence-based guidelines for the management of acute pancreatitis. Pancreatology 2013; 13: e1-e15
• 3 Whitcomb DC, Shimosegawa T, Chari ST. et al. International consensus statements on early chronic Pancreatitis. Recommendations from the working group for the international consensus guidelines for chronic pancreatitis in collaboration with The International Association of Pancreatology, American Pancreatic Association, Japan Pancreas Society, PancreasFest Working Group and European Pancreatic Club. Pancreatology 2018;
• 4 Löhr JM, Beuers U, Vujasinovic M. et al. European Guideline on IgG4-related digestive disease – UEG and SGF evidence-based recommendations. United European Gastroenterol J 2020; 8: 637-666
• 5 OCEBM Levels of Evidence Working Group = Jeremy Howick ICJLL, Paul Glasziou, Trish Greenhalgh, Carl Heneghan, Alessandro Liberati, Ivan Moschetti, Bob Phillips, Hazel Thornton, Olive Goddard and Mary Hodgkinson. OCEBM Levels of Evidence Working Group*. “The Oxford Levels of Evidence 2”. 2011
• 6 Peery AF, Crockett SD, Murphy CC. et al. Burden and Cost of Gastrointestinal, Liver, and Pancreatic Diseases in the United States: Update 2018. Gastroenterology 2019; 156: 254-272 e211
• 7 Oskarsson V, Hosseini S, Discacciati A. et al. Rising incidence of acute pancreatitis in Sweden: National estimates and trends between 1990 and 2013. United European Gastroenterol J 2020;
• 8 Schepers NJ, Bakker OJ, Besselink MG. et al. Impact of characteristics of organ failure and infected necrosis on mortality in necrotising pancreatitis. Gut 2019; 68: 1044-1051
• 9 Guda NM, Muddana V, Whitcomb DC. et al. Recurrent Acute Pancreatitis: International State-of-the-Science Conference With Recommendations. Pancreas 2018; 47: 653-666
• 10 Khurana V, Ganguly I. Recurrent acute pancreatitis. Jop 2014; 15: 413-426
• 11 Parniczky A, Abu-El-Haija M, Husain S. et al. EPC/HPSG evidence-based guidelines for the management of pediatric pancreatitis. Pancreatology 2018; 18: 146-160
• 12 Mariani A. Chronic asymptomatic pancreatic hyperenzymemia: is it a benign anomaly or a disease?. In Jop. Italy 2010; 11: 95-98
• 13 Di Leo M, Petrone MC, Zuppardo RA. et al. Pancreatic morpho-functional imaging as a diagnostic approach for chronic asymptomatic pancreatic hyperenzymemia. Dig Liver Dis 2016; 48: 1330-1335
• 14 Amodio A, De Marchi G, Granato A. et al. Chronic Asymptomatic Pancreatic Hyperenzymemia: A Long-term Follow-up. Pancreas 2019; 48: 544-547
• 15 Weiss FU, Schurmann C, Guenther A. et al. Fucosyltransferase 2 (FUT2) non-secretor status and blood group B are associated with elevated serum lipase activity in asymptomatic subjects, and an increased risk for chronic pancreatitis: a genetic association study. Gut 2015; 64: 646-656
• 16 Lankisch PG, Apte M, Banks PA. Acute pancreatitis. Lancet (London, England) 2015; 386: 85-96
• 17 Lankisch PG, Lowenfels AB, Maisonneuve P. What is the risk of alcoholic pancreatitis in heavy drinkers?. In Pancreas. United States 2002: 411-412
• 18 Rünzi M, Saluja A, Lerch MM. et al. Early ductal decompression prevents the progression of biliary pancreatitis: an experimental study in the opossum. Gastroenterology 1993; 105: 157-164
• 19 Weiss FU, Laemmerhirt F, Lerch MM. Etiology and Risk Factors of Acute and Chronic Pancreatitis. Visc Med 2019; 35: 73-81
• 20 Banks PA, Bollen TL, Dervenis C. et al. Classification of acute pancreatitis--2012: revision of the Atlanta classification and definitions by international consensus. Gut 2013; 62: 102-111
• 21 Pedersen SB, Langsted A, Nordestgaard BG. Nonfasting Mild-to-Moderate Hypertriglyceridemia and Risk of Acute Pancreatitis. JAMA Intern Med 2016; 176: 1834-1842
• 22 Witztum JL, Gaudet D, Freedman SD. et al. Volanesorsen and Triglyceride Levels in Familial Chylomicronemia Syndrome. N Engl J Med 2019; 381: 531-542
• 23 Dumonceau JM, Andriulli A, Elmunzer BJ. et al. Prophylaxis of post-ERCP pancreatitis: European Society of Gastrointestinal Endoscopy (ESGE) Guideline – updated June 2014. Endoscopy 2014; 46: 799-815
• 24 Aktas H, de Ridder L, Haringsma J. et al. Complications of single-balloon enteroscopy: a prospective evaluation of 166 procedures. Endoscopy 2010; 42: 365-368
• 25 Aktas H, Mensink PB, Haringsma J. et al. Low incidence of hyperamylasemia after proximal double-balloon enteroscopy: has the insertion technique improved?. Endoscopy 2009; 41: 670-673
• 26 Tian G, Ye Z, Zhao Q. et al. Complication incidence of EUS-guided pancreas biopsy: A systematic review and meta-analysis of 11 thousand population from 78 cohort studies. Asian journal of surgery 2020; 43: 1049-1055
• 27 Sun X, Huang X, Zhao R. et al. Meta-analysis: Tobacco smoking may enhance the risk of acute pancreatitis. Pancreatology 2015; 15: 286-294
• 28 Sadr-Azodi O, Andrén-Sandberg Å, Orsini N. et al. Cigarette smoking, smoking cessation and acute pancreatitis: a prospective population-based study. Gut 2012; 61: 262-267
• 29 Yang L, He Z, Tang X. et al. Type 2 diabetes mellitus and the risk of acute pancreatitis: a meta-analysis. Eur J Gastroenterol Hepatol 2013; 25: 225-231
• 30 Oskarsson V, Sadr-Azodi O, Orsini N. et al. High dietary glycemic load increases the risk of non-gallstone-related acute pancreatitis: a prospective cohort study. Clin Gastroenterol Hepatol 2014; 12: 676-682
• 31 Nitsche CJ, Jamieson N, Lerch MM. et al. Drug induced pancreatitis. Best Pract Res Clin Gastroenterol 2010; 24: 143-155
• 32 Badalov N, Baradarian R, Iswara K. et al Drug-induced acute pancreatitis: an evidence-based review. Clin Gastroenterol Hepatol 2007; 5: 648-661 ; quiz 644
• 33 Teich N, Mohl W, Bokemeyer B. et al. Azathioprine-induced Acute Pancreatitis in Patients with Inflammatory Bowel Diseases--A Prospective Study on Incidence and Severity. J Crohns Colitis 2016; 10: 61-68
• 34 Teich N, Bruns T, Stallmach A. Letter: predicting azathioprine-associated pancreatitis in IBD-phenotype or genotype?. Aliment Pharmacol Ther 2018; 47: 1042-1043
• 35 George J, Bajaj D, Sankaramangalam K. et al. Incidence of pancreatitis with the use of immune checkpoint inhibitors (ICI) in advanced cancers: A systematic review and meta-analysis. Pancreatology 2019; 19: 587-594
• 36 Alves C, Batel-Marques F, Macedo AF. A meta-analysis of serious adverse events reported with exenatide and liraglutide: acute pancreatitis and cancer. Diabetes Res Clin Pract 2012; 98: 271-284
• 37 Steinberg WM, Buse JB, Ghorbani MLM. et al. Amylase, Lipase, and Acute Pancreatitis in People With Type 2 Diabetes Treated With Liraglutide: Results From the LEADER Randomized Trial. Diabetes Care 2017; 40: 966-972
• 38 Azoulay L, Filion KB, Platt RW. et al. Association Between Incretin-Based Drugs and the Risk of Acute Pancreatitis. JAMA Intern Med 2016; 176: 1464-1473
• 39 Chen S, Zhao E, Li W. et al. Association between dipeptidyl peptidase-4 inhibitor drugs and risk of acute pancreatitis: A meta-analysis. Medicine (Baltimore) 2017; 96: e8952
• 40 Roshanov PS, Dennis BB. Incretin-based therapies are associated with acute pancreatitis: Meta-analysis of large randomized controlled trials. Diabetes Res Clin Pract 2015; 110: e13-e17
• 41 Monami M, Dicembrini I, Martelli D. et al. Safety of dipeptidyl peptidase-4 inhibitors: a meta-analysis of randomized clinical trials. Curr Med Res Opin 2011; 27 (Suppl. 03) 57-64
• 42 Rawla P, Bandaru SS, Vellipuram AR. Review of Infectious Etiology of Acute Pancreatitis. Gastroenterology Res 2017; 10: 153-158
• 43 Lai SW, Lin CL, Liao KF. et al. Increased risk of acute pancreatitis following pneumococcal pneumonia: a nationwide cohort study. Int J Clin Pract 2015; 69: 611-617
• 44 Chen YT, Su JS, Tseng CW. et al. Inflammatory bowel disease on the risk of acute pancreatitis: A population-based cohort study. J Gastroenterol Hepatol 2016; 31: 782-787
• 45 Haffar S, Bazerbachi F, Prokop L. et al. Frequency and prognosis of acute pancreatitis associated with fulminant or non-fulminant acute hepatitis A: A systematic review. Pancreatology 2017; 17: 166-175
• 46 Panic N, Mihajlovic S, Vujasinovic M. et al. Pancreatitis Associated with Viral Hepatitis: Systematic Review. Journal of clinical medicine 2020; 9: 3309
• 47 Oskarsson V, Sadr-Azodi O, Orsini N. et al. Vegetables, fruit and risk of non-gallstone-related acute pancreatitis: a population-based prospective cohort study. Gut 2013; 62: 1187-1192
• 48 Oskarsson V, Orsini N, Sadr-Azodi O. et al. Fish consumption and risk of non-gallstone-related acute pancreatitis: a prospective cohort study. Am J Clin Nutr 2015; 101: 72-78
• 49 Phillip V, Huber W, Hagemes F. et al. Incidence of acute pancreatitis does not increase during Oktoberfest, but is higher than previously described in Germany. Clin Gastroenterol Hepatol 2011; 9: 995-1000.e1003
• 50 Lankisch PG, Karimi M, Bruns A. et al. Temporal trends in incidence and severity of acute pancreatitis in Lüneburg County, Germany: a population-based study. Pancreatology 2009; 9: 420-426
• 51 Yadav D, Timmons L, Benson JT. et al. Incidence, prevalence, and survival of chronic pancreatitis: a population-based study. Am J Gastroenterol 2011; 106: 2192-2199
• 52 Roberts SE, Morrison-Rees S, John A. et al. The incidence and aetiology of acute pancreatitis across Europe. Pancreatology 2017; 17: 155-165
• 53 Banks PA, Bollen TL, Dervenis C. et al. Classification of Acute pancreatitis-2012: Revision of the Atlanta Classification and Definitions by International Consensus. Gut 2013; 62: 102-111
• 54 [Anonym]. IAP/APA evidence-based guidelines for the management of acute pancreatitis. Pancreatology 2013; 13: e1-e15
• 55 Greenberg JA, Hsu J, Bawazeer M. et al. Clinical practice guideline: management of acute pancreatitis. Can J Surg 2016; 59: 128-140
• 56 Crockett SD, Wani S, Gardner TB. et al. American Gastroenterological Association Institute Guideline on Initial Management of Acute Pancreatitis. Gastroenterology 2018; 154: 1096-1101
• 57 Lankisch PG, Burchard-Reckert S, Lehnick D. Underestimation of acute pancreatitis: patients with only a small increase in amylase/lipase levels can also have or develop severe acute pancreatitis. Gut 1999; 44: 542-544
• 58 Wan J, Ouyang Y, Yu C. et al. Comparison of EUS with MRCP in idiopathic acute pancreatitis: a systematic review and meta-analysis. Gastrointest Endosc 2018; 87: 1180-1188.e1189
• 59 Banks PA, Bollen TL, Dervenis C. et al. Classification of acute pancreatitis--2012: revision of the Atlanta classification and definitions by international consensus. Gut 2013; 62: 102-111
• 60 Dellinger EP, Forsmark CE, Layer P. et al. Determinant-based classification of acute pancreatitis severity: an international multidisciplinary consultation. Ann Surg 2012; 256: 875-880
• 61 Marshall JC, Cook DJ, Christou NV. et al. Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome. Crit Care Med 1995; 23: 1638-1652
• 62 Vege SS, Gardner TB, Chari ST. et al. Low mortality and high morbidity in severe acute pancreatitis without organ failure: a case for revising the Atlanta classification to include “moderately severe acute pancreatitis”. Am J Gastroenterol 2009; 104: 710-715
• 63 Kadiyala V, Suleiman SL, McNabb-Baltar J. et al. The Atlanta Classification, Revised Atlanta Classification, and Determinant-Based Classification of Acute Pancreatitis: Which Is Best at Stratifying Outcomes?. Pancreas 2016; 45: 510-515
• 64 Bansal SS, Hodson J, Sutcliffe RS. et al. Performance of the revised Atlanta and determinant-based classifications for severity in acute pancreatitis. Br J Surg 2016; 103: 427-433
• 65 Lytras D, Manes K, Triantopoulou C. et al. Persistent early organ failure: defining the high-risk group of patients with severe acute pancreatitis?. Pancreas 2008; 36: 249-254
• 66 Guo Q, Li M, Chen Y. et al. Determinant-based classification and revision of the Atlanta classification, which one should we choose to categorize acute pancreatitis?. Pancreatology 2015; 15: 331-336
• 67 Choi JH, Kim MH, Oh D. et al. Clinical relevance of the revised Atlanta classification focusing on severity stratification system. Pancreatology 2014; 14: 324-329
• 68 Huang J, Qu HP, Zheng YF. et al. The revised Atlanta criteria 2012 altered the classification, severity assessment and management of acute pancreatitis. Hepatobiliary Pancreat Dis Int 2016; 15: 310-315
• 69 Bakker OJ, van Santvoort H, Besselink MG. et al. Extrapancreatic necrosis without pancreatic parenchymal necrosis: a separate entity in necrotising pancreatitis?. Gut 2013; 62: 1475-1480
• 70 Sternby H, Bolado F, Canaval-Zuleta HJ. et al. Determinants of Severity in Acute Pancreatitis: A Nation-wide Multicenter Prospective Cohort Study. Ann Surg 2019; 270: 348-355
• 71 Mikolasevic I, Milic S, Orlic L. et al. Metabolic syndrome and acute pancreatitis. Eur J Intern Med 2016; 32: 79-83
• 72 Natu A, Stevens T, Kang L. et al. Visceral Adiposity Predicts Severity of Acute Pancreatitis. Pancreas 2017; 46: 776-781
• 73 Papachristou GI, Papachristou DJ, Avula H. et al. Obesity increases the severity of acute pancreatitis: performance of APACHE-O score and correlation with the inflammatory response. Pancreatology 2006; 6: 279-285
• 74 Nawaz H, Koutroumpakis E, Easler J. et al. Elevated serum triglycerides are independently associated with persistent organ failure in acute pancreatitis. Am J Gastroenterol 2015; 110: 1497-1503
• 75 Lankisch PG, Assmus C, Pflichthofer D. et al. Which etiology causes the most severe acute pancreatitis?. Int J Pancreatol 1999; 26: 55-57
• 76 Chen HZ, Ji L, Li L. et al. Early prediction of infected pancreatic necrosis secondary to necrotizing pancreatitis. Medicine (Baltimore) 2017; 96: e7487
• 77 Wu BU, Bakker OJ, Papachristou GI. et al. Blood urea nitrogen in the early assessment of acute pancreatitis: an international validation study. Arch Intern Med 2011; 171: 669-676
• 78 Jin Z, Xu L, Wang X. et al. Risk Factors for Worsening of Acute Pancreatitis in Patients Admitted with Mild Acute Pancreatitis. Med Sci Monit 2017; 23: 1026-1032
• 79 Mounzer R, Langmead CJ, Wu BU. et al Comparison of existing clinical scoring systems to predict persistent organ failure in patients with acute pancreatitis. Gastroenterology 2012; 142: 1476-1482 ; quiz e1415-1476
• 80 Bone RC, Balk RA, Cerra FB. et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 1992; 101: 1644-1655
• 81 Kumar A, Chari ST, Vege SS. Can the time course of systemic inflammatory response syndrome score predict future organ failure in acute pancreatitis?. Pancreas 2014; 43: 1101-1105
• 82 Singh VK, Wu BU, Bollen TL. et al. Early systemic inflammatory response syndrome is associated with severe acute pancreatitis. Clin Gastroenterol Hepatol 2009; 7: 1247-1251
• 83 Mofidi R, Duff MD, Wigmore SJ. et al. Association between early systemic inflammatory response, severity of multiorgan dysfunction and death in acute pancreatitis. Br J Surg 2006; 93: 738-744
• 84 Bollen TL, Singh VK, Maurer R. et al. A comparative evaluation of radiologic and clinical scoring systems in the early prediction of severity in acute pancreatitis. Am J Gastroenterol 2012; 107: 612-619
• 85 Peng T, Peng X, Huang M. et al. Serum calcium as an indicator of persistent organ failure in acute pancreatitis. Am J Emerg Med 2017; 35: 978-982
• 86 Koutroumpakis E, Wu BU, Bakker OJ. et al. Admission Hematocrit and Rise in Blood Urea Nitrogen at 24h Outperform other Laboratory Markers in Predicting Persistent Organ Failure and Pancreatic Necrosis in Acute Pancreatitis: A Post Hoc Analysis of Three Large Prospective Databases. Am J Gastroenterol 2015; 110: 1707-1716
• 87 Cardoso FS, Ricardo LB, Oliveira AM. et al. C-reactive protein prognostic accuracy in acute pancreatitis: timing of measurement and cutoff points. Eur J Gastroenterol Hepatol 2013; 25: 784-789
• 88 Lankisch PG, Weber-Dany B, Hebel K. et al The harmless acute pancreatitis score: a clinical algorithm for rapid initial stratification of nonsevere disease. Clin Gastroenterol Hepatol 2009; 7: 702-705 ; quiz 607
• 89 Blamey SL, Imrie CW, O’Neill J. et al. Prognostic factors in acute pancreatitis. Gut 1984; 25: 1340-1346
• 90 Wu BU, Johannes RS, Sun X. et al. The early prediction of mortality in acute pancreatitis: a large population-based study. Gut 2008; 57: 1698-1703
• 91 Johnson CD, Abu-Hilal M. Persistent organ failure during the first week as a marker of fatal outcome in acute pancreatitis. Gut 2004; 53: 1340-1344
• 92 Acevedo-Piedra NG, Moya-Hoyo N, Rey-Riveiro M. et al. Validation of the determinant-based classification and revision of the Atlanta classification systems for acute pancreatitis. Clin Gastroenterol Hepatol 2014; 12: 311-316
• 93 Tee YS, Fang HY, Kuo IM. et al. Serial evaluation of the SOFA score is reliable for predicting mortality in acute severe pancreatitis. Medicine (Baltimore) 2018; 97: e9654
• 94 Wu BU, Batech M, Quezada M. et al. Dynamic Measurement of Disease Activity in Acute Pancreatitis: The Pancreatitis Activity Scoring System. Am J Gastroenterol 2017; 112: 1144-1152
• 95 Stirling AD, Moran NR, Kelly ME. et al. The predictive value of C-reactive protein (CRP) in acute pancreatitis – is interval change in CRP an additional indicator of severity?. HPB (Oxford) 2017; 19: 874-880
• 96 Lee KJ, Kim HM, Choi JS. et al. Comparison of Predictive Systems in Severe Acute Pancreatitis According to the Revised Atlanta Classification. Pancreas 2016; 45: 46-50
• 97 Modrau IS, Floyd AK, Thorlacius-Ussing O. The clinical value of procalcitonin in early assessment of acute pancreatitis. Am J Gastroenterol 2005; 100: 1593-1597
• 98 Rau BM, Kemppainen EA, Gumbs AA. et al. Early assessment of pancreatic infections and overall prognosis in severe acute pancreatitis by procalcitonin (PCT): a prospective international multicenter study. Ann Surg 2007; 245: 745-754
• 99 Levey AS, Levin A, Kellum JA. Definition and classification of kidney diseases. Am J Kidney Dis 2013; 61: 686-688
• 100 Lu Q, Zhong Y, Wen X-r. et al. Can contrast-enhanced ultrasound evaluate the severity of acute pancreatitis?. Dig Dis Sci 2011; 56: 1578-1584
• 101 Ripollés T, Martínez MJ, López E. et al. Contrast-enhanced ultrasound in the staging of acute pancreatitis. Eur Radiol 2010; 20: 2518-2523
• 102 Cai D-M, Parajuly SS, Ling W-W. et al. Diagnostic value of contrast enhanced ultrasound for splenic artery complications following acute pancreatitis. World J Gastroenterol 2014; 20: 1088-1094
• 103 Dörffel T, Wruck T, Rückert RI. et al. Vascular complications in acute pancreatitis assessed by color duplex ultrasonography. Pancreas 2000; 21: 126-133
• 104 Kamal A, Singh VK, Akshintala VS. et al. CT and MRI assessment of symptomatic organized pancreatic fluid collections and pancreatic duct disruption: an interreader variability study using the revised Atlanta classification 2012. Abdom Imaging 2015; 40: 1608-1616
• 105 López A, de la Cueva L, Martínez MJ. et al. Usefulness of technetium-99m hexamethylpropylene amine oxime-labeled leukocyte scintigraphy to detect pancreatic necrosis in patients with acute pancreatitis. Prospective comparison with Ranson, Glasgow and APACHE-II scores and serum C-reactive protein. Pancreatology 2007; 7: 470-478
• 106 Moreno-Osset E, López A, de la Cueva L. et al. 99mTc-hexamethylpropylene amineoxime leukocyte scintigraphy in acute pancreatitis: an alternative to contrast-enhanced computed tomography?. Am J Gastroenterol 2005; 100: 153-161
• 107 Bhattacharya A, Kochhar R, Sharma S. et al. PET/CT with 18F-FDG-labeled autologous leukocytes for the diagnosis of infected fluid collections in acute pancreatitis. J Nucl Med 2014; 55: 1267-1272
• 108 Smeets XJNM, Litjens G, Gijsbers K. et al. The Accuracy of Pancreatic Perfusion Computed Tomography and Angiography in Predicting Necrotizing Pancreatitis: A Systematic Review. Pancreas 2018; 47: 667-674
• 109 Munoz-Bongrand N, Panis Y, Soyer P. et al. Serial computed tomography is rarely necessary in patients with acute pancreatitis: a prospective study in 102 patients. J Am Coll Surg 2001; 193: 146-152
• 110 Dobbs NW, Budak MJ, Weir-McCall JR. et al. Acute pancreatitis: a comparison of intervention rates precipitated by early vs guideline CT scan timing. Clin Radiol 2016; 71: 993-996
• 111 Dachs RJ, Sullivan L, Shanmugathasan P. Does early ED CT scanning of afebrile patients with first episodes of acute pancreatitis ever change management?. Emerg Radiol 2015; 22: 239-243
• 112 Rehan A, Shabbir Z, Shaukat A. et al. Diagnostic Accuracy of Modified CT Severity Index in Assessing Severity of Acute Pancreatitis. J Coll Physicians Surg Pak 2016; 26: 967-970
• 113 Bollen TL, Singh VK, Maurer R. et al. A comparative evaluation of radiologic and clinical scoring systems in the early prediction of severity in acute pancreatitis. Am J Gastroenterol 2012; 107: 612-619
• 114 Meyrignac O, Lagarde S, Bournet B. et al. Acute Pancreatitis: Extrapancreatic Necrosis Volume as Early Predictor of Severity. Radiology 2015; 276: 119-128
• 115 Stimac D, Miletić D, Radić M. et al. The role of nonenhanced magnetic resonance imaging in the early assessment of acute pancreatitis. Am J Gastroenterol 2007; 102: 997-1004
• 116 Arvanitakis M, Koustiani G, Gantzarou A. et al. Staging of severity and prognosis of acute pancreatitis by computed tomography and magnetic resonance imaging-a comparative study. Dig Liver Dis 2007; 39: 473-482
• 117 de Freitas Tertulino F, Schraibman V, Ardengh JC. et al. Diffusion-weighted magnetic resonance imaging indicates the severity of acute pancreatitis. Abdom Imaging 2015; 40: 265-271
• 118 Fukukura Y, Takumi K, Kamiyama T. et al. Pancreatic adenocarcinoma: a comparison of automatic bolus tracking and empirical scan delay. Abdom Imaging 2010; 35: 548-555
• 119 Kondo H, Kanematsu M, Goshima S. et al. MDCT of the pancreas: optimizing scanning delay with a bolus-tracking technique for pancreatic, peripancreatic vascular, and hepatic contrast enhancement. Am J Roentgenol 2007; 188: 751-756
• 120 Hollett MD, Jorgensen MJ, Jeffrey RB. et al. Quantitative evaluation of pancreatic enhancement during dual-phase helical CT. Radiology 1995; 195: 359-361
• 121 Kwon Y, Park HS, Kim YJ. et al. Multidetector row computed tomography of acute pancreatitis: Utility of single portal phase CT scan in short-term follow up. Eur J Radiol 2012; 81: 1728-1734
• 122 Hyare H, Desigan S, Nicholl H. et al. Multi-section CT angiography compared with digital subtraction angiography in diagnosing major arterial hemorrhage in inflammatory pancreatic disease. Eur J Radiol 2006; 59: 295-300
• 123 Paparo F, Garello I, Bacigalupo L. et al. CT of the abdomen: Degree and quality of enhancement obtained with two concentrations of the same iodinated contrast medium with fixed iodine delivery rate and total iodine load. European Journal of Radiology 2014; 83: 1995-2000
• 124 Gocke P, Gocke C, Neumann K. et al. Prospective randomized study for an injection protocol for intravenous contrast media in abdominal and pelvic helical CT. Acta Radiol 1999; 40: 515-520
• 125 Yanaga Y, Awai K, Nakayama Y. et al. Pancreas: Patient Body Weight–tailored Contrast Material Injection Protocol versus Fixed Dose Protocol at Dynamic CT. Radiology 2007; 245: 475-482
• 126 McDonald RJ, McDonald JS, Carter RE. et al. Intravenous contrast material exposure is not an independent risk factor for dialysis or mortality. Radiology 2014; 273: 714-725
• 127 Aycock RD, Westafer LM, Boxen JL. et al. Acute Kidney Injury After Computed Tomography: A Meta-analysis. Ann Emerg Med 2018; 71: 44-53 e44
• 128 Wilhelm-Leen E, Montez-Rath ME, Chertow G. Estimating the Risk of Radiocontrast-Associated Nephropathy. J Am Soc Nephrol 2017; 28: 653-659
• 129 Thevenot A, Bournet B, Otal P. et al. Endoscopic ultrasound and magnetic resonance cholangiopancreatography in patients with idiopathic acute pancreatitis. Dig Dis Sci 2013; 58: 2361-2368
• 130 Buxbaum J, Yan A, Yeh K. et al. Aggressive hydration with lactated Ringer’s solution reduces pancreatitis after endoscopic retrograde cholangiopancreatography. Clin Gastroenterol Hepatol 2014; 12: 303-307 e301
• 131 Mao EQ, Fei J, Peng YB. et al. Rapid hemodilution is associated with increased sepsis and mortality among patients with severe acute pancreatitis. Chin Med J (Engl) 2010; 123: 1639-1644
• 132 Mao EQ, Tang YQ, Fei J. et al. Fluid therapy for severe acute pancreatitis in acute response stage. Chin Med J (Engl) 2009; 122: 169-173
• 133 Wang MD, Ji Y, Xu J. et al. Early goal-directed fluid therapy with fresh frozen plasma reduces severe acute pancreatitis mortality in the intensive care unit. Chin Med J (Engl) 2013; 126: 1987-1988
• 134 Wu BU, Hwang JQ, Gardner TH. et al. Lactated Ringer’s solution reduces systemic inflammation compared with saline in patients with acute pancreatitis. Clin Gastroenterol Hepatol 2011; 9: 710-717 e711
• 135 Brown A, Orav J, Banks PA. Hemoconcentration is an early marker for organ failure and necrotizing pancreatitis. Pancreas 2000; 20: 367-372
• 136 Gardner TB, Vege SS, Chari ST. et al. Faster rate of initial fluid resuscitation in severe acute pancreatitis diminishes in-hospital mortality. Pancreatology 2009; 9: 770-776
• 137 Lankisch PG, Mahlke R, Blum T. et al. Hemoconcentration: an early marker of severe and/or necrotizing pancreatitis? A critical appraisal. Am J Gastroenterol 2001; 96: 2081-2085
• 138 Mole DJ, Hall A, McKeown D. et al. Detailed fluid resuscitation profiles in patients with severe acute pancreatitis. HPB (Oxford) 2011; 13: 51-58
• 139 Sun Y, Lu ZH, Zhang XS. et al. The effects of fluid resuscitation according to PiCCO on the early stage of severe acute pancreatitis. Pancreatology 2015;
• 140 Warndorf MG, Kurtzman JT, Bartel MJ. et al. Early fluid resuscitation reduces morbidity among patients with acute pancreatitis. Clin Gastroenterol Hepatol 2011; 9: 705-709
• 141 Wall I, Badalov N, Baradarian R. et al. Decreased mortality in acute pancreatitis related to early aggressive hydration. Pancreas 2011; 40: 547-550
• 142 Huber W, Phillip V, Schmid R. et al. Acute Pancreatitis: What is new?. Dtsch Med Wochenschr 2017; 142: 525-529
• 143 Yamashita T, Horibe M, Sanui M. et al. Large Volume Fluid Resuscitation for Severe Acute Pancreatitis is Associated With Reduced Mortality: A Multicenter Retrospective Study. J Clin Gastroenterol 2019; 53: 385-391
• 144 Huber W, Schneider J, Schmid RM. Therapie der schweren akuten Pankreatitis. Der Gastroenterologe 2020; 15: 41-52
• 145 Huber W, Umgelter A, Reindl W. et al. Volume assessment in patients with necrotizing pancreatitis: a comparison of intrathoracic blood volume index, central venous pressure, and hematocrit, and their correlation to cardiac index and extravascular lung water index. Crit Care Med 2008; 36: 2348-2354
• 146 Wu BU, Johannes RS, Conwell DL. et al. Early hemoconcentration predicts increased mortality only among transferred patients with acute pancreatitis. Pancreatology 2009; 9: 639-643
• 147 Wu BU, Johannes RS, Sun X. et al. Early changes in blood urea nitrogen predict mortality in acute pancreatitis. Gastroenterology 2009; 137: 129-135
• 148 Marik PE, Cavallazzi R. Does the central venous pressure predict fluid responsiveness? An updated meta-analysis and a plea for some common sense. Crit Care Med 2013; 41: 1774-1781
• 149 Trepte CJ, Bachmann KA, Stork JH. et al. The impact of early goal-directed fluid management on survival in an experimental model of severe acute pancreatitis. Intensive Care Med 2013; 39: 717-726
• 150 Iqbal U, Anwar H, Scribani M. Ringer’s lactate versus normal saline in acute pancreatitis: A systematic review and meta-analysis. J Dig Dis 2018; 19: 335-341
• 151 Basurto Ona X, Rigau Comas D, Urrutia G. Opioids for acute pancreatitis pain. Cochrane Database Syst Rev 2013; CD009179
• 152 Meng W, Yuan J, Zhang C. et al. Parenteral analgesics for pain relief in acute pancreatitis: a systematic review. Pancreatology 2013; 13: 201-206
• 153 Kahl S, Zimmermann S, Pross M. et al. Procaine hydrochloride fails to relieve pain in patients with acute pancreatitis. Digestion 2004; 69: 5-9
• 154 Bernhardt A, Kortgen A, Niesel H. et al. [Using epidural anesthesia in patients with acute pancreatitis--prospective study of 121 patients]. Anaesthesiologie und Reanimation 2002; 27: 16-22
• 155 Jabaudon M, Belhadj-Tahar N, Rimmele T. et al. Thoracic Epidural Analgesia and Mortality in Acute Pancreatitis: A Multicenter Propensity Analysis. Crit Care Med 2018; 46: e198-e205
• 156 Kirkpatrick AW, Roberts DJ, De Waele J. et al. Intra-abdominal hypertension and the abdominal compartment syndrome: updated consensus definitions and clinical practice guidelines from the World Society of the Abdominal Compartment Syndrome. Intensive Care Med 2013; 39: 1190-1206
• 157 Kirkpatrick AW, Sugrue M, McKee JL. et al. Update from the Abdominal Compartment Society (WSACS) on intra-abdominal hypertension and abdominal compartment syndrome: past, present, and future beyond Banff 2017. Anaesthesiol Intensive Ther 2017; 49: 83-87
• 158 Ranson JH, Rifkind KM, Roses DF. et al. Prognostic signs and the role of operative management in acute pancreatitis. Surg Gynecol Obstet 1974; 139: 69-81
• 159 Flint R, Windsor JA. Early physiological response to intensive care as a clinically relevant approach to predicting the outcome in severe acute pancreatitis. Arch Surg 2004; 139: 438-443
• 160 Shen HN, Lu CL, Li CY. The effect of hospital volume on patient outcomes in severe acute pancreatitis. BMC Gastroenterol 2012; 12: 112
• 161 Singla A, Simons J, Li Y. et al. Admission volume determines outcome for patients with acute pancreatitis. Gastroenterology 2009; 137: 1995-2001
• 162 Krautz C, Nimptsch U, Weber GF. et al. Effect of Hospital Volume on In-hospital Morbidity and Mortality Following Pancreatic Surgery in Germany. Ann Surg 2018; 267: 411-417
• 163 Baltatzis M, Mason JM, Chandrabalan V. et al. Antibiotic use in acute pancreatitis: An audit of current practice in a tertiary centre. Pancreatology 2016; 16: 946-951
• 164 Talukdar R, Ingale P, Choudhury HP. et al. Antibiotic use in acute pancreatitis: an Indian multicenter observational study. Indian J Gastroenterol 2014; 33: 458-465
• 165 Howes R, Zuidema GD, Cameron JL. Evaluation of prophylactic antibiotics in acute pancreatitis. J Surg Res 1975; 18: 197-200
• 166 Finch WT, Sawyers JL, Schenker S. A prospective study to determine the efficacy of antibiotics in acute pancreatitis. Ann Surg 1976; 183: 667-671
• 167 Golub R, Siddiqi F, Pohl D. Role of antibiotics in acute pancreatitis: A meta-analysis. J Gastrointest Surg 1998; 2: 496-503
• 168 Ukai T, Shikata S, Inoue M. et al. Early prophylactic antibiotics administration for acute necrotizing pancreatitis: a meta-analysis of randomized controlled trials. J Hepatobiliary Pancreat Sci 2015; 22: 316-321
• 169 Luiten EJ, Hop WC, Lange JF. et al. Differential prognosis of gram-negative versus gram-positive infected and sterile pancreatic necrosis: results of a randomized trial in patients with severe acute pancreatitis treated with adjuvant selective decontamination. Clin Infect Dis 1997; 25: 811-816
• 170 Ding N, Sun YH, Wen LM. et al. Assessment of prophylactic antibiotics administration for acute pancreatitis: a meta-analysis of randomized controlled trials. Chin Med J (Engl) 2020; 133: 212-220
• 171 Garg PK, Khanna S, Bohidar NP. et al. Incidence, spectrum and antibiotic sensitivity pattern of bacterial infections among patients with acute pancreatitis. J Gastroenterol Hepatol 2001; 16: 1055-1059
• 172 Luiten EJ, Hop WC, Lange JF. et al. Controlled clinical trial of selective decontamination for the treatment of severe acute pancreatitis. Ann Surg 1995; 222: 57-65
• 173 Leppaniemi A, Tolonen M, Tarasconi A. et al. 2019 WSES guidelines for the management of severe acute pancreatitis. World J Emerg Surg 2019; 14: 27
• 174 Villatoro E, Mulla M, Larvin M. Antibiotic therapy for prophylaxis against infection of pancreatic necrosis in acute pancreatitis. Cochrane Database Syst Rev 2010; CD002941
• 175 Wittau M, Hohl K, Mayer J. et al. The weak evidence base for antibiotic prophylaxis in severe acute pancreatitis. Hepatogastroenterology 2008; 55: 2233-2237
• 176 Besselink MG, van Santvoort HC, Buskens E. et al. Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial. Lancet (London, England) 2008; 371: 651-659
• 177 [Anonym]. Expression of concern-Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial. Lancet (London, England) 2010; 375: 875-876
• 178 Dikkenberg GM. Probiotic prophylaxis in patients with predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial and informed consent procedure. Ned Tijdschr Geneeskd 2008; 152: 1592 ; author reply 1592-1594
• 179 Bongaerts GP, Severijnen RS. A reassessment of the PROPATRIA study and its implications for probiotic therapy. Nat Biotechnol 2016; 34: 55-63
• 180 Hooijmans CR, de Vries RB, Rovers MM. et al. The effects of probiotic supplementation on experimental acute pancreatitis: a systematic review and meta-analysis. PLoS One 2012; 7: e48811
• 181 Gou S, Yang Z, Liu T. et al. Use of probiotics in the treatment of severe acute pancreatitis: a systematic review and meta-analysis of randomized controlled trials. Crit Care 2014; 18: R57
• 182 Zhang MM, Cheng JQ, Lu YR. et al. Use of pre-, pro- and synbiotics in patients with acute pancreatitis: a meta-analysis. World J Gastroenterol 2010; 16: 3970-3978
• 183 van Baal MC, Kohout P, Besselink MG. et al. Probiotic treatment with Probioflora in patients with predicted severe acute pancreatitis without organ failure. Pancreatology 2012; 12: 458-462
• 184 Plaudis H, Pupelis G, Zeiza K. et al. Early low volume oral synbiotic/prebiotic supplemented enteral stimulation of the gut in patients with severe acute pancreatitis: a prospective feasibility study. Acta Chir Belg 2012; 112: 131-138
• 185 Besselink MG, van Santvoort HC, Renooij W. et al. Intestinal barrier dysfunction in a randomized trial of a specific probiotic composition in acute pancreatitis. Ann Surg 2009; 250: 712-719
• 186 Bakker OJ, van Brunschot S, Farre A. et al. Timing of enteral nutrition in acute pancreatitis: meta-analysis of individuals using a single-arm of randomised trials. Pancreatology 2014; 14: 340-346
• 187 Eckerwall GE, Tingstedt BB, Bergenzaun PE. et al. Immediate oral feeding in patients with mild acute pancreatitis is safe and may accelerate recovery--a randomized clinical study. Clin Nutr 2007; 26: 758-763
• 188 Larino-Noia J, Lindkvist B, Iglesias-Garcia J. et al. Early and/or immediately full caloric diet versus standard refeeding in mild acute pancreatitis: a randomized open-label trial. Pancreatology 2014; 14: 167-173
• 189 Li J, Xue GJ, Liu YL. et al. Early oral refeeding wisdom in patients with mild acute pancreatitis. Pancreas 2013; 42: 88-91
• 190 Ren T, Shi Z, Tang J. et al. Risk factors of refeeding intolerance in mild acute interstitial pancreatitis: a retrospective study of 323 patients. Pancreatology 2015; 15: 111-114
• 191 Marik PE, Zaloga GP. Meta-analysis of parenteral nutrition versus enteral nutrition in patients with acute pancreatitis. BMJ 2004; 328: 1407
• 192 Pagliari D, Rinninella E, Cianci R. et al. Early oral vs parenteral nutrition in acute pancreatitis: a retrospective analysis of clinical outcomes and hospital costs from a tertiary care referral center. Intern Emerg Med 2019;
• 193 Gupta R, Patel K, Calder PC. et al. A randomised clinical trial to assess the effect of total enteral and total parenteral nutritional support on metabolic, inflammatory and oxidative markers in patients with predicted severe acute pancreatitis (APACHE II > or =6). Pancreatology 2003; 3: 406-413
• 194 Petrov MS, Kukosh MV, Emelyanov NV. A randomized controlled trial of enteral versus parenteral feeding in patients with predicted severe acute pancreatitis shows a significant reduction in mortality and in infected pancreatic complications with total enteral nutrition. Dig Surg 2006; 23: 336-344 ; discussion 344-335
• 195 Windsor AC, Kanwar S, Li AG. et al. Compared with parenteral nutrition, enteral feeding attenuates the acute phase response and improves disease severity in acute pancreatitis. Gut 1998; 42: 431-435
• 196 Bakker OJ, van Brunschot S, van Santvoort HC. et al. Early versus on-demand nasoenteric tube feeding in acute pancreatitis. N Engl J Med 2014; 371: 1983-1993
• 197 Li JY, Yu T, Chen GC. et al. Enteral nutrition within 48 hours of admission improves clinical outcomes of acute pancreatitis by reducing complications: a meta-analysis. PLoS One 2013; 8: e64926
• 198 Wereszczynska-Siemiatkowska U, Swidnicka-Siergiejko A, Siemiatkowski A. et al. Early enteral nutrition is superior to delayed enteral nutrition for the prevention of infected necrosis and mortality in acute pancreatitis. Pancreas 2013; 42: 640-646
• 199 Zhao XL, Zhu SF, Xue GJ. et al. Early oral refeeding based on hunger in moderate and severe acute pancreatitis: a prospective controlled, randomized clinical trial. Nutrition 2015; 31: 171-175
• 200 Austrums E, Pupelis G, Snippe K. Postoperative enteral stimulation by gut feeding improves outcomes in severe acute pancreatitis. Nutrition 2003; 19: 487-491
• 201 Shi D, Zhang CW, Jiang JS. et al. Enteral nutrition in treatment of severe acute pancreatitis. Hepatobiliary Pancreat Dis Int 2002; 1: 146-149
• 202 Sun JK, Mu XW, Li WQ. et al. Effects of early enteral nutrition on immune function of severe acute pancreatitis patients. World J Gastroenterol 2013; 19: 917-922
• 203 Evennett NJ, Petrov MS, Mittal A. et al. Systematic review and pooled estimates for the diagnostic accuracy of serological markers for intestinal ischemia. World J Surg 2009; 33: 1374-1383
• 204 Ockenga J, Löser C, Kraft M. et al. S3-Leitlinie der Deutschen Gesellschaft für Ernährungsmedizin (DGEM) in Zusammenarbeit mit der GESKES, der AKE und der DGVS, Klinische Ernährung in der Gastroenterologie (Teil 2) – Pankreas. Aktuel Ernahrungsmed 2014; 39: e43-e56
• 205 Eatock FC, Chong P, Menezes N. et al. A randomized study of early nasogastric versus nasojejunal feeding in severe acute pancreatitis. Am J Gastroenterol 2005; 100: 432-439
• 206 Kumar A, Singh N, Prakash S. et al. Early enteral nutrition in severe acute pancreatitis: a prospective randomized controlled trial comparing nasojejunal and nasogastric routes. J Clin Gastroenterol 2006; 40: 431-434
• 207 Singh N, Sharma B, Sharma M. et al. Evaluation of early enteral feeding through nasogastric and nasojejunal tube in severe acute pancreatitis: a noninferiority randomized controlled trial. Pancreas 2012; 41: 153-159
• 208 Nally DM, Kelly EG, Clarke M. et al. Nasogastric nutrition is efficacious in severe acute pancreatitis: a systematic review and meta-analysis. Br J Nutr 2014; 112: 1769-1778
• 209 Petrov MS, Correia MI, Windsor JA. Nasogastric tube feeding in predicted severe acute pancreatitis. A systematic review of the literature to determine safety and tolerance. JOP 2008; 9: 440-448
• 210 Seminerio J, O’Keefe SJ. Jejunal feeding in patients with pancreatitis. Nutr Clin Pract 2014; 29: 283-286
• 211 Stimac D, Poropat G, Hauser G. et al. Early nasojejunal tube feeding versus nil-by-mouth in acute pancreatitis: A randomized clinical trial. Pancreatology 2016; 16: 523-528
• 212 Venneman NG, Buskens E, Besselink MG. et al. Small gallstones are associated with increased risk of acute pancreatitis: potential benefits of prophylactic cholecystectomy?. Am J Gastroenterol 2005; 100: 2540-2550
• 213 van Santvoort HC, Bakker OJ, Besselink MG. et al. Prediction of common bile duct stones in the earliest stages of acute biliary pancreatitis. Endoscopy 2011; 43: 8-13
• 214 Tenner S, Dubner H, Steinberg W. Predicting gallstone pancreatitis with laboratory parameters: a meta-analysis. Am J Gastroenterol 1994; 89: 1863-1866
• 215 Ammori BJ, Boreham B, Lewis P. et al. The biochemical detection of biliary etiology of acute pancreatitis on admission: a revisit in the modern era of biliary imaging. Pancreas 2003; 26: e32-e35
• 216 Mayer AD, McMahon MJ. Biochemical identification of patients with gallstones associated with acute pancreatitis on the day of admission to hospital. Ann Surg 1985; 201: 68-75
• 217 Kiriyama S, Kozaka K, Takada T. et al. Tokyo Guidelines 2018: diagnostic criteria and severity grading of acute cholangitis (with videos). J Hepatobiliary Pancreat Sci 2018; 25: 17-30
• 218 Sun G, Han L, Yang YS. et al. Verification of the Tokyo guidelines for acute cholangitis secondary to benign and malignant biliary obstruction: experience from a Chinese tertiary hospital. Hepatobiliary Pancreat Dis Int 2013; 12: 400-407
• 219 Miura F, Okamoto K, Takada T. et al. Tokyo Guidelines 2018: initial management of acute biliary infection and flowchart for acute cholangitis. J Hepatobiliary Pancreat Sci 2018; 25: 31-40
• 220 Alper E, Unsal B, Buyrac Z. et al. Role of radial endosonography in the diagnosis of acute cholangitis. Dig Dis Sci 2011; 56: 2191-2196
• 221 Eun HW, Kim JH, Hong SS. et al. Assessment of acute cholangitis by MR imaging. Eur J Radiol 2012; 81: 2476-2480
• 222 Arai K, Kawai K, Kohda W. et al. Dynamic CT of acute cholangitis: early inhomogeneous enhancement of the liver. Am J Roentgenol 2003; 181: 115-118
• 223 Balthazar EJ, Birnbaum BA, Naidich M. Acute cholangitis: CT evaluation. J Comput Assist Tomogr 1993; 17: 283-289
• 224 Kim SW, Shin HC, Kim HC. et al. Diagnostic performance of multidetector CT for acute cholangitis: evaluation of a CT scoring method. Br J Radiol 2012; 85: 770-777
• 225 Tse F, Yuan Y. Early routine endoscopic retrograde cholangiopancreatography strategy versus early conservative management strategy in acute gallstone pancreatitis. Cochrane Database Syst Rev 2012; CD009779
• 226 van Santvoort HC, Besselink MG, de Vries AC. et al. Early endoscopic retrograde cholangiopancreatography in predicted severe acute biliary pancreatitis: a prospective multicenter study. Ann Surg 2009; 250: 68-75
• 227 Folsch UR, Nitsche R, Ludtke R. et al. Early ERCP and papillotomy compared with conservative treatment for acute biliary pancreatitis. The German Study Group on Acute Biliary Pancreatitis. N Engl J Med 1997; 336: 237-242
• 228 Besselink MG, van Minnen LP, van Erpecum KJ. et al. Beneficial effects of ERCP and papillotomy in predicted severe biliary pancreatitis. Hepatogastroenterology 2005; 52: 37-39
• 229 Burstow MJ, Yunus RM, Hossain MB. et al. Meta-Analysis of Early Endoscopic Retrograde Cholangiopancreatography (ERCP) +/- Endoscopic Sphincterotomy (ES) Versus Conservative Management for Gallstone Pancreatitis (GSP). Surg Laparosc Endosc Percutan Tech 2015; 25: 185-203
• 230 Sharma VK, Howden CW. Metaanalysis of randomized controlled trials of endoscopic retrograde cholangiography and endoscopic sphincterotomy for the treatment of acute biliary pancreatitis. Am J Gastroenterol 1999; 94: 3211-3214
• 231 Schepers NJ, Hallensleben NDL, Besselink MG. et al. Urgent endoscopic retrograde cholangiopancreatography with sphincterotomy versus conservative treatment in predicted severe acute gallstone pancreatitis (APEC): a multicentre randomised controlled trial. Lancet (London, England) 2020; 396: 167-176
• 232 van Geenen EJ, van Santvoort HC, Besselink MG. et al. Lack of consensus on the role of endoscopic retrograde cholangiography in acute biliary pancreatitis in published meta-analyses and guidelines: a systematic review. Pancreas 2013; 42: 774-780
• 233 Rickes S, Treiber G, Monkemuller K. et al. Impact of the operator’s experience on value of high-resolution transabdominal ultrasound in the diagnosis of choledocholithiasis: a prospective comparison using endoscopic retrograde cholangiography as the gold standard. Scand J Gastroenterol 2006; 41: 838-843
• 234 Gurusamy KS, Giljaca V, Takwoingi Y. et al. Ultrasound versus liver function tests for diagnosis of common bile duct stones. Cochrane Database Syst Rev 2015; CD011548
• 235 Lee SL, Kim HK, Choi HH. et al. Diagnostic value of magnetic resonance cholangiopancreatography to detect bile duct stones in acute biliary pancreatitis. Pancreatology 2018; 18: 22-28
• 236 Liu CL, Lo CM, Chan JK. et al. Detection of choledocholithiasis by EUS in acute pancreatitis: a prospective evaluation in 100 consecutive patients. Gastrointest Endosc 2001; 54: 325-330
• 237 Kondo S, Isayama H, Akahane M. et al. Detection of common bile duct stones: comparison between endoscopic ultrasonography, magnetic resonance cholangiography, and helical-computed-tomographic cholangiography. Eur J Radiol 2005; 54: 271-275
• 238 Banks PA, Freeman ML. Practice Parameters Committee of the American College of G. Practice guidelines in acute pancreatitis. Am J Gastroenterol 2006; 101: 2379-2400
• 239 Working Party of the British Society of G, Association of Surgeons of Great B, Ireland. et al. UK guidelines for the management of acute pancreatitis. Gut 2005; 54 (Suppl. 03) iii1-iii9
• 240 Trna J, Vege SS, Pribramska V. et al. Lack of significant liver enzyme elevation and gallstones and/or sludge on ultrasound on day 1 of acute pancreatitis is associated with recurrence after cholecystectomy: a population-based study. Surgery 2012; 151: 199-205
• 241 van Baal MC, Besselink MG, Bakker OJ. et al. Timing of cholecystectomy after mild biliary pancreatitis: a systematic review. Ann Surg 2012; 255: 860-866
• 242 Aboulian A, Chan T, Yaghoubian A. et al. Early cholecystectomy safely decreases hospital stay in patients with mild gallstone pancreatitis: a randomized prospective study. Ann Surg 2010; 251: 615-619
• 243 da Costa DW, Bouwense SA, Schepers NJ. et al. Same-admission versus interval cholecystectomy for mild gallstone pancreatitis (PONCHO): a multicentre randomised controlled trial. Lancet 2015; 386: 1261-1268
• 244 Uomo G, Manes G, Laccetti M. et al. Endoscopic sphincterotomy and recurrence of acute pancreatitis in gallstone patients considered unfit for surgery. Pancreas 1997; 14: 28-31
• 245 Vazquez-Lglesias JL, Gonzalez-Conde B, Lopez-Roses L. et al. Endoscopic sphincterotomy for prevention of the recurrence of acute biliary pancreatitis in patients with gallbladder in situ: long-term follow-up of 88 patients. Surg Endosc 2004; 18: 1442-1446
• 246 Hammarstrom LE, Stridbeck H, Ihse I. Effect of endoscopic sphincterotomy and interval cholecystectomy on late outcome after gallstone pancreatitis. Br J Surg 1998; 85: 333-336
• 247 Teoh AY, Poon MC, Leong HT. Role of prophylactic endoscopic sphincterotomy in patients with acute biliary pancreatitis due to transient common bile duct obstruction. J Gastroenterol Hepatol 2007; 22: 1415-1418
• 248 Islim F, Salik AE, Bayramoglu S. et al. Non-invasive detection of infection in acute pancreatic and acute necrotic collections with diffusion-weighted magnetic resonance imaging: preliminary findings. Abdom Imaging 2014; 39: 472-481
• 249 Finkelmeier F, Sturm C, Friedrich-Rust M. et al. Predictive Value of Computed Tomography Scans and Clinical Findings for the Need of Endoscopic Necrosectomy in Walled-off Necrosis From Pancreatitis. Pancreas 2017; 46: 1039-1045
• 250 Paye F, Rotman N, Radier C. et al. Percutaneous aspiration for bacteriological studies in patients with necrotizing pancreatitis. Br J Surg 1998; 85: 755-759
• 251 Rau B, Pralle U, Mayer JM. et al. Role of ultrasonographically guided fine-needle aspiration cytology in the diagnosis of infected pancreatic necrosis. Br J Surg 1998; 85: 179-184
• 252 Stiles GM, Berne TV, Thommen VD. et al. Fine needle aspiration of pancreatic fluid collections. Am Surg 1990; 56: 764-768
• 253 van Baal MC, Bollen TL, Bakker OJ. et al. The role of routine fine-needle aspiration in the diagnosis of infected necrotizing pancreatitis. Surgery 2014; 155: 442-448
• 254 Sharma VK, Howden CW. Prophylactic antibiotic administration reduces sepsis and mortality in acute necrotizing pancreatitis: a meta-analysis. Pancreas 2001; 22: 28-31
• 255 Isenmann R, Rünzi M, Kron M. et al. Prophylactic antibiotic treatment in patients with predicted severe acute pancreatitis: a placebo-controlled, double-blind trial. Gastroenterology 2004; 126: 997-1004
• 256 Dellinger EP, Tellado JM, Soto NE. et al. Early antibiotic treatment for severe acute necrotizing pancreatitis: a randomized, double-blind, placebo-controlled study. Ann Surg 2007; 245: 674-683
• 257 García-Barrasa A, Borobia FG, Pallares R. et al. A double-blind, placebo-controlled trial of ciprofloxacin prophylaxis in patients with acute necrotizing pancreatitis. J Gastrointest Surg 2009; 13: 768-774
• 258 Sarathi Patra P, Das K, Bhattacharyya A. et al. Natural resolution or intervention for fluid collections in acute severe pancreatitis. Br J Surg 2014; 101: 1721-1728
• 259 Schwender BJ, Gordon SR, Gardner TB. Risk factors for the development of intra-abdominal fungal infections in acute pancreatitis. Pancreas 2015; 44: 805-807
• 260 Kochhar R, Ahammed SK, Chakrabarti A. et al. Prevalence and outcome of fungal infection in patients with severe acute pancreatitis. J Gastroenterol Hepatol 2009; 24: 743-747
• 261 Besselink MG, van Santvoort HC, Boermeester MA. et al. Timing and impact of infections in acute pancreatitis. Br J Surg 2009; 96: 267-273
• 262 Mier J, León EL, Castillo A. et al. Early versus late necrosectomy in severe necrotizing pancreatitis. Am J Surg 1997; 173: 71-75
• 263 Rau BM, Bothe A, Kron M. et al. Role of early multisystem organ failure as major risk factor for pancreatic infections and death in severe acute pancreatitis. Clin Gastroenterol Hepatol 2006; 4: 1053-1061
• 264 Werge M, Novovic S, Schmidt PN. et al. Infection increases mortality in necrotizing pancreatitis: A systematic review and meta-analysis. Pancreatology 2016; 16: 698-707
• 265 Ji L, Wang G, Li L. et al. Risk Factors for the Need of Surgical Necrosectomy After Percutaneous Catheter Drainage in the Management of Infection Secondary to Necrotizing Pancreatitis. Pancreas 2018; 47: 436-443
• 266 Besselink MG, Verwer TJ, Schoenmaeckers EJ. et al. Timing of surgical intervention in necrotizing pancreatitis. Arch Surg 2007; 142: 1194-1201
• 267 Dong X, Gao SL, Xie QP. et al. In situ high-volume modified continuous closed and/or open lavage for infected necrotizing pancreatitis. Pancreas 2008; 36: 44-49
• 268 Seifert H, Biermer M, Schmitt W. et al. Transluminal endoscopic necrosectomy after acute pancreatitis: a multicentre study with long-term follow-up (the GEPARD Study). Gut 2009; 58: 1260-1266
• 269 Gardner TB, Chahal P, Papachristou GI. et al. A comparison of direct endoscopic necrosectomy with transmural endoscopic drainage for the treatment of walled-off pancreatic necrosis. Gastrointest Endosc 2009; 69: 1085-1094
• 270 Bang JY, Holt BA, Hawes RH. et al. Outcomes after implementing a tailored endoscopic step-up approach to walled-off necrosis in acute pancreatitis. Br J Surg 2014; 101: 1729-1738
• 271 Kumar N, Conwell DL, Thompson CC. Direct endoscopic necrosectomy versus step-up approach for walled-off pancreatic necrosis: comparison of clinical outcome and health care utilization. Pancreas 2014; 43: 1334-1339
• 272 Abdelhafez M, Elnegouly M, Hasab Allah MS. et al. Transluminal retroperitoneal endoscopic necrosectomy with the use of hydrogen peroxide and without external irrigation: a novel approach for the treatment of walled-off pancreatic necrosis. Surg Endosc 2013; 27: 3911-3920
• 273 Bang JY, Arnoletti JP, Holt BA. et al. An Endoscopic Transluminal Approach, Compared With Minimally Invasive Surgery, Reduces Complications and Costs for Patients With Necrotizing Pancreatitis. Gastroenterology 2019; 156: 1027-1040.e1023
• 274 van Brunschot S, van Grinsven J, van Santvoort HC. et al. Endoscopic or surgical step-up approach for infected necrotising pancreatitis: a multicentre randomised trial. Lancet (London, England) 2018; 391: 51-58
• 275 Gluck M, Ross A, Irani S. et al. Endoscopic and percutaneous drainage of symptomatic walled-off pancreatic necrosis reduces hospital stay and radiographic resources. Clin Gastroenterol Hepatol 2010; 8: 1083-1088
• 276 Bakker OJ, van Santvoort HC, van Brunschot S. et al. Endoscopic transgastric vs surgical necrosectomy for infected necrotizing pancreatitis: a randomized trial. Jama 2012; 307: 1053-1061
• 277 van Brunschot S, Hollemans RA, Bakker OJ. et al. Minimally invasive and endoscopic versus open necrosectomy for necrotising pancreatitis: a pooled analysis of individual data for 1980 patients. Gut 2018; 67: 697-706
• 278 Bausch D, Wellner U, Kahl S. et al. Minimally invasive operations for acute necrotizing pancreatitis: comparison of minimally invasive retroperitoneal necrosectomy with endoscopic transgastric necrosectomy. Surgery 2012; 152: S128-S134
• 279 Abu Dayyeh BK, Mukewar S, Majumder S. et al. Large-caliber metal stents versus plastic stents for the management of pancreatic walled-off necrosis. Gastrointest Endosc 2018; 87: 141-149
• 280 Bapaye A, Dubale NA, Sheth KA. et al. Endoscopic ultrasonography-guided transmural drainage of walled-off pancreatic necrosis: Comparison between a specially designed fully covered bi-flanged metal stent and multiple plastic stents. Dig Endosc 2017; 29: 104-110
• 281 Mukai S, Itoi T, Baron TH. et al. Endoscopic ultrasound-guided placement of plastic vs. biflanged metal stents for therapy of walled-off necrosis: a retrospective single-center series. Endoscopy 2015; 47: 47-55
• 282 Sharaiha RZ, DeFilippis EM, Kedia P. et al. Metal versus plastic for pancreatic pseudocyst drainage: clinical outcomes and success. Gastrointest Endosc 2015; 82: 822-827
• 283 Bang JY, Navaneethan U, Hasan MK. et al. Non-superiority of lumen-apposing metal stents over plastic stents for drainage of walled-off necrosis in a randomised trial. Gut 2019; 68: 1200-1209
• 284 Stecher SS, Simon P, Friesecke S. et al. Delayed severe bleeding complications after treatment of pancreatic fluid collections with lumen-apposing metal stents. Gut 2017; 66: 1871-1872
• 285 Rana SS, Bhasin DK, Rao C. et al. Consequences of long term indwelling transmural stents in patients with walled off pancreatic necrosis & disconnected pancreatic duct syndrome. Pancreatology 2013; 13: 486-490
• 286 Vipperla K, Papachristou GI, Easler J. et al. Risk of and factors associated with readmission after a sentinel attack of acute pancreatitis. Clin Gastroenterol Hepatol 2014; 12: 1911-1919
• 287 Bertilsson S, Sward P, Kalaitzakis E. Factors That Affect Disease Progression After First Attack of Acute Pancreatitis. Clin Gastroenterol Hepatol 2015; 13: 1662-1669 e1663
• 288 Ahmed Ali U, Issa Y, Hagenaars JC. et al. Risk of Recurrent Pancreatitis and Progression to Chronic Pancreatitis After a First Episode of Acute Pancreatitis. Clin Gastroenterol Hepatol 2016; 14: 738-746
• 289 Nikkola J, Rinta-Kiikka I, Raty S. et al Pancreatic morphological changes in long-term follow-up after initial episode of acute alcoholic pancreatitis. J Gastrointest Surg 2014; 18: 164-170 ; discussion 170-161
• 290 Pelli H, Lappalainen-Lehto R, Piironen A. et al. Pancreatic damage after the first episode of acute alcoholic pancreatitis and its association with the later recurrence rate. Pancreatology 2009; 9: 245-251
• 291 Sankaran SJ, Xiao AY, Wu LM. et al. Frequency of progression from acute to chronic pancreatitis and risk factors: a meta-analysis. Gastroenterology 2015; 149: 1490-1500 e1491
• 292 Chen CH, Dai CY, Hou NJ. et al. Etiology, severity and recurrence of acute pancreatitis in southern taiwan. J Formos Med Assoc 2006; 105: 550-555
• 293 Ho TW, Wu JM, Kuo TC. et al. Change of Both Endocrine and Exocrine Insufficiencies After Acute Pancreatitis in Non-Diabetic Patients: A Nationwide Population-Based Study. Medicine (Baltimore) 2015; 94: e1123
• 294 Munigala S, Conwell DL, Gelrud A. et al. Heavy Smoking Is Associated With Lower Age at First Episode of Acute Pancreatitis and a Higher Risk of Recurrence. Pancreas 2015; 44: 876-881
• 295 Nikkola J, Laukkarinen J, Huhtala H. et al. The Intensity of Brief Interventions in Patients with Acute Alcoholic Pancreatitis Should be Increased, Especially in Young Patients with Heavy Alcohol Consumption. Alcohol Alcohol 2017; 52: 453-459
• 296 Nordback I, Pelli H, Lappalainen-Lehto R. et al. The recurrence of acute alcohol-associated pancreatitis can be reduced: a randomized controlled trial. Gastroenterology 2009; 136: 848-855
• 297 Xiang JX, Hu LS, Liu P. et al. Impact of cigarette smoking on recurrence of hyperlipidemic acute pancreatitis. World J Gastroenterol 2017; 23: 8387-8394
• 298 Ammann RW, Muellhaupt B. Progression of alcoholic acute to chronic pancreatitis. Gut 1994; 35: 552-556
• 299 Yadav D, Lee E, Papachristou GI. et al. A population-based evaluation of readmissions after first hospitalization for acute pancreatitis. Pancreas 2014; 43: 630-637
• 300 Bozkurt T, Maroske D, Adler G. Exocrine pancreatic function after recovery from necrotizing pancreatitis. Hepatogastroenterology 1995; 42: 55-58
• 301 Das SL, Singh PP, Phillips AR. et al. Newly diagnosed diabetes mellitus after acute pancreatitis: a systematic review and meta-analysis. Gut 2014; 63: 818-831
• 302 Nikkola J, Laukkarinen J, Lahtela J. et al. The Long-term Prospective Follow-up of Pancreatic Function After the First Episode of Acute Alcoholic Pancreatitis: Recurrence Predisposes One to Pancreatic Dysfunction and Pancreatogenic Diabetes. J Clin Gastroenterol 2017; 51: 183-190
• 303 Shen HN, Yang CC, Chang YH. et al. Risk of Diabetes Mellitus after First-Attack Acute Pancreatitis: A National Population-Based Study. Am J Gastroenterol 2015; 110: 1698-1706
• 304 Tu J, Zhang J, Ke L. et al. Endocrine and exocrine pancreatic insufficiency after acute pancreatitis: long-term follow-up study. BMC Gastroenterol 2017; 17: 114
• 305 Umapathy C, Raina A, Saligram S. et al. Natural History After Acute Necrotizing Pancreatitis: a Large US Tertiary Care Experience. J Gastrointest Surg 2016; 20: 1844-1853
• 306 Uomo G, Gallucci F, Madrid E. et al. Pancreatic functional impairment following acute necrotizing pancreatitis: long-term outcome of a non-surgically treated series. Dig Liver Dis 2010; 42: 149-152
• 307 Kirkegard J, Cronin-Fenton D, Heide-Jorgensen U. et al. Acute Pancreatitis and Pancreatic Cancer Risk: A Nationwide Matched-Cohort Study in Denmark. Gastroenterology 2018; 154: 1729-1736
• 308 Munigala S, Kanwal F, Xian H. et al. Increased risk of pancreatic adenocarcinoma after acute pancreatitis. Clin Gastroenterol Hepatol 2014; 12: 1143-1150 e1141
• 309 Cho JH, Choi JS, Hwang ET. et al. Usefulness of scheduled follow-up CT in discharged patients with acute pancreatitis. Pancreatology 2015; 15: 642-646
• 310 Poornachandra KS, Bhasin DK, Nagi B. et al. Clinical, biochemical, and radiologic parameters at admission predicting formation of a pseudocyst in acute pancreatitis. J Clin Gastroenterol 2011; 45: 159-163
• 311 Burge MR, Gabaldon-Bates J. The role of ethnicity in post-pancreatitis diabetes mellitus. Diabetes Technol Ther 2003; 5: 183-188
• 312 Bogdan J, Elsaftawy A, Kaczmarzyk J. et al. Epidemiological characteristic of acute pancreatitis in Trzebnica district. Pol Przegl Chir 2012; 84: 70-75
• 313 Nikkola J, Raty S, Laukkarinen J. et al. Abstinence after first acute alcohol-associated pancreatitis protects against recurrent pancreatitis and minimizes the risk of pancreatic dysfunction. Alcohol Alcohol 2013; 48: 483-486
• 314 Kimura Y, Kikuyama M, Kodama Y. Acute Pancreatitis as a Possible Indicator of Pancreatic Cancer: The Importance of Mass Detection. Intern Med 2015; 54: 2109-2114
• 315 Karlson BM, Ekbom A, Josefsson S. et al. The risk of pancreatic cancer following pancreatitis: an association due to confounding?. Gastroenterology 1997; 113: 587-592
• 316 Ekbom A, McLaughlin JK, Karlsson BM. et al. Pancreatitis and pancreatic cancer: a population-based study. J Natl Cancer Inst 1994; 86: 625-627
• 317 Lin CC, Chiang JH, Li CI. et al. Independent and joint effect of type 2 diabetes and gastric and hepatobiliary diseases on risk of pancreatic cancer risk: 10-year follow-up of population-based cohort. Br J Cancer 2014; 111: 2180-2186
• 318 Yadav D, Hawes RH, Brand RE. et al. Alcohol consumption, cigarette smoking, and the risk of recurrent acute and chronic pancreatitis. Arch Intern Med 2009; 169: 1035-1045
• 319 Beagon C, Bhatt NR, Donnelly SM. et al. The Impact of Social Work Intervention in Alcohol-Induced Pancreatitis in Ireland: a Single-Center Experience. Alcohol Alcohol 2015; 50: 438-443
• 320 Chung WS, Lin CL. Incidence and risk of acute coronary syndrome in patients with acute pancreatitis: A nationwide cohort study. Pancreatology 2017; 17: 675-680
• 321 Petrov MS, Yadav D. Global epidemiology and holistic prevention of pancreatitis. Nat Rev Gastroenterol Hepatol 2019; 16: 175-184
• 322 Lankisch PG, Weber-Dany B, Maisonneuve P. et al. Frequency and severity of acute pancreatitis in chronic dialysis patients. Nephrol Dial Transplant 2008; 23: 1401-1405
• 323 Völzke H, Lüdemann J, Mayerle J. et al. Prevalence and determinants of increased serum lipase levels in a general population. Pancreas 2008; 37: 411-417
• 324 Mayerle J, Lerch MM. Akute und chronische Pankreatitis. In: Lammert F, Lynen Jansen P. , M LM, Hrsg. Weissbuch Gastroenterologie 2020/2021. De Gruyter; 2019: 118-122
• 325 Ammann RW, Akovbiantz A, Largiader F. et al. Course and outcome of chronic pancreatitis. Longitudinal study of a mixed medical-surgical series of 245 patients. Gastroenterology 1984; 86: 820-828
• 326 Miyake H, Harada H, Kunichika K. et al. Clinical course and prognosis of chronic pancreatitis. Pancreas 1987; 2: 378-385
• 327 Lankisch PG, Lohr-Happe A, Otto J. et al. Natural course in chronic pancreatitis. Pain, exocrine and endocrine pancreatic insufficiency and prognosis of the disease. Digestion 1993; 54: 148-155
• 328 Gastard J, Joubaud F, Farbos T. et al. Etiology and course of primary chronic pancreatitis in Western France. Digestion 1973; 9: 416-428
• 329 Lowenfels AB, Maisonneuve P, Cavallini G. et al. Prognosis of chronic pancreatitis: an international multicenter study. International Pancreatitis Study Group. Am J Gastroenterol 1994; 89: 1467-1471
• 330 Halangk W, Krüger B, Ruthenbürger M. et al. Trypsin activity is not involved in premature, intrapancreatic trypsinogen activation. Am J Physiol Gastrointest Liver Physiol 2002; 282: G367-G374
• 331 Leppkes M, Maueroder C, Hirth S. et al. Externalized decondensed neutrophil chromatin occludes pancreatic ducts and drives pancreatitis. Nat Commun 2016; 7: 10973
• 332 Kereszturi E, Szmola R, Kukor Z. et al. Hereditary pancreatitis caused by mutation-induced misfolding of human cationic trypsinogen: a novel disease mechanism. Hum Mutat 2009; 30: 575-582
• 333 Gress T, Muller-Pillasch F, Elsasser HP. et al. Enhancement of transforming growth factor beta 1 expression in the rat pancreas during regeneration from caerulein-induced pancreatitis. Eur J Clin Invest 1994; 24: 679-685
• 334 Gress TM, Muller-Pillasch F, Lerch MM. et al. Balance of expression of genes coding for extracellular matrix proteins and extracellular matrix degrading proteases in chronic pancreatitis. Z Gastroenterol 1994; 32: 221-225
• 335 Jeon CY, Whitcomb DC, Slivka A. et al. Lifetime Drinking History of Persons With Chronic Pancreatitis. Alcohol Alcohol 2019; 54: 615-624
• 336 Kleeff J, Whitcomb DC, Shimosegawa T. et al. Chronic pancreatitis. Nat Rev Dis Primers 2017; 3: 17060
• 337 Hoffmeister A, Mayerle J, Beglinger C. et al. English language version of the S3-consensus guidelines on chronic pancreatitis: Definition, aetiology, diagnostic examinations, medical, endoscopic and surgical management of chronic pancreatitis. Z Gastroenterol 2015; 53: 1447-1495
• 338 Durbec JP, Sarles H. Multicenter survey of the etiology of pancreatic diseases. Relationship between the relative risk of developing chronic pancreaitis and alcohol, protein and lipid consumption. Digestion 1978; 18: 337-350
• 339 Johnson CD, Hosking S. National statistics for diet, alcohol consumption, and chronic pancreatitis in England and Wales, 1960-88. Gut 1991; 32: 1401-1405
• 340 Lin Y, Tamakoshi A, Hayakawa T. et al. Associations of alcohol drinking and nutrient intake with chronic pancreatitis: findings from a case-control study in Japan. Am J Gastroenterol 2001; 96: 2622-2627
• 341 Maruyama K, Otsuki M. Incidence of alcoholic pancreatitis in Japanese alcoholics: survey of male sobriety association members in Japan. Pancreas 2007; 34: 63-65
• 342 Sarles H, Cros RC, Bidart JM. A multicenter inquiry into the etiology of pancreatic diseases. Digestion 1979; 19: 110-125
• 343 Stigendal L, Olsson R. Alcohol consumption pattern and serum lipids in alcoholic cirrhosis and pancreatitis. A comparative study. Scand J Gastroenterol 1984; 19: 582-587
• 344 Talamini G, Bassi C, Falconi M. et al. Alcohol and smoking as risk factors in chronic pancreatitis and pancreatic cancer. Dig Dis Sci 1999; 44: 1303-1311
• 345 Levy P, Mathurin P, Roqueplo A. et al. A multidimensional case-control study of dietary, alcohol, and tobacco habits in alcoholic men with chronic pancreatitis. Pancreas 1995; 10: 231-238
• 346 Suda K, Shiotsu H, Nakamura T. et al. Pancreatic fibrosis in patients with chronic alcohol abuse: correlation with alcoholic pancreatitis. Am J Gastroenterol 1994; 89: 2060-2062
• 347 Kume K, Masamune A, Ariga H. et al. Alcohol Consumption and the Risk for Developing Pancreatitis: A Case-Control Study in Japan. Pancreas 2015; 44: 53-58
• 348 Di Leo M, Leandro G, Singh SK. et al. Low Alcohol and Cigarette Use Is Associated to the Risk of Developing Chronic Pancreatitis. Pancreas 2017; 46: 225-229
• 349 Andriulli A, Botteri E, Almasio PL. et al. Smoking as a cofactor for causation of chronic pancreatitis: a meta-analysis. Pancreas 2010; 39: 1205-1210
• 350 Law R, Parsi M, Lopez R. et al. Cigarette smoking is independently associated with chronic pancreatitis. Pancreatology 2010; 10: 54-59
• 351 Maisonneuve P, Lowenfels AB, Mullhaupt B. et al. Cigarette smoking accelerates progression of alcoholic chronic pancreatitis. Gut 2005; 54: 510-514
• 352 Balakrishnan V, Unnikrishnan AG, Thomas V. et al. Chronic pancreatitis. A prospective nationwide study of 1,086 subjects from India. JOP 2008; 9: 593-600
• 353 Conwell DL, Banks PA, Sandhu BS. et al. Validation of Demographics, Etiology, and Risk Factors for Chronic Pancreatitis in the USA: A Report of the North American Pancreas Study (NAPS) Group. Dig Dis Sci 2017; 62: 2133-2140
• 354 Levy P, Barthet M, Mollard BR. et al. Estimation of the prevalence and incidence of chronic pancreatitis and its complications. Gastroenterol Clin Biol 2006; 30: 838-844
• 355 Camara SN, Ramdany S, Zhao G. et al. Etiology, pathology, management and prognosis of chronic pancreatitis in Chinese population: A retrospective study. J Huazhong Univ Sci Technolog Med Sci 2015; 35: 384-389
• 356 Frulloni L, Gabbrielli A, Pezzilli R. et al. Chronic pancreatitis: report from a multicenter Italian survey (PanCroInfAISP) on 893 patients. Dig Liver Dis 2009; 41: 311-317
• 357 Capurso G, Archibugi L, Pasquali P. et al. Prevalence of chronic pancreatitis: Results of a primary care physician-based population study. Dig Liver Dis 2017; 49: 535-539
• 358 Hirota M, Shimosegawa T, Masamune A. et al. The sixth nationwide epidemiological survey of chronic pancreatitis in Japan. Pancreatology 2012; 12: 79-84
• 359 Jacob JJ, John M, Thomas N. et al. Does hyperparathyroidism cause pancreatitis? A South Indian experience and a review of published work. ANZ J Surg 2006; 76: 740-744
• 360 Carnaille B, Oudar C, Pattou F. et al. Pancreatitis and primary hyperparathyroidism: forty cases. Aust N Z J Surg 1998; 68: 117-119
• 361 Janka-Zires M, Hernandez-Calleros J, Gomez-Perez FJ. et al. Decrease in the Prevalence of Pancreatitis Associated with Primary Hyperparathyroidism: Experience at a Tertiary Referral Center. Rev Invest Clin 2015; 67: 177-181
• 362 Kirkegard J, Mortensen FV, Cronin-Fenton D. Chronic Pancreatitis and Pancreatic Cancer Risk: A Systematic Review and Meta-analysis. Am J Gastroenterol 2017; 112: 1366-1372
• 363 Akatsu T, Aiura K, Takahashi S. et al. Recurrent pancreatitis caused by ampullary carcinoma and minor papilla adenoma in familial polyposis: report of a case. Surg Today 2008; 38: 440-444
• 364 Hernández CA, Lerch MM. Sphincter stenosis and gallstone migration through the biliary tract. Lancet (London, England) 1993; 341: 1371-1373
• 365 Yan MX, Li YQ. Gall stones and chronic pancreatitis: the black box in between. Postgrad Med J 2006; 82: 254-258
• 366 Garg PK, Tandon RK. Survey on chronic pancreatitis in the Asia-Pacific region. J Gastroenterol Hepatol 2004; 19: 998-1004
• 367 Talamini G, Falconi M, Bassi C. et al. Previous cholecystectomy, gastrectomy, and diabetes mellitus are not crucial risk factors for pancreatic cancer in patients with chronic pancreatitis. Pancreas 2001; 23: 364-367
• 368 Su WJ, Chen HL, Lai HS. et al. Pancreaticobiliary anomalies is the leading cause of childhood recurrent pancreatitis. J Formos Med Assoc 2007; 106: 119-125
• 369 Whitcomb DC, Gorry MC, Preston RA. et al. Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene. Nat Genet 1996; 14: 141-145
• 370 Witt H, Beer S, Rosendahl J. et al. Variants in CPA1 are strongly associated with early onset chronic pancreatitis. Nat Genet 2013; 45: 1216-1220
• 371 Witt H, Luck W, Hennies HC. et al. Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis. Nat Genet 2000; 25: 213-216
• 372 Fjeld K, Weiss FU, Lasher D. et al. A recombined allele of the lipase gene CEL and its pseudogene CELP confers susceptibility to chronic pancreatitis. Nat Genet 2015; 47: 518-522
• 373 Lasher D, Szabo A, Masamune A. et al. Protease-Sensitive Pancreatic Lipase Variants Are Associated With Early Onset Chronic Pancreatitis. Am J Gastroenterol 2019; 114: 974-983
• 374 Rosendahl J, Witt H, Szmola R. et al. Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis. Nat Genet 2008; 40: 78-82
• 375 Sharer N, Schwarz M, Malone G. et al. Mutations of the cystic fibrosis gene in patients with chronic pancreatitis. N Engl J Med 1998; 339: 645-652
• 376 Weiss FU, Simon P, Bogdanova N. et al. Complete cystic fibrosis transmembrane conductance regulator gene sequencing in patients with idiopathic chronic pancreatitis and controls. Gut 2005; 54: 1456-1460
• 377 Rosendahl J, Kirsten H, Hegyi E. et al. Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis. Gut 2018; 67: 1855-1863
• 378 Whitcomb DC, LaRusch J, Krasinskas AM. et al. Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis. Nat Genet 2012; 44: 1349-1354
• 379 Masson E, Chen JM, Audrezet MP. et al. A conservative assessment of the major genetic causes of idiopathic chronic pancreatitis: data from a comprehensive analysis of PRSS1, SPINK1, CTRC and CFTR genes in 253 young French patients. PLoS One 2013; 8: e73522
• 380 Rosendahl J, Landt O, Bernadova J. et al. CFTR, SPINK1, CTRC and PRSS1 variants in chronic pancreatitis: is the role of mutated CFTR overestimated?. Gut 2013; 62: 582-592
• 381 Weiss FU, Laemmerhirt F, Lerch MM. Next generation sequencing pitfalls in diagnosing trypsinogen (PRSS1) mutations in chronic pancreatitis. Gut 2020;
• 382 GenDG) GügUbMG-. https://wwwgesetze-im-internetde/bundesrecht/gendg/gesamtpdf
• 383 Ammann RW, Buehler H, Muench R. et al. Differences in the natural history of idiopathic (nonalcoholic) and alcoholic chronic pancreatitis. A comparative long-term study of 287 patients. Pancreas 1987; 2: 368-377
• 384 Mullady DK, Yadav D, Amann ST. et al. Type of pain, pain-associated complications, quality of life, disability and resource utilisation in chronic pancreatitis: a prospective cohort study. Gut 2011; 60: 77-84
• 385 Wang LW, Li ZS, Li SD. et al. Prevalence and clinical features of chronic pancreatitis in China: a retrospective multicenter analysis over 10 years. Pancreas 2009; 38: 248-254
• 386 Demir IE, Friess H, Ceyhan GO. Neural plasticity in pancreatitis and pancreatic cancer. Nat Rev Gastroenterol Hepatol 2015; 12: 649-659
• 387 Dimcevski G, Sami SA, Funch-Jensen P. et al. Pain in chronic pancreatitis: the role of reorganization in the central nervous system. Gastroenterology 2007; 132: 1546-1556
• 388 Lelic D, Olesen SS, Graversen C. et al. Electrophysiology as a tool to unravel the origin of pancreatic pain. World J Gastrointest Pathophysiol 2014; 5: 33-39
• 389 Olesen SS, Bouwense SA, Wilder-Smith OH. et al. Pregabalin reduces pain in patients with chronic pancreatitis in a randomized, controlled trial. Gastroenterology 2011; 141: 536-543
• 390 Lohr JM, Oliver MR, Frulloni L. Synopsis of recent guidelines on pancreatic exocrine insufficiency. United European Gastroenterol J 2013; 1: 79-83
• 391 Layer P, Yamamoto H, Kalthoff L. et al. The different courses of early- and late-onset idiopathic and alcoholic chronic pancreatitis. Gastroenterology 1994; 107: 1481-1487
• 392 Keim V, Bauer N, Teich N. et al. Clinical characterization of patients with hereditary pancreatitis and mutations in the cationic trypsinogen gene. Am J Med 2001; 111: 622-626
• 393 DiMagno EP, Go VL, Summerskill WH. Relations between pancreatic enzyme outputs and malabsorption in severe pancreatic insufficiency. N Engl J Med 1973; 288: 813-815
• 394 El Kurdi B, Babar S, El Iskandarani M. et al. Factors That Affect Prevalence of Small Intestinal Bacterial Overgrowth in Chronic Pancreatitis: A Systematic Review, Meta-Analysis, and Meta-Regression. Clin Transl Gastroenterol 2019; 10: e00072
• 395 Frost F, Kacprowski T, Ruhlemann M. et al. Impaired Exocrine Pancreatic Function Associates With Changes in Intestinal Microbiota Composition and Diversity. Gastroenterology 2019; 156: 1010-1015
• 396 Frost F, Weiss FU, Sendler M. et al. The Gut Microbiome in Patients With Chronic Pancreatitis Is Characterized by Significant Dysbiosis and Overgrowth by Opportunistic Pathogens. Clin Transl Gastroenterol 2020; 11: e00232
• 397 Lankisch PG, Dröge M, Hofses S. et al. Steatorrhoea: you cannot trust your eyes when it comes to diagnosis. Lancet (London, England) 1996; 347: 1620-1621
• 398 Fitzsimmons D, Kahl S, Butturini G. et al. Symptoms and quality of life in chronic pancreatitis assessed by structured interview and the EORTC QLQ-C30 and QLQ-PAN26. Am J Gastroenterol 2005; 100: 918-926
• 399 Chowdhury R, Bhutani MS, Mishra G. et al. Comparative analysis of direct pancreatic function testing versus morphological assessment by endoscopic ultrasonography for the evaluation of chronic unexplained abdominal pain of presumed pancreatic origin. Pancreas 2005; 31: 63-68
• 400 Conwell DL, Zuccaro G, Purich E. et al. Comparison of endoscopic ultrasound chronic pancreatitis criteria to the endoscopic secretin-stimulated pancreatic function test. Dig Dis Sci 2007; 52: 1206-1210
• 401 Conwell DL, Zuccaro Jr G, Vargo JJ. et al. Comparison of the secretin stimulated endoscopic pancreatic function test to retrograde pancreatogram. Dig Dis Sci 2007; 52: 1076-1081
• 402 Albashir S, Bronner MP, Parsi MA. et al. Endoscopic ultrasound, secretin endoscopic pancreatic function test, and histology: correlation in chronic pancreatitis. Am J Gastroenterol 2010; 105: 2498-2503
• 403 Yasokawa K, Ito K, Kanki A. et al. Evaluation of pancreatic exocrine insufficiency by cine-dynamic MRCP using spatially selective inversion-recovery (IR) pulse: Correlation with severity of chronic pancreatitis based on morphological changes of pancreatic duct. Magn Reson Imaging 2018; 48: 70-73
• 404 Madzak A, Olesen SS, Haldorsen IS. et al. Secretin-stimulated MRI characterization of pancreatic morphology and function in patients with chronic pancreatitis. Pancreatology 17: 228-236
• 405 Bozkurt T, Braun U, Leferink S. et al. Comparison of pancreatic morphology and exocrine functional impairment in patients with chronic pancreatitis. Gut 1994; 35: 1132-1136
• 406 Lankisch PG, Schmidt I, König H. et al. Faecal elastase 1: not helpful in diagnosing chronic pancreatitis associated with mild to moderate exocrine pancreatic insufficiency. Gut 1998; 42: 551-554
• 407 Siegmund E, Lohr JM, Schuff-Werner P. [The diagnostic validity of non-invasive pancreatic function tests--a meta-analysis]. Z Gastroenterol 2004; 42: 1117-1128
• 408 Keller J, Layer P, Bruckel S. et al. 13C-mixed triglyceride breath test for evaluation of pancreatic exocrine function in diabetes mellitus. Pancreas 2014; 43: 842-848
• 409 Schneider ARJ, Hammerstingl R, Heller M. et al. Does secretin-stimulated MRCP predict exocrine pancreatic insufficiency?: A comparison with noninvasive exocrine pancreatic function tests. J Clin Gastroenterol 2006; 40: 851-855
• 410 Bilgin M, Bilgin S, Balci NC. et al. Magnetic resonance imaging and magnetic resonance cholangiopancreatography findings compared with fecal elastase 1 measurement for the diagnosis of chronic pancreatitis. Pancreas 2008; 36: e33-e39
• 411 Kent DS, Remer T, Blumenthal C. et al. 13C-Mixed Triglyceride Breath Test and Fecal Elastase as an Indirect Pancreatic Function Test in Cystic Fibrosis Infants. J Pediatr Gastroenterol Nutr 2018; 66: 811-815
• 412 de la Iglesia-Garcia D, Vallejo-Senra N, Iglesias-Garcia J. et al. Increased Risk of Mortality Associated With Pancreatic Exocrine Insufficiency in Patients With Chronic Pancreatitis. J Clin Gastroenterol 2018; 52: e63-e72
• 413 Rathmann W, Haastert B, Icks A. et al. High prevalence of undiagnosed diabetes mellitus in Southern Germany: target populations for efficient screening. The KORA survey 2000. Diabetologia 2003; 46: 182-189
• 414 Ewald N, Bretzel RG, Fantus IG. et al. Pancreatin therapy in patients with insulin-treated diabetes mellitus and exocrine pancreatic insufficiency according to low fecal elastase 1 concentrations. Results of a prospective multi-centre trial. Diabetes Metab Res Rev 2007; 23: 386-391
• 415 Lohr M, Kloppel G. [Pathology of the pancreas in chronic type 1 diabetes mellitus: B-cell content, exocrine atrophy and angiopathy]. Verh Dtsch Ges Pathol 1987; 71: 114-119
• 416 Hardt PD, Hauenschild A, Jaeger C. et al. High prevalence of steatorrhea in 101 diabetic patients likely to suffer from exocrine pancreatic insufficiency according to low fecal elastase 1 concentrations: a prospective multicenter study. Dig Dis Sci 2003; 48: 1688-1692
• 417 Issa Y, Kempeneers MA, van Santvoort HC. et al. Diagnostic performance of imaging modalities in chronic pancreatitis: a systematic review and meta-analysis. Eur Radiol 2017; 27: 3820-3844
• 418 Takehara Y, Ichijo K, Tooyama N. et al. Breath-hold MR cholangiopancreatography with a long-echo-train fast spin-echo sequence and a surface coil in chronic pancreatitis. Radiology 1994; 192: 73-78
• 419 Manfredi R, Lucidi V, Gui B. et al. Idiopathic chronic pancreatitis in children: MR cholangiopancreatography after secretin administration. Radiology 2002; 224: 675-682
• 420 Kromrey ML, Bulow R, Hubner J. et al. Prospective study on the incidence, prevalence and 5-year pancreatic-related mortality of pancreatic cysts in a population-based study. Gut 2018; 67: 138-145
• 421 Ammann RW. The natural history of alcoholic chronic pancreatitis. Intern Med 2001; 40: 368-375
• 422 Anderson SW, Soto JA. Pancreatic duct evaluation: accuracy of portal venous phase 64 MDCT. Abdom Imaging 2009; 34: 55-63
• 423 Dimcevski G, Erchinger FG, Havre R. et al. Ultrasonography in diagnosing chronic pancreatitis: new aspects. World J Gastroenterol 2013; 19: 7247-7257
• 424 Engjom T, Sangnes DA, Havre RF. et al. Diagnostic Accuracy of Transabdominal Ultrasound in Chronic Pancreatitis. Ultrasound Med Biol 2017; 43: 735-743
• 425 Takeda K, Goto H, Hirooka Y. et al. Contrast-enhanced transabdominal ultrasonography in the diagnosis of pancreatic mass lesions. Acta Radiol 2003; 44: 103-106
• 426 Wiersema MJ, Hawes RH, Lehman GA. et al. Prospective evaluation of endoscopic ultrasonography and endoscopic retrograde cholangiopancreatography in patients with chronic abdominal pain of suspected pancreatic origin. Endoscopy 1993; 25: 555-564
• 427 Catalano MF, Sahai A, Levy M. et al. EUS-based criteria for the diagnosis of chronic pancreatitis: the Rosemont classification. Gastrointest Endosc 2009; 69: 1251-1261
• 428 Kahl S, Glasbrenner B, Leodolter A. et al. EUS in the diagnosis of early chronic pancreatitis: a prospective follow-up study. Gastrointest Endosc 2002; 55: 507-511
• 429 Janssen J, Schlorer E, Greiner L. EUS elastography of the pancreas: feasibility and pattern description of the normal pancreas, chronic pancreatitis, and focal pancreatic lesions. Gastrointest Endosc 2007; 65: 971-978
• 430 Mayerle J, Beyer G, Simon P. et al. Prospective cohort study comparing transient EUS guided elastography to EUS-FNA for the diagnosis of solid pancreatic mass lesions. Pancreatology 2016; 16: 110-114
• 431 Saftoiu A, Gilja OH, Sidhu PS. et al. The EFSUMB Guidelines and Recommendations for the Clinical Practice of Elastography in Non-Hepatic Applications: Update 2018. Ultraschall Med 2019; 40: 425-453
• 432 Issa Y, van Santvoort HC, Fockens P. et al. Diagnosis and treatment in chronic pancreatitis: an international survey and case vignette study. HPB (Oxford) 2017; 19: 978-985
• 433 Sarner M, Cotton PB. Classification of pancreatitis. Gut 1984; 25: 756-759
• 434 Bagul A, Siriwardena AK. Evaluation of the Manchester classification system for chronic pancreatitis. JOP 2006; 7: 390-396
• 435 Schneider A, Lohr JM, Singer MV. The M-ANNHEIM classification of chronic pancreatitis: introduction of a unifying classification system based on a review of previous classifications of the disease. J Gastroenterol 2007; 42: 101-119
• 436 Etemad B, Whitcomb DC. Chronic pancreatitis: diagnosis, classification, and new genetic developments. Gastroenterology 2001; 120: 682-707
• 437 Whitcomb DC. North American Pancreatitis Study G. Pancreatitis: TIGAR-O Version 2 Risk/Etiology Checklist With Topic Reviews, Updates, and Use Primers. Clin Transl Gastroenterol 2019; 10: e00027
• 438 Buchler MW, Martignoni ME, Friess H. et al. A proposal for a new clinical classification of chronic pancreatitis. BMC Gastroenterol 2009; 9: 93
• 439 Shimosegawa T, Kataoka K, Kamisawa T. et al. The revised Japanese clinical diagnostic criteria for chronic pancreatitis. J Gastroenterol 2010; 45: 584-591
• 440 Beyer G, Mahajan UM, Budde C. et al. Development and Validation of a Chronic Pancreatitis Prognosis Score in 2 Independent Cohorts. Gastroenterology 2017; 153: 1544-1554 e1542
• 441 Issa Y, van Santvoort HC, van Dieren S. et al. Diagnosing Chronic Pancreatitis: Comparison and Evaluation of Different Diagnostic Tools. Pancreas 2017; 46: 1158-1164
• 442 Catalano MF, Sahai A, Levy M. et al. EUS-based criteria for the diagnosis of chronic pancreatitis: the Rosemont classification. Gastrointest Endosc 2009; 69: 1251-1261
• 443 Beyer G, Habtezion A, Werner J. et al. Chronic pancreatitis. The Lancet 2020; 396: 499-512
• 444 Delcore R, Rodriguez FJ, Thomas JH. et al The role of pancreatojejunostomy in patients without dilated pancreatic ducts. Am J Surg 1994; 168: 598-601 ; discussion 601-592
• 445 Malfertheiner P, Mayer D, Buchler M. et al. Treatment of pain in chronic pancreatitis by inhibition of pancreatic secretion with octreotide. Gut 1995; 36: 450-454
• 446 Lieb 2nd JG, Shuster JJ, Theriaque D. et al. A pilot study of Octreotide LAR vs. octreotide tid for pain and quality of life in chronic pancreatitis. JOP 2009; 10: 518-522
• 447 Olesen SS, Graversen C, Bouwense SA. et al. Is Timing of Medical Therapy Related to Outcome in Painful Chronic Pancreatitis?. Pancreas 2016; 45: 381-387
• 448 Talukdar R, Lakhtakia S, Reddy DN. et al. Ameliorating effect of antioxidants and pregabalin combination in pain recurrence after ductal clearance in chronic pancreatitis: Results of a randomized, double blind, placebo-controlled trial. Journal of Gastroenterology and Hepatology 2016; 31: 1654-1662
• 449 Gurusamy KS, Lusuku C, Davidson BR. Pregabalin for decreasing pancreatic pain in chronic pancreatitis. Cochrane Database Syst Rev 2016; 2: Cd011522
• 450 Shafiq N, Rana S, Bhasin D. et al. Pancreatic enzymes for chronic pancreatitis. Cochrane Database Syst Rev 2009; Cd006302
• 451 de la Iglesia-Garcia D, Huang W, Szatmary P. et al. Efficacy of pancreatic enzyme replacement therapy in chronic pancreatitis: systematic review and meta-analysis. Gut 2017; 66: 1354-1355
• 452 Ahmed Ali U, Jens S, Busch OR. et al. Antioxidants for pain in chronic pancreatitis. Cochrane Database Syst Rev 2014; Cd008945
• 453 Zhou D, Wang W, Cheng X. et al. Antioxidant therapy for patients with chronic pancreatitis: A systematic review and meta-analysis. Clin Nutr 2015; 34: 627-634
• 454 Talukdar R, Murthy HV, Reddy DN. Role of methionine containing antioxidant combination in the management of pain in chronic pancreatitis: a systematic review and meta-analysis. Pancreatology 2015; 15: 136-144
• 455 Rustagi T, Njei B. Antioxidant therapy for pain reduction in patients with chronic pancreatitis: a systematic review and meta-analysis. Pancreas 2015; 44: 812-818
• 456 Gooshe M, Abdolghaffari AH, Nikfar S. et al. Antioxidant therapy in acute, chronic and post-endoscopic retrograde cholangiopancreatography pancreatitis: An updated systematic review and meta-analysis. World J Gastroenterol 2015; 21: 9189-9208
• 457 Wiese M, Gärtner S, Doller J. et al. Nutritional management of chronic pancreatitis: A systematic review and meta-analysis of randomized controlled trials. J Gastroenterol Hepatol 2021; 36: 588-600
• 458 Omenn GS, Goodman GE, Thornquist MD. et al. Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med 1996; 334: 1150-1155
• 459 [Anonym]. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. N Engl J Med 1994; 330: 1029-1035
• 460 Cartmell MT, O’Reilly DA, Porter C. et al. A double-blind placebo-controlled trial of a leukotriene receptor antagonist in chronic pancreatitis in humans. J Hepatobiliary Pancreat Surg 2004; 11: 255-259
• 461 Hebuterne X, Hastier P, Peroux JL. et al. Resting energy expenditure in patients with alcoholic chronic pancreatitis. Dig Dis Sci 1996; 41: 533-539
• 462 DiMagno EP, Clain JE, Layer P. Chronic pancreatitis. In: Go VL. , Hrsg. The pancreas Biology, pathobiology, and disease. New York: Raven Press; 1993: 665-706
• 463 Twersky Y, Bank S. Nutritional deficiencies in chronic pancreatitis. Gastroenterol Clin North Am 1989; 18: 543-565
• 464 Layer P, von der Ohe MR, Holst JJ. et al. Altered postprandial motility in chronic pancreatitis: role of malabsorption. Gastroenterology 1997; 112: 1624-1634
• 465 DiMagno EP. Medical treatment of pancreatic insufficiency. Mayo Clin Proc 1979; 54: 435-442
• 466 Braden B, Picard H, Caspary WF. et al. Monitoring pancreatin supplementation in cystic fibrosis patients with the 13C-Hiolein breath test: evidence for normalized fat assimilation with high dose pancreatin therapy. Z Gastroenterol 1997; 35: 123-129
• 467 Dominguez Munoz JE. Diagnosis of chronic pancreatitis: Functional testing. Best Pract Res Clin Gastroenterol 24: 233-241
• 468 Dominguez-Munoz JE, Iglesias-Garcia J. Oral pancreatic enzyme substitution therapy in chronic pancreatitis: is clinical response an appropriate marker for evaluation of therapeutic efficacy?. JOP 11: 158-162
• 469 Dominguez-Munoz JE, Iglesias-Garcia J, Vilarino-Insua M. et al. 13C-mixed triglyceride breath test to assess oral enzyme substitution therapy in patients with chronic pancreatitis. Clin Gastroenterol Hepatol 2007; 5: 484-488
• 470 Keller J, Aghdassi AA, Lerch MM. et al. Tests of pancreatic exocrine function – clinical significance in pancreatic and non-pancreatic disorders. Best Pract Res Clin Gastroenterol 2009; 23: 425-439
• 471 Lembcke B, Konle O, Duan LP. et al. Lack of accuracy of plasma alpha-amino nitrogen profiles as an indicator of exocrine pancreatic function both after continuous and bolus stimulation of the pancreas with secretin and cholecystokinin-pancreozymin. Z Gastroenterol 1994; 32: 679-683
• 472 Loser C, Brauer C, Aygen S. et al. Comparative clinical evaluation of the 13C-mixed triglyceride breath test as an indirect pancreatic function test. Scand J Gastroenterol 1998; 33: 327-334
• 473 Loser C, Mollgaard A, Aygen S. et al. 13C-starch breath test--comparative clinical evaluation of an indirect pancreatic function test. Z Gastroenterol 1997; 35: 187-194
• 474 Loser C, Mollgaard A, Folsch UR. Faecal elastase 1: a novel, highly sensitive, and specific tubeless pancreatic function test. Gut 1996; 39: 580-586
• 475 Ritz MA, Fraser RJ, Di Matteo AC. et al. Evaluation of the 13C-triolein breath test for fat malabsorption in adult patients with cystic fibrosis. J Gastroenterol Hepatol 2004; 19: 448-453
• 476 Ventrucci M, Cipolla A, Ubalducci GM. et al. 13C labelled cholesteryl octanoate breath test for assessing pancreatic exocrine insufficiency. Gut 1998; 42: 81-87
• 477 Ventrucci M, Gullo L, Daniele C. et al. Pancreolauryl test for pancreatic exocrine insufficiency. Am J Gastroenterol 1983; 78: 806-809
• 478 Weiss FU, Budde C, Lerch MM. Specificity of a Polyclonal Fecal Elastase ELISA for CELA3. PLoS One 2016; 11: e0159363
• 479 DiMagno EP, Malagelada JR, Go VL. et al. Fate of orally ingested enzymes in pancreatic insufficiency. Comparison of two dosage schedules. N Engl J Med 1977; 296: 1318-1322
• 480 Graham DY. Enzyme replacement therapy of exocrine pancreatic insufficiency in man. Relations between in vitro enzyme activities and in vivo potency in commercial pancreatic extracts. N Engl J Med 1977; 296: 1314-1317
• 481 Dominguez-Munoz JE, Iglesias-Garcia J, Iglesias-Rey M. et al. Effect of the administration schedule on the therapeutic efficacy of oral pancreatic enzyme supplements in patients with exocrine pancreatic insufficiency: a randomized, three-way crossover study. Aliment Pharmacol Ther 2005; 21: 993-1000
• 482 Kolbel C, Layer P, Hotz J. et al. Effect of an acid protected, micro-encapsulated pancreatin preparation on pancreatogenic steatorrhea. Med Klin (Munich) 1986; 81: 85-86
• 483 Meyer JH, Lake R, Elashoff JD. Postcibal gastric emptying of pancreatin pellets: effects of dose and meal oil. Dig Dis Sci 2001; 46: 1846-1852
• 484 Regan PT, Malagelada JR, DiMagno EP. et al. Comparative effects of antacids, cimetidine and enteric coating on the therapeutic response to oral enzymes in severe pancreatic insufficiency. N Engl J Med 1977; 297: 854-858
• 485 Dominguez-Munoz JE, Iglesias-Garcia J. Oral pancreatic enzyme substitution therapy in chronic pancreatitis: is clinical response an appropriate marker for evaluation of therapeutic efficacy?. Jop 2010; 11: 158-162
• 486 Whitehead AM. Study to compare the enzyme activity, acid resistance and dissolution characteristics of currently available pancreatic enzyme preparations. Pharm Weekbl Sci 1988; 10: 12-16
• 487 Suzuki A, Mizumoto A, Sarr MG. et al. Bacterial lipase and high-fat diets in canine exocrine pancreatic insufficiency: a new therapy of steatorrhea?. Gastroenterology 1997; 112: 2048-2055
• 488 Malesci A, Mariani A, Mezzi G. et al. New enteric-coated high-lipase pancreatic extract in the treatment of pancreatic steatorrhea. J Clin Gastroenterol 1994; 18: 32-35
• 489 Whitcomb DC, Lehman GA, Vasileva G. et al. Pancrelipase delayed-release capsules (CREON) for exocrine pancreatic insufficiency due to chronic pancreatitis or pancreatic surgery: A double-blind randomized trial. Am J Gastroenterol 2010; 105: 2276-2286
• 490 Thorat V, Reddy N, Bhatia S. et al. Randomised clinical trial: the efficacy and safety of pancreatin enteric-coated minimicrospheres (Creon 40000 MMS) in patients with pancreatic exocrine insufficiency due to chronic pancreatitis--a double-blind, placebo-controlled study. Aliment Pharmacol Ther 2012; 36: 426-436
• 491 Löhr JM, Dominguez-Munoz E, Rosendahl J. et al. United European Gastroenterology evidence-based guidelines for the diagnosis and therapy of chronic pancreatitis (HaPanEU). United European Gastroenterol J 2017; 5: 153-199
• 492 Capurso G, Signoretti M, Archibugi L. et al. Systematic review and meta-analysis: Small intestinal bacterial overgrowth in chronic pancreatitis. United European Gastroenterol J 2016; 4: 697-705
• 493 Smyth RL, van Velzen D, Smyth AR. et al. Strictures of ascending colon in cystic fibrosis and high-strength pancreatic enzymes. Lancet (London, England) 1994; 343: 85-86
• 494 Smyth RL, Ashby D, O’Hea U. et al. Fibrosing colonopathy in cystic fibrosis: results of a case-control study. Lancet (London, England) 1995; 346: 1247-1251
• 495 Serban DE, Florescu P, Miu N. Fibrosing colonopathy revealing cystic fibrosis in a neonate before any pancreatic enzyme supplementation. J Pediatr Gastroenterol Nutr 2002; 35: 356-359
• 496 Taylor CJ. Fibrosing colonopathy unrelated to pancreatic enzyme supplementation. J Pediatr Gastroenterol Nutr 2002; 35: 268-269
• 497 Waters BL. Cystic fibrosis with fibrosing colonopathy in the absence of pancreatic enzymes. Pediatr Dev Pathol 1998; 1: 74-78
• 498 Connett GJ, Lucas JS, Atchley JT. et al. Colonic wall thickening is related to age and not dose of high strength pancreatin microspheres in children with cystic fibrosis. Eur J Gastroenterol Hepatol 1999; 11: 181-183
• 499 O’Keefe SJ, Cariem AK, Levy M. The exacerbation of pancreatic endocrine dysfunction by potent pancreatic exocrine supplements in patients with chronic pancreatitis. J Clin Gastroenterol 2001; 32: 319-323
• 500 Whitcomb DC, Bodhani A, Beckmann K. et al. Efficacy and Safety of Pancrelipase/Pancreatin in Patients With Exocrine Pancreatic Insufficiency and a Medical History of Diabetes Mellitus. Pancreas 2016; 45: 679-686
• 501 Ebert R, Creutzfeldt W. Reversal of impaired GIP and insulin secretion in patients with pancreatogenic steatorrhea following enzyme substitution. Diabetologia 1980; 19: 198-204
• 502 Perano SJ, Couper JJ, Horowitz M. et al. Pancreatic enzyme supplementation improves the incretin hormone response and attenuates postprandial glycemia in adolescents with cystic fibrosis: a randomized crossover trial. J Clin Endocrinol Metab 2014; 99: 2486-2493
• 503 Nicolas JM, Estruch R, Antunez E. et al. Nutritional status in chronically alcoholic men from the middle socioeconomic class and its relation to ethanol intake. Alcohol Alcohol 1993; 28: 551-558
• 504 Singh S, Midha S, Singh N. et al. Dietary counseling versus dietary supplements for malnutrition in chronic pancreatitis: a randomized controlled trial. Clin Gastroenterol Hepatol 2008; 6: 353-359
• 505 Arvanitakis M, Ockenga J, Bezmarevic M. et al. ESPEN guideline on clinical nutrition in acute and chronic pancreatitis. Clin Nutr 2020; 39: 612-631
• 506 Scolapio JS, Malhi-Chowla N, Ukleja A. Nutrition supplementation in patients with acute and chronic pancreatitis. Gastroenterol Clin North Am 1999; 28: 695-707
• 507 Caliari S, Benini L, Sembenini C. et al. Medium-chain triglyceride absorption in patients with pancreatic insufficiency. Scand J Gastroenterol 1996; 31: 90-94
• 508 Gianotti L, Meier R, Lobo DN. et al. ESPEN Guidelines on Parenteral Nutrition: pancreas. Clin Nutr 2009; 28: 428-435
• 509 Meier R, Ockenga J, Pertkiewicz M. et al. ESPEN Guidelines on Enteral Nutrition: Pancreas. Clin Nutr 2006; 25: 275-284
• 510 Gullo L, Barbara L, Labo G. Effect of cessation of alcohol use on the course of pancreatic dysfunction in alcoholic pancreatitis. Gastroenterology 1988; 95: 1063-1068
• 511 Chauhan S, Forsmark CE. Pain management in chronic pancreatitis: A treatment algorithm. Best Pract Res Clin Gastroenterol 2010; 24: 323-335
• 512 Drewes AM, Kempeneers MA, Andersen DK. et al. Controversies on the endoscopic and surgical management of pain in patients with chronic pancreatitis: pros and cons!. Gut 2019; 68: 1343-1351
• 513 Beyer G, Habtezion A, Werner J. et al. Chronic pancreatitis. Lancet 2020; 396: 499-512
• 514 Kleeff J, Stöß C, Mayerle J. et al. Evidence-Based Surgical Treatments for Chronic Pancreatitis. Dtsch Arztebl Int 2016; 113: 489-496
• 515 Díte P, Ruzicka M, Zboril V. et al. A prospective, randomized trial comparing endoscopic and surgical therapy for chronic pancreatitis. Endoscopy 2003; 35: 553-558
• 516 Cahen DL, Gouma DJ, Laramée P. et al. Long-term outcomes of endoscopic vs surgical drainage of the pancreatic duct in patients with chronic pancreatitis. Gastroenterology 2011; 141: 1690-1695
• 517 Cahen DL, Gouma DJ, Nio Y. et al. Endoscopic versus surgical drainage of the pancreatic duct in chronic pancreatitis. N Engl J Med 2007; 356: 676-684
• 518 Issa Y, Kempeneers MA, Bruno MJ. et al. Effect of Early Surgery vs Endoscopy-First Approach on Pain in Patients With Chronic Pancreatitis: The ESCAPE Randomized Clinical Trial. Jama 2020; 323: 237-247
• 519 Fusaroli P, Jenssen C, Hocke M. et al. EFSUMB Guidelines on Interventional Ultrasound (INVUS), Part V – EUS-Guided Therapeutic Interventions (short version). Ultraschall Med 2016; 37: 412-420
• 520 Conroy T, Hammel P, Hebbar M. et al. FOLFIRINOX or Gemcitabine as Adjuvant Therapy for Pancreatic Cancer. N Engl J Med 2018; 379: 2395-2406
• 521 Burris 3rd HA, Moore MJ, Andersen J. et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol 1997; 15: 2403-2413
• 522 Neoptolemos JP, Stocken DD, Bassi C. et al. Adjuvant chemotherapy with fluorouracil plus folinic acid vs gemcitabine following pancreatic cancer resection: a randomized controlled trial. JAMA 304: 1073-1081
• 523 Bachmann K, Tomkoetter L, Erbes J. et al. Beger and Frey procedures for treatment of chronic pancreatitis: comparison of outcomes at 16-year follow-up. J Am Coll Surg 2014; 219: 208-216
• 524 Seza K, Yamaguchi T, Ishihara T. et al. A long-term controlled trial of endoscopic pancreatic stenting for treatment of main pancreatic duct stricture in chronic pancreatitis. Hepatogastroenterology 2011; 58: 2128-2131
• 525 Beger HG, Schlosser W, Friess HM. et al Duodenum-preserving head resection in chronic pancreatitis changes the natural course of the disease: a single-center 26-year experience. Ann Surg 1999; 230: 512-519 ; discussion 519-523
• 526 Diener MK, Hüttner FJ, Kieser M. et al. Partial pancreatoduodenectomy versus duodenum-preserving pancreatic head resection in chronic pancreatitis: the multicentre, randomised, controlled, double-blind ChroPac trial. Lancet 2017; 390: 1027-1037
• 527 Devière J, Nageshwar Reddy D, Püspök A. et al Successful management of benign biliary strictures with fully covered self-expanding metal stents. Gastroenterology 2014; 147: 385-395 ; quiz e315
• 528 Perri V, Boškoski I, Tringali A. et al. Fully covered self-expandable metal stents in biliary strictures caused by chronic pancreatitis not responding to plastic stenting: a prospective study with 2 years of follow-up. Gastrointest Endosc 2012; 75: 1271-1277
• 529 Poley J-W, Cahen DL, Metselaar HJ. et al. A prospective group sequential study evaluating a new type of fully covered self-expandable metal stent for the treatment of benign biliary strictures (with video). Gastrointest Endosc 2012; 75: 783-789
• 530 Schmidt A, Pickartz T, Lerch MM. et al. Effective treatment of benign biliary strictures with a removable, fully covered, self-expandable metal stent: A prospective, multicenter European study. United European Gastroenterol J 2017; 5: 398-407
• 531 Lakhtakia S, Reddy N, Dolak W. et al. Long-term outcomes after temporary placement of a self-expanding fully covered metal stent for benign biliary strictures secondary to chronic pancreatitis. Gastrointest Endosc 2020; 91: 361-369.e363
• 532 Cahen DL, van Berkel AM, Oskam D. et al. Long-term results of endoscopic drainage of common bile duct strictures in chronic pancreatitis. Eur J Gastroenterol Hepatol 2005; 17: 103-108
• 533 Cahen DL, Gouma DJ, Nio Y. et al. Endoscopic versus surgical drainage of the pancreatic duct in chronic pancreatitis. N Engl J Med 2007; 356: 676-684
• 534 Catalano MF, Linder JD, George S. et al. Treatment of symptomatic distal common bile duct stenosis secondary to chronic pancreatitis: comparison of single vs. multiple simultaneous stents. Gastrointest Endosc 2004; 60: 945-952
• 535 Ohyama H, Mikata R, Ishihara T. et al. Efficacy of multiple biliary stenting for refractory benign biliary strictures due to chronic calcifying pancreatitis. World J Gastrointest Endosc 2017; 9: 12-18
• 536 Khan MA, Baron TH, Kamal F. et al. Efficacy of self-expandable metal stents in management of benign biliary strictures and comparison with multiple plastic stents: a meta-analysis. Endoscopy 2017; 49: 682-694
• 537 Kahl S, Zimmermann S, Genz I. et al. Risk factors for failure of endoscopic stenting of biliary strictures in chronic pancreatitis: a prospective follow-up study. Am J Gastroenterol 2003; 98: 2448-2453
• 538 Mayerle J, Anz D, D’Haese JG. et al. Endoscopic and surgical treatment of chronic pancreatitis. Internist (Berl) 2019; 60: 235-246
• 539 Lerch MM, Stier A, Wahnschaffe U. et al. Pancreatic pseudocysts: observation, endoscopic drainage, or resection?. Dtsch Arztebl Int 2009; 106: 614-621
• 540 Bartoli E, Delcenserie R, Yzet T. et al. Endoscopic treatment of chronic pancreatitis. Gastroenterol Clin Biol 2005; 29: 515-521
• 541 Cheruvu CV, Clarke MG, Prentice M. et al. Conservative treatment as an option in the management of pancreatic pseudocyst. Annals of the Royal College of Surgeons of England 2003; 85: 313-316
• 542 Nealon WH, Walser E. Duct drainage alone is sufficient in the operative management of pancreatic pseudocyst in patients with chronic pancreatitis. Ann Surg 2003; 237: 614-620 ; discussion 620-612
• 543 Traverso LW, Tompkins RK, Urrea PT. et al. Surgical treatment of chronic pancreatitis. Twenty-two years’ experience. Ann Surg 1979; 190: 312-319
• 544 Usatoff V, Brancatisano R, Williamson RC. Operative treatment of pseudocysts in patients with chronic pancreatitis. Br J Surg 2000; 87: 1494-1499
• 545 Johnson MD, Walsh RM, Henderson JM. et al. Surgical versus nonsurgical management of pancreatic pseudocysts. J Clin Gastroenterol 2009; 43: 586-590
• 546 Gurusamy KS, Pallari E, Hawkins N. et al. Management strategies for pancreatic pseudocysts. Cochrane Database Syst Rev 2016; 4: CD011392
• 547 Jiang TA, Xie LT. Algorithm for the multidisciplinary management of hemorrhage in EUS-guided drainage for pancreatic fluid collections. World J Clin Cases 2018; 6: 308-321
• 548 Gouyon B, Lévy P, Ruszniewski P. et al. Predictive factors in the outcome of pseudocysts complicating alcoholic chronic pancreatitis. Gut 1997; 41: 821-825
• 549 Bradley EL, Clements Jr JL, Gonzalez AC. The natural history of pancreatic pseudocysts: a unified concept of management. Am J Surg 1979; 137: 135-141
• 550 Lankisch PG, Weber-Dany B, Maisonneuve P. et al. Pancreatic pseudocysts: prognostic factors for their development and their spontaneous resolution in the setting of acute pancreatitis. Pancreatology 2012; 12: 85-90
• 551 Teoh AYB, Dhir V, Kida M. et al. Consensus guidelines on the optimal management in interventional EUS procedures: results from the Asian EUS group RAND/UCLA expert panel. Gut 2018; 67: 1209-1228
• 552 Kamal A, Singh VK, Akshintala VS. et al. CT and MRI assessment of symptomatic organized pancreatic fluid collections and pancreatic duct disruption: an interreader variability study using the revised Atlanta classification 2012. Abdom Imaging 2015; 40: 1608-1616
• 553 Rana SS, Chaudhary V, Sharma R. et al. Comparison of abdominal ultrasound, endoscopic ultrasound and magnetic resonance imaging in detection of necrotic debris in walled-off pancreatic necrosis. Gastroenterol Rep (Oxf) 2016; 4: 50-53
• 554 Delhaye M, Matos C, Devière J. Endoscopic management of chronic pancreatitis. Gastrointestinal endoscopy clinics of North America 2003; 13: 717-742
• 555 Kwon CI, Gromski MA, Sherman S. et al. Clinical response to dorsal duct drainage via the minor papilla in refractory obstructing chronic calcific pancreatitis. Endoscopy 2017; 49: 371-377
• 556 Bang JY, Wilcox CM, Trevino J. et al. Factors impacting treatment outcomes in the endoscopic management of walled-off pancreatic necrosis. J Gastroenterol Hepatol 2013; 28: 1725-1732
• 557 Arvanitakis M, Delhaye M, Bali MA. et al. Pancreatic-fluid collections: a randomized controlled trial regarding stent removal after endoscopic transmural drainage. Gastrointest Endosc 2007; 65: 609-619
• 558 Drake LM, Anis M, Lawrence C. Accuracy of magnetic resonance cholangiopancreatography in identifying pancreatic duct disruption. J Clin Gastroenterol 2012; 46: 696-699
• 559 Dumonceau JM, Delhaye M, Tringali A. et al. Endoscopic treatment of chronic pancreatitis: European Society of Gastrointestinal Endoscopy (ESGE) Guideline – Updated August 2018. Endoscopy 2019; 51: 179-193
• 560 Barthet M, Sahel J, Bodiou-Bertei C. et al. Endoscopic transpapillary drainage of pancreatic pseudocysts. Gastrointest Endosc 1995; 42: 208-213
• 561 Yang D, Amin S, Gonzalez S. et al. Transpapillary drainage has no added benefit on treatment outcomes in patients undergoing EUS-guided transmural drainage of pancreatic pseudocysts: a large multicenter study. Gastrointest Endosc 2016; 83: 720-729
• 562 Barthet M, Lamblin G, Gasmi M. et al. Clinical usefulness of a treatment algorithm for pancreatic pseudocysts. Gastrointest Endosc 2008; 67: 245-252
• 563 Hookey LC, Debroux S, Delhaye M. et al. Endoscopic drainage of pancreatic-fluid collections in 116 patients: a comparison of etiologies, drainage techniques, and outcomes. Gastrointest Endosc 2006; 63: 635-643
• 564 Cahen D, Rauws E, Fockens P. et al. Endoscopic drainage of pancreatic pseudocysts: long-term outcome and procedural factors associated with safe and successful treatment. Endoscopy 2005; 37: 977-983
• 565 Libera ED, Siqueira ES, Morais M. et al. Pancreatic pseudocysts transpapillary and transmural drainage. HPB Surg 2000; 11: 333-338
• 566 Binmoeller KF, Seifert H, Walter A. et al. Transpapillary and transmural drainage of pancreatic pseudocysts. Gastrointest Endosc 1995; 42: 219-224
• 567 Eleftherladis N, Dinu F, Delhaye M. et al. Long-term outcome after pancreatic stenting in severe chronic pancreatitis. Endoscopy 2005; 37: 223-230
• 568 Farnbacher MJ, Mühldorfer S, Wehler M. et al. Interventional endoscopic therapy in chronic pancreatitis including temporary stenting: a definitive treatment?. Scand J Gastroenterol 2006; 41: 111-117
• 569 Varadarajulu S, Christein JD, Tamhane A. et al. Prospective randomized trial comparing EUS and EGD for transmural drainage of pancreatic pseudocysts (with videos). Gastrointest Endosc 2008; 68: 1102-1111
• 570 Panamonta N, Ngamruengphong S, Kijsirichareanchai K. et al. Endoscopic ultrasound-guided versus conventional transmural techniques have comparable treatment outcomes in draining pancreatic pseudocysts. Eur J Gastroenterol Hepatol 2012; 24: 1355-1362
• 571 Bang JY, Hawes RH, Varadarajulu S. Lumen-apposing metal stent placement for drainage of pancreatic fluid collections: predictors of adverse events. Gut 2020; 69: 1379-1381
• 572 Bang JY, Wilcox CM, Trevino JM. et al. Relationship between stent characteristics and treatment outcomes in endoscopic transmural drainage of uncomplicated pancreatic pseudocysts. Surg Endosc 2014; 28: 2877-2883
• 573 Lin H, Zhan XB, Sun SY. et al. Stent selection for endoscopic ultrasound-guided drainage of pancreatic fluid collections: a multicenter study in china. Gastroenterol Res Pract 2014; 2014: 193562
• 574 Panwar R, Singh PM. Efficacy and safety of metallic stents in comparison to plastic stents for endoscopic drainage of peripancreatic fluid collections: a meta-analysis and trial sequential analysis. Clin J Gastroenterol 2017; 10: 403-414
• 575 Yoon SB, Lee IS, Choi MG. Metal versus plastic stents for drainage of pancreatic fluid collection: A meta-analysis. United European Gastroenterol J 2018; 6: 729-738
• 576 Chen YI, Khashab MA, Adam V. et al. Plastic stents are more cost-effective than lumen-apposing metal stents in management of pancreatic pseudocysts. Endosc Int Open 2018; 6: E780-E788
• 577 Chen YI, Barkun AN, Adam V. et al. Cost-effectiveness analysis comparing lumen-apposing metal stents with plastic stents in the management of pancreatic walled-off necrosis. Gastrointest Endosc 2018; 88: 267-276.e261
• 578 Arvanitakis M, Dumonceau JM, Albert J. et al. Endoscopic management of acute necrotizing pancreatitis: European Society of Gastrointestinal Endoscopy (ESGE) evidence-based multidisciplinary guidelines. Endoscopy 2018; 50: 524-546
• 579 Tanaka M, Chari S, Adsay V. et al. International consensus guidelines for management of intraductal papillary mucinous neoplasms and mucinous cystic neoplasms of the pancreas. Pancreatology 2006; 6: 17-32
• 580 [Anonym]. European evidence-based guidelines on pancreatic cystic neoplasms. Gut 2018; 67: 789-804
• 581 Tanaka M, Fernández-Del Castillo C, Kamisawa T. et al. Revisions of international consensus Fukuoka guidelines for the management of IPMN of the pancreas. Pancreatology 2017; 17: 738-753
• 582 Grützmann R, Niedergethmann M, Pilarsky C. et al. Intraductal papillary mucinous tumors of the pancreas: biology, diagnosis, and treatment. Oncologist 2010; 15: 1294-1309
• 583 Megibow AJ, Baker ME, Gore RM. et al. The incidental pancreatic cyst. Radiol Clin North Am 2011; 49: 349-359
• 584 Werner JB, Bartosch-Härlid A, Andersson R. Cystic pancreatic lesions: current evidence for diagnosis and treatment. Scand J Gastroenterol 2011; 46: 773-788
• 585 Udd M, Leppaniemi AK, Bidel S. et al. Treatment of bleeding pseudoaneurysms in patients with chronic pancreatitis. World J Surg 2007; 31: 504-510
• 586 van Huijgevoort NCM, Veld JV, Fockens P. et al. Success of extracorporeal shock wave lithotripsy and ERCP in symptomatic pancreatic duct stones: a systematic review and meta-analysis. Endosc Int Open 2020; 8: E1070-E1085
• 587 Saghir SM, Mashiana HS, Mohan BP. et al. Efficacy of pancreatoscopy for pancreatic duct stones: A systematic review and meta-analysis. World J Gastroenterol 2020; 26: 5207-5219
• 588 Treacy PJ, Worthley CS. Pancreatic stents in the management of chronic pancreatitis. Aust N Z J Surg 1996; 66: 210-213
• 589 Rösch T, Daniel S, Scholz M. et al. Endoscopic treatment of chronic pancreatitis: a multicenter study of 1000 patients with long-term follow-up. Endoscopy 2002; 34: 765-771
• 590 Menges M, Lerch MM, Zeitz M. The double duct sign in patients with malignant and benign pancreatic lesions. Gastrointest Endosc 2000; 52: 74-77
• 591 Jafri M, Sachdev A, Sadiq J. et al. Efficacy of Endotherapy in the Treatment of Pain Associated With Chronic Pancreatitis: A Systematic Review and Meta-Analysis. Jop 2017; 18: 125-132
• 592 Costamagna G, Bulajic M, Tringali A. et al. Multiple stenting of refractory pancreatic duct strictures in severe chronic pancreatitis: long-term results. Endoscopy 2006; 38: 254-259
• 593 Tringali A, Bove V, Vadalà di Prampero SF. et al. Long-term follow-up after multiple plastic stenting for refractory pancreatic duct strictures in chronic pancreatitis. Endoscopy 2019; 51: 930-935
• 594 Tringali A, Vadalà di Prampero SF, Landi R. et al. Fully covered self-expandable metal stents to dilate persistent pancreatic strictures in chronic pancreatitis: long-term follow-up from a prospective study. Gastrointest Endosc 2018; 88: 939-946
• 595 Korpela T, Udd M, Lindström O. et al. Fully covered self-expanding metal stents for benign refractory pancreatic duct strictures in chronic pancreatitis. Scand J Gastroenterol 2019; 54: 365-370
• 596 Dumonceau J-M, Costamagna G, Tringali A. et al. Treatment for painful calcified chronic pancreatitis: extracorporeal shock wave lithotripsy versus endoscopic treatment: a randomised controlled trial. Gut 2007; 56: 545-552
• 597 Ito K, Igarashi Y, Okano N. et al. Efficacy of combined endoscopic lithotomy and extracorporeal shock wave lithotripsy, and additional electrohydraulic lithotripsy using the SpyGlass direct visualization system or X-ray guided EHL as needed, for pancreatic lithiasis. Biomed Res Int 2014; 2014: 732781
• 598 Kuftinec G, Zavadski Y, Tejaswi S. Digital pancreatoscopy with electrohydraulic lithotripsy to treat a pancreatic duct stone. VideoGIE 2017; 2: 205-207
• 599 Gutt C, Jenssen C, Barreiros AP. et al. Updated S3-Guideline for Prophylaxis, Diagnosis and Treatment of Gallstones. German Society for Digestive and Metabolic Diseases (DGVS) and German Society for Surgery of the Alimentary Tract (DGAV) – AWMF Registry 021/008. Z Gastroenterol 2018; 56: 912-966
• 600 Abdallah AA, Krige JEJ, Bornman PC. Biliary tract obstruction in chronic pancreatitis. HPB (Oxford) 2007; 9: 421-428
• 601 Frey CF, Suzuki M, Isaji S. Treatment of chronic pancreatitis complicated by obstruction of the common bile duct or duodenum. World J Surg 1990; 14: 59-69
• 602 Park JS, Lee SS, Song TJ. et al. Long-term outcomes of covered self-expandable metal stents for treating benign biliary strictures. Endoscopy 2016; 48: 440-447
• 603 Moran RA, Coté GA. EXPAND your practice by using fully covered metallic stents as first-line treatment for chronic pancreatitis-induced bile duct strictures. Gastrointest Endosc 2020; 91: 370-372
• 604 Coté GA, Slivka A, Tarnasky P. et al. Effect of Covered Metallic Stents Compared With Plastic Stents on Benign Biliary Stricture Resolution: A Randomized Clinical Trial. Jama 2016; 315: 1250-1257
• 605 Haapamäki C, Kylänpää L, Udd M. et al. Randomized multicenter study of multiple plastic stents vs. covered self-expandable metallic stent in the treatment of biliary stricture in chronic pancreatitis. Endoscopy 2015; 47: 605-610
• 606 Lawrence C, Romagnuolo J, Payne KM. et al. Low symptomatic premature stent occlusion of multiple plastic stents for benign biliary strictures: comparing standard and prolonged stent change intervals. Gastrointest Endosc 2010; 72: 558-563
• 607 van der Gaag NA, Rauws EA, van Eijck CH. et al. Preoperative biliary drainage for cancer of the head of the pancreas. N Engl J Med 2010; 362: 129-137
• 608 Bolm L, Petrova E, Woehrmann L. et al. The impact of preoperative biliary stenting in pancreatic cancer: A case-matched study from the German nationwide pancreatic surgery registry (DGAV StuDoQ|Pancreas). Pancreatology 2019; 19: 985-993
• 609 Darnell EP, Wang TJ, Lumish MA. et al. Preoperative cholangitis is an independent risk factor for mortality in patients after pancreatoduodenectomy for pancreatic cancer. Am J Surg 2020;
• 610 De Pastena M, Marchegiani G, Paiella S. et al. Impact of preoperative biliary drainage on postoperative outcome after pancreaticoduodenectomy: An analysis of 1500 consecutive cases. Dig Endosc 2018; 30: 777-784
• 611 Cho JH, Yoon YS, Kim EJ. et al. A multicenter prospective randomized controlled trial for preoperative biliary drainage with uncovered metal versus plastic stents for resectable periampullary cancer. J Hepatobiliary Pancreat Sci 2020;
• 612 Seo DW, Sherman S, Dua KS. et al. Covered and uncovered biliary metal stents provide similar relief of biliary obstruction during neoadjuvant therapy in pancreatic cancer: a randomized trial. Gastrointest Endosc 2019; 90: 602-612.e604
• 613 Jawad ZAR, Kyriakides C, Pai M. et al. Surgery remains the best option for the management of pain in patients with chronic pancreatitis: A systematic review and meta-analysis. Asian journal of surgery 2017; 40: 179-185
• 614 D’Haese JG, Ceyhan GO, Demir IE. et al. Treatment options in painful chronic pancreatitis: a systematic review. HPB (Oxford) 2014; 16: 512-521
• 615 Dite P, Ruzicka M, Zboril V. et al. A prospective, randomized trial comparing endoscopic and surgical therapy for chronic pancreatitis. Endoscopy 2003; 35: 553-558
• 616 Dhar VK, Levinsky NC, Xia BT. et al. The natural history of chronic pancreatitis after operative intervention: The need for revisional operation. Surgery 2016; 160: 977-986
• 617 Seelig MH, Chromik AM, Weyhe D. et al. Pancreatic redo procedures: to do or not to do -- this is the question. J Gastrointest Surg 2007; 11: 1175-1182
• 618 Wilson GC, Sutton JM, Smith MT. et al Completion pancreatectomy and islet cell autotransplantation as salvage therapy for patients failing previous operative interventions for chronic pancreatitis. Surgery 2015; 158: 872-878 ; discussion 879-880
• 619 Bellin MD, Freeman ML, Gelrud A. et al. Total pancreatectomy and islet autotransplantation in chronic pancreatitis: recommendations from PancreasFest. Pancreatology 2014; 14: 27-35
• 620 Hartwig W, Gluth A, Hinz U. et al. Total pancreatectomy for primary pancreatic neoplasms: renaissance of an unpopular operation. Ann Surg 2015; 261: 537-546
• 621 Kleeff J, Stoss C, Mayerle J. et al. Evidence-Based Surgical Treatments for Chronic Pancreatitis. Dtsch Arztebl Int 2016; 113: 489-496
• 622 Bilimoria KY, Bentrem DJ, Ko CY. et al. National failure to operate on early stage pancreatic cancer. Ann Surg 2007; 246: 173-180
• 623 Conroy T, Hammel P, Hebbar M. et al. FOLFIRINOX or Gemcitabine as Adjuvant Therapy for Pancreatic Cancer. N Engl J Med 2018; 379: 2395-2406
• 624 Ahmed Ali U, Issa Y, Bruno MJ. et al. Early surgery versus optimal current step-up practice for chronic pancreatitis (ESCAPE): design and rationale of a randomized trial. BMC Gastroenterol 2013; 13: 49
• 625 Kloppel G. Chronic pancreatitis, pseudotumors and other tumor-like lesions. Mod Pathol 2007; 20 (Suppl. 01) S113-S131
• 626 Zhang L, Chari S, Smyrk TC. et al. Autoimmune pancreatitis (AIP) type 1 and type 2: an international consensus study on histopathologic diagnostic criteria. Pancreas 2011; 40: 1172-1179
• 627 Kahl S, Zimmermann S, Genz I. et al. Risk factors for failure of endoscopic stenting of biliary strictures in chronic pancreatitis: a prospective follow-up study. Am J Gastroenterol 2003; 98: 2448-2453
• 628 Klempa I, Spatny M, Menzel J. et al. Pancreatic function and quality of life after resection of the head of the pancreas in chronic pancreatitis. A prospective, randomized comparative study after duodenum preserving resection of the head of the pancreas versus Whipple’s operation. Chirurg 1995; 66: 350-359
• 629 Büchler MW, Friess H, Müller MW. et al Randomized trial of duodenum-preserving pancreatic head resection versus pylorus-preserving Whipple in chronic pancreatitis. Am J Surg 1995; 169: 65-69 ; discussion 69-70
• 630 Izbicki JR, Bloechle C, Broering DC. et al. Extended drainage versus resection in surgery for chronic pancreatitis: a prospective randomized trial comparing the longitudinal pancreaticojejunostomy combined with local pancreatic head excision with the pylorus-preserving pancreatoduodenectomy. Ann Surg 1998; 228: 771-779
• 631 Farkas G, Leindler L, Daroczi M. et al. Prospective randomised comparison of organ-preserving pancreatic head resection with pylorus-preserving pancreaticoduodenectomy. Langenbecks Arch Surg 2006; 391: 338-342
• 632 Diener MK, Huttner FJ, Kieser M. et al. Partial pancreatoduodenectomy versus duodenum-preserving pancreatic head resection in chronic pancreatitis: the multicentre, randomised, controlled, double-blind ChroPac trial. Lancet 2017; 390: 1027-1037
• 633 Strate T, Taherpour Z, Bloechle C. et al. Long-term follow-up of a randomized trial comparing the beger and frey procedures for patients suffering from chronic pancreatitis. Ann Surg 2005; 241: 591-598
• 634 Köninger J, Seiler CM, Sauerland S. et al. Duodenum-preserving pancreatic head resection--a randomized controlled trial comparing the original Beger procedure with the Berne modification (ISRCTN No. 50638764). Surgery 2008; 143: 490-498
• 635 Duval Jr MK. Caudal pancreaticojejunostomy for chronic pancreatitis; operative criteria and technique. Surg Clin North Am 1956; 831-839
• 636 Partington PF. Chronic pancreatitis treated by Roux type jejunal anastomosis to the biliary tract. AMA archives of surgery 1952; 65: 532-542
• 637 [Anonym]. American Gastroenterological Association Medical Position Statement: treatment of pain in chronic pancreatitis. Gastroenterology 1998; 115: 763-764
• 638 Jimenez RE, Fernandez-Del Castillo C, Rattner DW. et al. Pylorus-preserving pancreaticoduodenectomy in the treatment of chronic pancreatitis. World J Surg 2003; 27: 1211-1216
• 639 Buchler MW, Warshaw AL. Resection versus drainage in treatment of chronic pancreatitis. Gastroenterology 2008; 134: 1605-1607
• 640 Xiao W, Zhu J, Peng L. et al. The role of central pancreatectomy in pancreatic surgery: a systematic review and meta-analysis. HPB (Oxford) 2018; 20: 896-904
• 641 Iacono C, Verlato G, Ruzzenente A. et al. Systematic review of central pancreatectomy and meta-analysis of central versus distal pancreatectomy. Br J Surg 2013; 100: 873-885
• 642 Sheetz KH, Dimick JB, Nathan H. Centralization of High-Risk Cancer Surgery Within Existing Hospital Systems. J Clin Oncol 2019; 37: 3234-3242
• 643 Wellner UF, Grützmann R, Keck T. et al. Quality indicators for pancreatic surgery: Scientific derivation and clinical relevance. Chirurg 2018; 89: 32-39
• 644 Aghdassi AA, Schneider A, Kahl M. et al. Analysis of lifestyle factors in patients with concomitant chronic pancreatitis and liver cirrhosis. Pancreatology 2017; 17: 698-705
• 645 Bang UC, Benfield T, Bendtsen F. et al. The risk of fractures among patients with cirrhosis or chronic pancreatitis. Clin Gastroenterol Hepatol 2014; 12: 320-326
• 646 Bang UC, Benfield T, Hyldstrup L. et al. Mortality, cancer, and comorbidities associated with chronic pancreatitis: a Danish nationwide matched-cohort study. Gastroenterology 2014; 146: 989-994
• 647 Bexelius TS, Ljung R, Mattsson F. et al. Cardiovascular disease and risk of acute pancreatitis in a population-based study. Pancreas 2013; 42: 1011-1015
• 648 Chen CH, Lin CL, Jeng LB. Association between chronic pancreatitis and urolithiasis: A population-based cohort study. PLoS One 2018; 13: e0194019
• 649 Chen YL, Hsu CW, Cheng CC. et al. Increased subsequent risk of inflammatory bowel disease association in patients with chronic pancreatitis: a nationwide population-based cohort study. Curr Med Res Opin 2017; 33: 1077-1082
• 650 Chung WS, Lin CL. Comorbid risks of deep vein thrombosis and pulmonary thromboembolism in patients with chronic pancreatitis: a nationwide cohort study. J Thromb Haemost 2016; 14: 98-104
• 651 Goldacre MJ, Wotton CJ, Yeates D. et al. Liver cirrhosis, other liver diseases, pancreatitis and subsequent cancer: record linkage study. Eur J Gastroenterol Hepatol 2008; 20: 384-392
• 652 Lai SW, Lin CL, Liao KF. Chronic pancreatitis correlates with increased risk of herpes zoster in a population-based retrospective cohort study. J Hepatobiliary Pancreat Sci 2018; 25: 412-417
• 653 Liao KF, Lai SW, Li CI. et al. Diabetes mellitus correlates with increased risk of pancreatic cancer: a population-based cohort study in Taiwan. J Gastroenterol Hepatol 2012; 27: 709-713
• 654 Wang W, Liao Z, Li G. et al. Incidence of pancreatic cancer in chinese patients with chronic pancreatitis. Pancreatology 2011; 11: 16-23
• 655 Dumasy V, Delhaye M, Cotton F. et al. Fat malabsorption screening in chronic pancreatitis. Am J Gastroenterol 2004; 99: 1350-1354
• 656 Ueda J, Tanaka M, Ohtsuka T. et al. Surgery for chronic pancreatitis decreases the risk for pancreatic cancer: a multicenter retrospective analysis. Surgery 2013; 153: 357-364
• 657 Dite P, Hermanova M, Trna J. et al. The role of chronic inflammation: chronic pancreatitis as a risk factor of pancreatic cancer. Dig Dis 2012; 30: 277-283
• 658 Moran CE, Sosa EG, Martinez SM. et al. Bone mineral density in patients with pancreatic insufficiency and steatorrhea. Am J Gastroenterol 1997; 92: 867-871
• 659 Teichmann J, Mann ST, Stracke H. et al. Alterations of vitamin D3 metabolism in young women with various grades of chronic pancreatitis. Eur J Med Res 2007; 12: 347-350
• 660 Lowenfels AB, Maisonneuve P, Cavallini G. et al. Prognosis of chronic pancreatitis: an international multicenter study. International Pancreatitis Study Group. Am J Gastroenterol 1994; 89: 1467-1471
• 661 Lowenfels AB, Sullivan T, Fiorianti J. et al. The epidemiology and impact of pancreatic diseases in the United States. Curr Gastroenterol Rep 2005; 7: 90-95
• 662 Levy P, Milan C, Pignon JP. et al. Mortality factors associated with chronic pancreatitis. Unidimensional and multidimensional analysis of a medical-surgical series of 240 patients. Gastroenterology 1989; 96: 1165-1172
• 663 Seicean A, Tantau M, Grigorescu M. et al. Mortality risk factors in chronic pancreatitis. J Gastrointestin Liver Dis 2006; 15: 21-26
• 664 McWilliams RR, Maisonneuve P, Bamlet WR. et al. Risk Factors for Early-Onset and Very-Early-Onset Pancreatic Adenocarcinoma: A Pancreatic Cancer Case-Control Consortium (PanC4) Analysis. Pancreas 2016; 45: 311-316
• 665 Schnelldorfer T, Lewin DN, Adams DB. Operative management of chronic pancreatitis: longterm results in 372 patients. J Am Coll Surg 2007; 204: 1039-1045 ; discussion 1045-1037
• 666 Muller MW, Friess H, Leitzbach S. et al. Perioperative and follow-up results after central pancreatic head resection (Berne technique) in a consecutive series of patients with chronic pancreatitis. Am J Surg 2008; 196: 364-372
• 667 Koninger J, Seiler CM, Sauerland S. et al. Duodenum-preserving pancreatic head resection--a randomized controlled trial comparing the original Beger procedure with the Berne modification (ISRCTN No. 50638764). Surgery 2008; 143: 490-498
• 668 Pawlik TM, Laheru D, Hruban RH. et al. Evaluating the impact of a single-day multidisciplinary clinic on the management of pancreatic cancer. Ann Surg Oncol 2008; 15: 2081-2088
• 669 Lennon AM, Manos LL, Hruban RH. et al. Role of a multidisciplinary clinic in the management of patients with pancreatic cysts: a single-center cohort study. Ann Surg Oncol 2014; 21: 3668-3674
• 670 Gooiker GA, Lemmens VE, Besselink MG. et al. Impact of centralization of pancreatic cancer surgery on resection rates and survival. Br J Surg 2014; 101: 1000-1005
• 671 Shelton CA, Umapathy C, Stello K. et al. Hereditary Pancreatitis in the United States: Survival and Rates of Pancreatic Cancer. Am J Gastroenterol 2018; 113: 1376
• 672 Hao L, Zeng XP, Xin L. et al. Incidence of and risk factors for pancreatic cancer in chronic pancreatitis: A cohort of 1656 patients. Dig Liver Dis 2017; 49: 1249-1256
• 673 Harinck F, Konings IC, Kluijt I. et al. A multicentre comparative prospective blinded analysis of EUS and MRI for screening of pancreatic cancer in high-risk individuals. Gut 2016; 65: 1505-1513
• 674 Vasen H, Ibrahim I, Ponce CG. et al. Benefit of Surveillance for Pancreatic Cancer in High-Risk Individuals: Outcome of Long-Term Prospective Follow-Up Studies From Three European Expert Centers. J Clin Oncol 2016; 34: 2010-2019
• 675 Bellin MD, Beilman GJ, Sutherland DE. et al. How Durable Is Total Pancreatectomy and Intraportal Islet Cell Transplantation for Treatment of Chronic Pancreatitis?. J Am Coll Surg 2019; 228: 329-339
• 676 Canto MI, Harinck F, Hruban RH. et al. International Cancer of the Pancreas Screening (CAPS) Consortium summit on the management of patients with increased risk for familial pancreatic cancer. Gut 2013; 62: 339-347
• 677 Kandula L, Lowe ME. Etiology and outcome of acute pancreatitis in infants and toddlers. J Pediatr 2008; 152: 106-110 , 110 e101
• 678 Park AJ, Latif SU, Ahmad MU. et al. A comparison of presentation and management trends in acute pancreatitis between infants/toddlers and older children. J Pediatr Gastroenterol Nutr 2010; 51: 167-170
• 679 Antunes H, Nascimento J, Mesquita A. et al. Acute pancreatitis in children: a tertiary hospital report. Scand J Gastroenterol 2014; 49: 642-647
• 680 Patni N, Li X, Adams-Huet B. et al. The prevalence and etiology of extreme hypertriglyceridemia in children: Data from a tertiary children’s hospital. J Clin Lipidol 2018; 12: 305-310
• 681 Randall MM, McDaniels S, Kyle K. et al. Pancreatitis in pre-adolescent children: a 10 year experience in the pediatric emergency department. BMC Emerg Med 2019; 19: 71
• 682 Giri AK, Midha S, Banerjee P. et al. Common Variants in CLDN2 and MORC4 Genes Confer Disease Susceptibility in Patients with Chronic Pancreatitis. PLoS ONE 2016; 11: e0147345
• 683 Broide E, Dotan I, Weiss B. et al. Idiopathic pancreatitis preceding the diagnosis of inflammatory bowel disease is more frequent in pediatric patients. J Pediatr Gastroenterol Nutr 2011; 52: 714-717
• 684 Scheers I, Palermo JJ, Freedman S. et al. Autoimmune Pancreatitis in Children: Characteristic Features, Diagnosis, and Management. Am J Gastroenterol 2017; 112: 1604-1611
• 685 Ludvigsson JF, Montgomery SM, Ekbom A. Risk of pancreatitis in 14000 individuals with celiac disease. Clin Gastroenterol Hepatol 2007; 5: 1347-1353
• 686 de Buys Roessingh AS, de Lagausie P, Baudoin V. et al. Gastrointestinal complications of post-diarrheal hemolytic uremic syndrome. Eur J Pediatr Surg 2007; 17: 328-334
• 687 Witt H, Kage A, Luck W. et al. Alpha1-antitrypsin genotypes in patients with chronic pancreatitis. Scand J Gastroenterol 2002; 37: 356-359
• 688 Rosendahl J, Landt O, Bernadova J. et al. CFTR, SPINK1, CTRC and PRSS1 variants in chronic pancreatitis: is the role of mutated CFTR overestimated?. Gut 2013; 62: 582-592
• 689 De Boeck K, Weren M, Proesmans M. et al. Pancreatitis among patients with cystic fibrosis: correlation with pancreatic status and genotype. Pediatrics 2005; 115: e463-e469
• 690 Gumaste VV, Roditis N, Mehta D. et al. Serum lipase levels in nonpancreatic abdominal pain versus acute pancreatitis. Am J Gastroenterol 1993; 88: 2051-2055
• 691 Masamune A, Kikuta K, Hamada S. et al. Nationwide survey of hereditary pancreatitis in Japan. J Gastroenterol 2018; 53: 152-160
• 692 Keim V, Witt H, Bauer N. et al. The course of genetically determined chronic pancreatitis. JOP 2003; 4: 146-154
• 693 Abu-El-Haija M, Kumar S, Quiros JA. et al. Management of Acute Pancreatitis in the Pediatric Population: A Clinical Report From the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition Pancreas Committee. J Pediatr Gastroenterol Nutr 2018; 66: 159-176
• 694 Coffey MJ, Nightingale S, Ooi CY. Serum lipase as an early predictor of severity in pediatric acute pancreatitis. J Pediatr Gastroenterol Nutr 2013; 56: 602-608
• 695 Tenner S, Baillie J, DeWitt J. et al American College of Gastroenterology guideline: management of acute pancreatitis. Am J Gastroenterol 2013; 108: 1400-1415 ; 1416
• 696 Ventrucci M, Pezzilli R, Naldoni P. et al. Serum pancreatic enzyme behavior during the course of acute pancreatitis. Pancreas 1987; 2: 506-509
• 697 Carrere J, Estevenon JP, Guy-Crotte O. et al. Physiologically elevated concentration of serum trypsin-like immunoreactivity in newborns. Comparison with lipase. Biol Neonate 1986; 49: 113-120
• 698 Cleghorn G, Durie P, Benjamin L. et al. The ontogeny of serum immunoreactive pancreatic lipase and cationic trypsinogen in the premature human infant. Biol Neonate 1988; 53: 10-16
• 699 Keating JP, Lowe ME. Persistent hyperlipasemia caused by macrolipase in an adolescent. J Pediatr 2002; 141: 129-131
• 700 Abu-El-Haija M, Lin TK, Palermo J. Update to the management of pediatric acute pancreatitis: highlighting areas in need of research. J Pediatr Gastroenterol Nutr 2014; 58: 689-693
• 701 Lowe ME, Greer JB. Pancreatitis in children and adolescents. Curr Gastroenterol Rep 2008; 10: 128-135
• 702 Siegel MJ, Martin KW, Worthington JL. Normal and abnormal pancreas in children: US studies. Radiology 1987; 165: 15-18
• 703 Baker ME, Nelson RC, Rosen MP. et al. ACR Appropriateness Criteria(R) acute pancreatitis. Ultrasound Q 2014; 30: 267-273
• 704 American Gastroenterological Association Institute on “Management of Acute Pancreatits” Clinical P, Economics C, Board AGAIG. AGA Institute medical position statement on acute pancreatitis. Gastroenterology 2007; 132: 2019-2021
• 705 Darge K, Anupindi S. Pancreatitis and the role of US, MRCP and ERCP. Pediatr Radiol 2009; 39 (Suppl. 02) S153-S157
• 706 Gariepy CE, Heyman MB, Lowe ME. et al. Causal Evaluation of Acute Recurrent and Chronic Pancreatitis in Children: Consensus From the INSPPIRE Group. J Pediatr Gastroenterol Nutr 2017; 64: 95-103
• 707 Varadarajulu S, Wilcox CM, Eloubeidi MA. Impact of EUS in the evaluation of pancreaticobiliary disorders in children. Gastrointest Endosc 2005; 62: 239-244
• 708 Rebours V, Boutron-Ruault MC, Schnee M. et al. The natural history of hereditary pancreatitis: a national series. Gut 2009; 58: 97-103
• 709 Witt H, Luck W, Becker M. A signal peptide cleavage site mutation in the cationic trypsinogen gene is strongly associated with chronic pancreatitis. Gastroenterology 1999; 117: 7-10
• 710 Durno C, Corey M, Zielenski J. et al. Genotype and phenotype correlations in patients with cystic fibrosis and pancreatitis. Gastroenterology 2002; 123: 1857-1864
• 711 Ooi CY, Dorfman R, Cipolli M. et al. Type of CFTR mutation determines risk of pancreatitis in patients with cystic fibrosis. Gastroenterology 2011; 140: 153-161
• 712 Audrezet MP, Chen JM, Le Marechal C. et al. Determination of the relative contribution of three genes-the cystic fibrosis transmembrane conductance regulator gene, the cationic trypsinogen gene, and the pancreatic secretory trypsin inhibitor gene-to the etiology of idiopathic chronic pancreatitis. Eur J Hum Genet 2002; 10: 100-106
• 713 Cohn JA, Neoptolemos JP, Feng J. et al. Increased risk of idiopathic chronic pancreatitis in cystic fibrosis carriers. Hum Mutat 2005; 26: 303-307
• 714 LaRusch J, Jung J, General IJ. et al. Mechanisms of CFTR functional variants that impair regulated bicarbonate permeation and increase risk for pancreatitis but not for cystic fibrosis. PLoS Genet 2014; 10: e1004376
• 715 Szabo FK, Fei L, Cruz LA. et al. Early Enteral Nutrition and Aggressive Fluid Resuscitation are Associated with Improved Clinical Outcomes in Acute Pancreatitis. J Pediatr 2015; 167: 397-402 e391
• 716 Cheng CL, Fogel EL, Sherman S. et al. Diagnostic and therapeutic endoscopic retrograde cholangiopancreatography in children: a large series report. J Pediatr Gastroenterol Nutr 2005; 41: 445-453
• 717 Enestvedt BK, Tofani C, Lee DY. et al. Endoscopic retrograde cholangiopancreatography in the pediatric population is safe and efficacious. J Pediatr Gastroenterol Nutr 2013; 57: 649-654
• 718 Giefer MJ, Kozarek RA. Technical outcomes and complications of pediatric ERCP. Surg Endosc 2015; 29: 3543-3550
• 719 Limketkai BN, Chandrasekhara V, Kalloo AN. et al. Comparison of performance and safety of endoscopic retrograde cholangiopancreatography across pediatric age groups. Dig Dis Sci 2013; 58: 2653-2660
• 720 Paris C, Bejjani J, Beaunoyer M. et al. Endoscopic retrograde cholangiopancreatography is useful and safe in children. J Pediatr Surg 2010; 45: 938-942
• 721 Troendle DM, Barth BA. ERCP can be safely and effectively performed by a pediatric gastroenterologist for choledocholithiasis in a pediatric facility. J Pediatr Gastroenterol Nutr 2013; 57: 655-658
• 722 Usatin D, Fernandes M, Allen IE. et al. Complications of Endoscopic Retrograde Cholangiopancreatography in Pediatric Patients; A Systematic Literature Review and Meta-Analysis. J Pediatr 2016; 179: 160-165 e163
• 723 Vegting IL, Tabbers MM, Taminiau JAJM. et al. Is endoscopic retrograde cholangiopancreatography valuable and safe in children of all ages?. J Pediatr Gastroenterol Nutr 2009; 48: 66-71
• 724 Weber TR, Keller MS. Operative management of chronic pancreatitis in children. Arch Surg 2001; 136: 550-554
• 725 Chiu B, Lopoo J, Superina RA. Longitudinal pancreaticojejunostomy and selective biliary diversion for chronic pancreatitis in children. J Pediatr Surg 2006; 41: 946-949
• 726 Laje P, Adzick NS. Modified Puestow procedure for the management of chronic pancreatitis in children. J Pediatr Surg 2013; 48: 2271-2275
• 727 Chromik AM, Seelig MH, Saewe B. et al. Tailored resective pancreatic surgery for pediatric patients with chronic pancreatitis. J Pediatr Surg 2008; 43: 634-643
• 728 Bellin MD, Forlenza GP, Majumder K. et al. Total Pancreatectomy With Islet Autotransplantation Resolves Pain in Young Children With Severe Chronic Pancreatitis. J Pediatr Gastroenterol Nutr 2017; 64: 440-445
• 729 Dzakovic A, Superina R. Acute and chronic pancreatitis: surgical management. Semin Pediatr Surg 2012; 21: 266-271
• 730 Werlin SL, Kugathasan S, Frautschy BC. Pancreatitis in children. J Pediatr Gastroenterol Nutr 2003; 37: 591-595
• 731 Morinville VD, Husain SZ, Bai H. et al. Definitions of pediatric pancreatitis and survey of present clinical practices. J Pediatr Gastroenterol Nutr 2012; 55: 261-265
• 732 Abu-El-Haija M, Wilhelm R, Heinzman C. et al. Early Enteral Nutrition in Children With Acute Pancreatitis. J Pediatr Gastroenterol Nutr 2016; 62: 453-456
• 733 Abu-El-Haija M, Uc A, Werlin SL. et al. Nutritional Considerations in Pediatric Pancreatitis: A Position Paper from the NASPGHAN Pancreas Committee and ESPGHAN Cystic Fibrosis/Pancreas Working Group. J Pediatr Gastroenterol Nutr 2018; 67: 131-143
• 734 Borowitz DS, Grand RJ, Durie PR. Use of pancreatic enzyme supplements for patients with cystic fibrosis in the context of fibrosing colonopathy. Consensus Committee. J Pediatr 1995; 127: 681-684
• 735 Stallings VA, Stark LJ, Robinson KA. et al. Evidence-based practice recommendations for nutrition-related management of children and adults with cystic fibrosis and pancreatic insufficiency: results of a systematic review. J Am Diet Assoc 2008; 108: 832-839
• 736 Carroccio A, Pardo F, Montalto G. et al. Use of famotidine in severe exocrine pancreatic insufficiency with persistent maldigestion on enzymatic replacement therapy. A long-term study in cystic fibrosis. Dig Dis Sci 1992; 37: 1441-1446
• 737 DiMagno EP. Gastric acid suppression and treatment of severe exocrine pancreatic insufficiency. Best Pract Res Clin Gastroenterol 2001; 15: 477-486
• 738 Graff GR, Maguiness K, McNamara J. et al. Efficacy and tolerability of a new formulation of pancrelipase delayed-release capsules in children aged 7 to 11 years with exocrine pancreatic insufficiency and cystic fibrosis: a multicenter, randomized, double-blind, placebo-controlled, two-period crossover, superiority study. Clin Ther 2010; 32: 89-103
• 739 Griese M, Dokupil K, Latzin P. Skin prick test reactivity to supplemental enzymes in cystic fibrosis and pancreatic insufficiency. J Pediatr Gastroenterol Nutr 2005; 40: 194-198
• 740 Afghani E, Sinha A, Singh VK. An overview of the diagnosis and management of nutrition in chronic pancreatitis. Nutr Clin Pract 2014; 29: 295-311
• 741 Dickerson RN, Vehe KL, Mullen JL. et al. Resting energy expenditure in patients with pancreatitis. Crit Care Med 1991; 19: 484-490
• 742 Rasmussen HH, Irtun O, Olesen SS. et al. Nutrition in chronic pancreatitis. World J Gastroenterol 2013; 19: 7267-7275
• 743 Duggan SN, Smyth ND, O’Sullivan M. et al. The prevalence of malnutrition and fat-soluble vitamin deficiencies in chronic pancreatitis. Nutr Clin Pract 2014; 29: 348-354
• 744 Funakoshi A, Kimura T, Shinozaki H. et al. Comparisons between absorption of vitamin E in patients with chronic pancreatitis and healthy controls: the bioavailability of vitamin E. Tohoku J Exp Med 1986; 148: 393-401
• 745 Klapdor S, Richter E, Klapdor R. Vitamin D status and per-oral vitamin D supplementation in patients suffering from chronic pancreatitis and pancreatic cancer disease. Anticancer Res 2012; 32: 1991-1998
• 746 Bowrey DJ, Morris-Stiff GJ, Puntis MC. Selenium deficiency and chronic pancreatitis: disease mechanism and potential for therapy. HPB Surg 1999; 11: 207-215 ; discussion 215-206
• 747 Morris-Stiff GJ, Bowrey DJ, Oleesky D. et al. The antioxidant profiles of patients with recurrent acute and chronic pancreatitis. Am J Gastroenterol 1999; 94: 2135-2140
• 748 Vujasinovic M, Hedstrom A, Maisonneuve P. et al. Zinc deficiency in patients with chronic pancreatitis. World J Gastroenterol 2019; 25: 600-607
• 749 Mathew P, Wyllie R, Van Lente F. et al. Antioxidants in hereditary pancreatitis. Am J Gastroenterol 1996; 91: 1558-1562
• 750 Shimosegawa T, Chari ST, Frulloni L. et al. International consensus diagnostic criteria for autoimmune pancreatitis: guidelines of the International Association of Pancreatology. Pancreas 2011; 40: 352-358
• 751 Song TJ, Kim MH, Kim MJ. et al. Clinical validation of the international consensus diagnostic criteria and algorithms for autoimmune pancreatitis: combined IAP and KPBA meeting 2013 report. Pancreatology 2014; 14: 233-237
• 752 Schneider A, Michaely H, Ruckert F. et al. Diagnosing autoimmune pancreatitis with the Unifying-Autoimmune-Pancreatitis-Criteria. Pancreatology 2017; 17: 381-394
• 753 Hirth M, Vujasinovic M, Munch M. et al. Monitoring and predicting disease activity in autoimmune pancreatitis with the M-ANNHEIM-AiP-Activity-Score. Pancreatology 2018; 18: 29-38
• 754 Hart PA, Kamisawa T, Brugge WR. et al. Long-term outcomes of autoimmune pancreatitis: a multicentre, international analysis. Gut 2013; 62: 1771-1776
• 755 Frulloni L, Scattolini C, Katsotourchi AM. et al. Exocrine and endocrine pancreatic function in 21 patients suffering from autoimmune pancreatitis before and after steroid treatment. Pancreatology 2010; 10: 129-133
• 756 Vujasinovic M, Valente R, Maier P. et al. Diagnosis, treatment and long-term outcome of autoimmune pancreatitis in Sweden. Pancreatology 2018; 18: 900-904
• 757 Pickartz T, Mayerle J, Lerch MM. Autoimmune pancreatitis. Nat Clin Pract Gastroenterol Hepatol 2007; 4: 314-323
• 758 Okazaki K, Chari ST, Frulloni L. et al. International consensus for the treatment of autoimmune pancreatitis. Pancreatology 2017; 17: 1-6
• 759 Ghazale A, Chari ST, Smyrk TC. et al. Value of serum IgG4 in the diagnosis of autoimmune pancreatitis and in distinguishing it from pancreatic cancer. Am J Gastroenterol 2007; 102: 1646-1653
• 760 Schneider A, Hirth M, Munch M. et al. Risk of Cancer in Patients with Autoimmune Pancreatitis: A Single-Center Experience from Germany. Digestion 2017; 95: 172-180
• 761 Wallace ZS, Zhang Y, Perugino CA. et al. Clinical phenotypes of IgG4-related disease: an analysis of two international cross-sectional cohorts. Ann Rheum Dis 2019; 78: 406-412
• 762 Kawa S, Okazaki K, Kamisawa T. et al. Amendment of the Japanese Consensus Guidelines for Autoimmune Pancreatitis, 2013 II. Extrapancreatic lesions, differential diagnosis. J Gastroenterol 2014; 49: 765-784
• 763 Vujasinovic M, Pozzi Mucelli RM, Valente R. et al. Kidney Involvement in Patients with Type 1 Autoimmune Pancreatitis. Journal of clinical medicine 2019; 8: 258
• 764 Chari ST, Kloeppel G, Zhang L. et al. Histopathologic and clinical subtypes of autoimmune pancreatitis: the Honolulu consensus document. Pancreas 2010; 39: 549-554
• 765 Chari ST, Smyrk TC, Levy MJ. et al Diagnosis of autoimmune pancreatitis: the Mayo Clinic experience. Clin Gastroenterol Hepatol 2006; 4: 1010-1016 ; quiz 1934
• 766 Raina A, Yadav D, Krasinskas AM. et al. Evaluation and management of autoimmune pancreatitis: experience at a large US center. Am J Gastroenterol 2009; 104: 2295-2306
• 767 van Heerde MJ, Buijs J, Rauws EA. et al. A comparative study of diagnostic scoring systems for autoimmune pancreatitis. Pancreas 2014; 43: 559-564
• 768 Moon SH, Kim MH, Park DH. et al. Is a 2-week steroid trial after initial negative investigation for malignancy useful in differentiating autoimmune pancreatitis from pancreatic cancer? A prospective outcome study. Gut 2008; 57: 1704-1712
• 769 Bang SJ, Kim MH, Kim DH. et al. Is pancreatic core biopsy sufficient to diagnose autoimmune chronic pancreatitis?. Pancreas 2008; 36: 84-89
• 770 Hirano K, Fukushima N, Tada M. et al. Diagnostic utility of biopsy specimens for autoimmune pancreatitis. J Gastroenterol 2009; 44: 765-773
• 771 Jung JG, Lee JK, Lee KH. et al. Comparison of endoscopic retrograde cholangiopancreatography with papillary biopsy and endoscopic ultrasound-guided pancreatic biopsy in the diagnosis of autoimmune pancreatitis. Pancreatology 2015; 15: 259-264
• 772 Kamisawa T, Tu Y, Egawa N. et al. A new diagnostic endoscopic tool for autoimmune pancreatitis. Gastrointest Endosc 2008; 68: 358-361
• 773 Frulloni L, Scattolini C, Falconi M. et al. Autoimmune pancreatitis: differences between the focal and diffuse forms in 87 patients. Am J Gastroenterol 2009; 104: 2288-2294
• 774 Ohara H, Nakazawa T, Sano H. et al. Systemic extrapancreatic lesions associated with autoimmune pancreatitis. Pancreas 2005; 31: 232-237
• 775 Okazaki K, Kawa S, Kamisawa T. et al. Clinical diagnostic criteria of autoimmune pancreatitis: revised proposal. J Gastroenterol 2006; 41: 626-631
• 776 Pearson RK, Longnecker DS, Chari ST. et al. Controversies in clinical pancreatology: autoimmune pancreatitis: does it exist?. Pancreas 2003; 27: 1-13
• 777 Yoshida K, Toki F, Takeuchi T. et al. Chronic pancreatitis caused by an autoimmune abnormality. Proposal of the concept of autoimmune pancreatitis. Dig Dis Sci 1995; 40: 1561-1568
• 778 Kamisawa T, Egawa N, Nakajima H. Autoimmune pancreatitis is a systemic autoimmune disease. Am J Gastroenterol 2003; 98: 2811-2812
• 779 Kamisawa T, Funata N, Hayashi Y. et al. Close relationship between autoimmune pancreatitis and multifocal fibrosclerosis. Gut 2003; 52: 683-687
• 780 Kamisawa T, Chari ST, Lerch MM. et al. Recent advances in autoimmune pancreatitis: type 1 and type 2. Gut 2013; 62: 1373-1380
• 781 Aparisi L, Farre A, Gomez-Cambronero L. et al. Antibodies to carbonic anhydrase and IgG4 levels in idiopathic chronic pancreatitis: relevance for diagnosis of autoimmune pancreatitis. Gut 2005; 54: 703-709
• 782 Detlefsen S, de Vos JD, Tanassi JT. et al. Value of anti-plasminogen binding peptide, anti-carbonic anhydrase II, immunoglobulin G4, and other serological markers for the differentiation of autoimmune pancreatitis and pancreatic cancer. Medicine (Baltimore) 2018; 97: e11641
• 783 Lohr JM, Faissner R, Koczan D. et al. Autoantibodies against the exocrine pancreas in autoimmune pancreatitis: gene and protein expression profiling and immunoassays identify pancreatic enzymes as a major target of the inflammatory process. Am J Gastroenterol 2010; 105: 2060-2071
• 784 Nishimori I, Miyaji E, Morimoto K. et al. Serum antibodies to carbonic anhydrase IV in patients with autoimmune pancreatitis. Gut 2005; 54: 274-281
• 785 Okazaki K, Uchida K, Ohana M. et al. Autoimmune-related pancreatitis is associated with autoantibodies and a Th1 / Th2-type cellular immune response. Gastroenterology 2000; 118: 573-581
• 786 Smyk DS, Rigopoulou EI, Koutsoumpas AL. et al. Autoantibodies in autoimmune pancreatitis. International journal of rheumatology 2012; 2012: 940831
• 787 Kim KP, Kim MH, Kim JC. et al. Diagnostic criteria for autoimmune chronic pancreatitis revisited. World J Gastroenterol 2006; 12: 2487-2496
• 788 Furuhashi N, Suzuki K, Sakurai Y. et al. Differentiation of focal-type autoimmune pancreatitis from pancreatic carcinoma: assessment by multiphase contrast-enhanced CT. Eur Radiol 2015; 25: 1366-1374
• 789 Klauss M, Maier-Hein K, Tjaden C. et al. IVIM DW-MRI of autoimmune pancreatitis: therapy monitoring and differentiation from pancreatic cancer. Eur Radiol 2016; 26: 2099-2106
• 790 Manfredi R, Frulloni L, Mantovani W. et al. Autoimmune pancreatitis: pancreatic and extrapancreatic MR imaging-MR cholangiopancreatography findings at diagnosis, after steroid therapy, and at recurrence. Radiology 2011; 260: 428-436
• 791 Negrelli R, Manfredi R, Pedrinolla B. et al. Pancreatic duct abnormalities in focal autoimmune pancreatitis: MR/MRCP imaging findings. Eur Radiol 2015; 25: 359-367
• 792 Rehnitz C, Klauss M, Singer R. et al. Morphologic patterns of autoimmune pancreatitis in CT and MRI. Pancreatology 2011; 11: 240-251
• 793 Sugumar A, Levy MJ, Kamisawa T. et al. Endoscopic retrograde pancreatography criteria to diagnose autoimmune pancreatitis: an international multicentre study. Gut 2011; 60: 666-670
• 794 Grenacher L. [Hepatopancreaticobiliary diseases in IgG4-associated autoimmune diseases]. Radiologe 2016; 56: 1052-1060
• 795 Kim HJ, Kim YK, Jeong WK. et al. Pancreatic duct “Icicle sign” on MRI for distinguishing autoimmune pancreatitis from pancreatic ductal adenocarcinoma in the proximal pancreas. Eur Radiol 2015; 25: 1551-1560
• 796 Suzuki K, Itoh S, Nagasaka T. et al. CT findings in autoimmune pancreatitis: assessment using multiphase contrast-enhanced multisection CT. Clin Radiol 2010; 65: 735-743
• 797 Detlefsen S, Mohr Drewes A, Vyberg M. et al. Diagnosis of autoimmune pancreatitis by core needle biopsy: application of six microscopic criteria. Virchows Archiv: an international journal of pathology 2009; 454: 531-539
• 798 Kanno A, Masamune A, Fujishima F. et al. Diagnosis of autoimmune pancreatitis by EUS-guided FNA using a 22-gauge needle: a prospective multicenter study. Gastrointest Endosc 2016; 84: 797-804 e791
• 799 Kurita A, Yasukawa S, Zen Y. et al. Comparison of a 22-gauge Franseen-tip needle with a 20-gauge forward-bevel needle for the diagnosis of type 1 autoimmune pancreatitis: a prospective, randomized, controlled, multicenter study (COMPAS study). Gastrointest Endosc 2020; 91: 373-381 e372
• 800 Morishima T, Kawashima H, Ohno E. et al. Prospective multicenter study on the usefulness of EUS-guided FNA biopsy for the diagnosis of autoimmune pancreatitis. Gastrointest Endosc 2016; 84: 241-248
• 801 Chari ST, Takahashi N, Levy MJ. et al. A diagnostic strategy to distinguish autoimmune pancreatitis from pancreatic cancer. Clin Gastroenterol Hepatol 2009; 7: 1097-1103
• 802 Buijs J, van Heerde MJ, Rauws EA. et al. Comparable efficacy of low- versus high-dose induction corticosteroid treatment in autoimmune pancreatitis. Pancreas 2014; 43: 261-267
• 803 Buijs J, Cahen DL, van Heerde MJ. et al. The Long-Term Impact of Autoimmune Pancreatitis on Pancreatic Function, Quality of Life, and Life Expectancy. Pancreas 2015; 44: 1065-1071
• 804 Maire F, Le Baleur Y, Rebours V. et al. Outcome of patients with type 1 or 2 autoimmune pancreatitis. Am J Gastroenterol 2011; 106: 151-156
• 805 Sah RP, Chari ST, Pannala R. et al Differences in clinical profile and relapse rate of type 1 versus type 2 autoimmune pancreatitis. Gastroenterology 2010; 139: 140-148 ; quiz e112-143
• 806 Bi Y, Hart PA, Law R. et al. Obstructive jaundice in autoimmune pancreatitis can be safely treated with corticosteroids alone without biliary stenting. Pancreatology 2016; 16: 391-396
• 807 Church NI, Pereira SP, Deheragoda MG. et al. Autoimmune pancreatitis: clinical and radiological features and objective response to steroid therapy in a UK series. Am J Gastroenterol 2007; 102: 2417-2425
• 808 Goyal J, Barkin JA, Barkin JS. Randomised controlled trial of long-term maintenance corticosteroid therapy in patients with autoimmune pancreatitis. Gut 2018; 67: 591
• 809 Hart PA, Topazian MD, Witzig TE. et al. Treatment of relapsing autoimmune pancreatitis with immunomodulators and rituximab: the Mayo Clinic experience. Gut 2013; 62: 1607-1615
• 810 Hirano K, Tada M, Isayama H. et al. Outcome of Long-term Maintenance Steroid Therapy Cessation in Patients With Autoimmune Pancreatitis: A Prospective Study. J Clin Gastroenterol 2016; 50: 331-337
• 811 Ito T, Nishimori I, Inoue N. et al. Treatment for autoimmune pancreatitis: consensus on the treatment for patients with autoimmune pancreatitis in Japan. J Gastroenterol 2007; 42 (Suppl. 18) 50-58
• 812 Kamisawa T, Shimosegawa T, Okazaki K. et al. Standard steroid treatment for autoimmune pancreatitis. Gut 2009; 58: 1504-1507
• 813 Matsushita M, Yamashina M, Ikeura T. et al. Effective steroid pulse therapy for the biliary stenosis caused by autoimmune pancreatitis. Am J Gastroenterol 2007; 102: 220-221
• 814 Sahani DV, Kalva SP, Farrell J. et al. Autoimmune pancreatitis: imaging features. Radiology 2004; 233: 345-352
• 815 Yukutake M, Sasaki T, Serikawa M. et al. Timing of radiological improvement after steroid therapy in patients with autoimmune pancreatitis. Scand J Gastroenterol 2014; 49: 727-733
• 816 Kamisawa T, Anjiki H, Takuma K. et al. The natural course of autoimmune pancreatitis. Hepatogastroenterology 2009; 56: 866-870
• 817 Kamisawa T, Okazaki K, Kawa S. et al. Amendment of the Japanese Consensus Guidelines for Autoimmune Pancreatitis, 2013 III. Treatment and prognosis of autoimmune pancreatitis. J Gastroenterol 2014; 49: 961-970
• 818 Kamisawa T, Yoshiike M, Egawa N. et al Treating patients with autoimmune pancreatitis: results from a long-term follow-up study. Pancreatology 2005; 5: 234-238 ; discussion 238-240
• 819 Nishimori I, Tamakoshi A, Kawa S. et al. Influence of steroid therapy on the course of diabetes mellitus in patients with autoimmune pancreatitis: findings from a nationwide survey in Japan. Pancreas 2006; 32: 244-248
• 820 Kubota K, Iida H, Fujisawa T. et al. Clinical factors predictive of spontaneous remission or relapse in cases of autoimmune pancreatitis. Gastrointest Endosc 2007; 66: 1142-1151
• 821 Hirano K, Tada M, Isayama H. et al. Long-term prognosis of autoimmune pancreatitis with and without corticosteroid treatment. Gut 2007; 56: 1719-1724
• 822 Soliman H, Vullierme MP, Maire F. et al. Risk factors and treatment of relapses in autoimmune pancreatitis: Rituximab is safe and effective. United European Gastroenterol J 2019; 7: 1073-1083
• 823 Carruthers MN, Khosroshahi A, Augustin T. et al. The diagnostic utility of serum IgG4 concentrations in IgG4-related disease. Ann Rheum Dis 2015; 74: 14-18
• 824 Masamune A, Nishimori I, Kikuta K. et al. Randomised controlled trial of long-term maintenance corticosteroid therapy in patients with autoimmune pancreatitis. Gut 2017; 66: 487-494
• 825 Wallace ZS, Mattoo H, Carruthers M. et al. Plasmablasts as a biomarker for IgG4-related disease, independent of serum IgG4 concentrations. Ann Rheum Dis 2015; 74: 190-195
• 826 Carruthers MN, Topazian MD, Khosroshahi A. et al. Rituximab for IgG4-related disease: a prospective, open-label trial. Ann Rheum Dis 2015; 74: 1171-1177
• 827 Maertens J, Cesaro S, Maschmeyer G. et al. ECIL guidelines for preventing Pneumocystis jirovecii pneumonia in patients with haematological malignancies and stem cell transplant recipients. The Journal of antimicrobial chemotherapy 2016; 71: 2397-2404
• 828 Clark CJ, Morales-Oyarvide V, Zaydfudim V. et al. Short-term and long-term outcomes for patients with autoimmune pancreatitis after pancreatectomy: a multi-institutional study. J Gastrointest Surg 2013; 17: 899-906
• 829 van Heerde MJ, Biermann K, Zondervan PE. et al. Prevalence of autoimmune pancreatitis and other benign disorders in pancreatoduodenectomy for presumed malignancy of the pancreatic head. Dig Dis Sci 2012; 57: 2458-2465
• 830 Lohr JM, Dominguez-Munoz E, Rosendahl J. et al. United European Gastroenterology evidence-based guidelines for the diagnosis and therapy of chronic pancreatitis (HaPanEU). United European Gastroenterol J 2017; 5: 153-199
• 831 Okazaki K, Kawa S, Kamisawa T. et al. Amendment of the Japanese Consensus Guidelines for Autoimmune Pancreatitis, 2013 I. Concept and diagnosis of autoimmune pancreatitis. J Gastroenterol 2014; 49: 567-588
• 832 Duggan SN, Smyth ND, Murphy A. et al. High prevalence of osteoporosis in patients with chronic pancreatitis: a systematic review and meta-analysis. Clin Gastroenterol Hepatol 2014; 12: 219-228
• 833 Ito T, Kawa S, Matsumoto A. et al. Risk Factors for Pancreatic Stone Formation in Type 1 Autoimmune Pancreatitis: A Long-term Japanese Multicenter Analysis of 624 Patients. Pancreas 2019; 48: 49-54
• 834 Maruyama M, Arakura N, Ozaki Y. et al. Type 1 autoimmune pancreatitis can transform into chronic pancreatitis: a long-term follow-up study of 73 Japanese patients. International journal of rheumatology 2013; 2013: 272595
• 835 Asano J, Watanabe T, Oguchi T. et al. Association Between Immunoglobulin G4-related Disease and Malignancy within 12 Years after Diagnosis: An Analysis after Longterm Followup. The Journal of rheumatology 2015; 42: 2135-2142
• 836 Gupta R, Khosroshahi A, Shinagare S. et al. Does autoimmune pancreatitis increase the risk of pancreatic carcinoma?: a retrospective analysis of pancreatic resections. Pancreas 2013; 42: 506-510
• 837 Hart PA, Law RJ, Dierkhising RA. et al. Risk of cancer in autoimmune pancreatitis: a case-control study and review of the literature. Pancreas 2014; 43: 417-421
• 838 Hirano K, Tada M, Sasahira N. et al. Incidence of malignancies in patients with IgG4-related disease. Intern Med 2014; 53: 171-176
• 839 Ikeura T, Miyoshi H, Uchida K. et al. Relationship between autoimmune pancreatitis and pancreatic cancer: a single-center experience. Pancreatology 2014; 14: 373-379
• 840 Kamisawa T, Tsuruta K, Okamoto A. et al. Frequent and significant K-ras mutation in the pancreas, the bile duct, and the gallbladder in autoimmune pancreatitis. Pancreas 2009; 38: 890-895
• 841 Shiokawa M, Kodama Y, Yoshimura K. et al. Risk of cancer in patients with autoimmune pancreatitis. Am J Gastroenterol 2013; 108: 610-617
• 842 Ahn SS, Song JJ, Park YB. et al. Malignancies in Korean patients with immunoglobulin G4-related disease. International journal of rheumatic diseases 2017; 20: 1028-1035
• 843 Wallace ZS, Wallace CJ, Lu N. et al. Association of IgG4-related disease with history of malignancy. Arthritis Rheumatol 2016; 68: 2283-2289
• 844 Yamamoto M, Takahashi H, Tabeya T. et al. Risk of malignancies in IgG4-related disease. Mod Rheumatol 2012; 22: 414-418
• 845 Huggett MT, Culver EL, Kumar M. et al. Type 1 autoimmune pancreatitis and IgG4-related sclerosing cholangitis is associated with extrapancreatic organ failure, malignancy, and mortality in a prospective UK cohort. Am J Gastroenterol 2014; 109: 1675-1683
• 846 Detlefsen S, Zamboni G, Frulloni L. et al. Clinical features and relapse rates after surgery in type 1 autoimmune pancreatitis differ from type 2: a study of 114 surgically treated European patients. Pancreatology 2012; 12: 276-283
• 847 Lopez-Serrano A, Crespo J, Pascual I. et al. Diagnosis, treatment and long-term outcomes of autoimmune pancreatitis in Spain based on the International Consensus Diagnostic Criteria: A multi-centre study. Pancreatology 2016; 16: 382-390
• 848 Rasch S, Phillip V, Schmid RM. et al. Epidemiology, clinical presentation, diagnosis and treatment of autoimmune pancreatitis: A retrospective analysis of 53 patients. Pancreatology 2016; 16: 73-77
• 849 Kanno A, Nishimori I, Masamune A. et al. Nationwide epidemiological survey of autoimmune pancreatitis in Japan. Pancreas 2012; 41: 835-839
• 850 Park SH, Kim D, Ye BD. et al. The characteristics of ulcerative colitis associated with autoimmune pancreatitis. J Clin Gastroenterol 2013; 47: 520-525
• 851 Ravi K, Chari ST, Vege SS. et al. Inflammatory bowel disease in the setting of autoimmune pancreatitis. Inflammatory bowel diseases 2009; 15: 1326-1330
• 852 Schneider A, Hirth M, Weiss C. et al. Prevalence of inflammatory bowel disease in alcoholic, non-alcoholic and autoimmune pancreatitis. Z Gastroenterol 2018; 56: 469-478