Nuklearmedizin 2021; 60(05): 326-343
DOI: 10.1055/a-1525-7029
Review

Value of PET imaging for radiation therapy[*]

Wertigkeit der PET-Bildgebung für die Radioonkologie

Authors

  • Constantin Lapa

    1   Nuclear Medicine, Medical Faculty, University of Augsburg, Augsburg, Germany
  • Ursula Nestle

    2   Department of Radiation Oncology, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany
    3   German Cancer Consortium (DKTK), Partner Site Freiburg, Freiburg, Germany
    4   Department of Radiation Oncology, Kliniken Maria Hilf, Mönchengladbach, Germany
  • Nathalie L. Albert

    5   Department of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany
  • Christian Baues

    6   Department of Radiation Oncology, Cyberknife and Radiotherapy, Medical Faculty, University Hospital Cologne, Cologne, Germany
  • Ambros Beer

    7   Department of Nuclear Medicine, Ulm University Hospital, Ulm, Germany
  • Andreas Buck

    8   Department of Nuclear Medicine, University Hospital Würzburg, Würzburg, Germany
  • Volker Budach

    9   Department of Radiation Oncology, Charité-Universitätsmedizin Berlin, Campus Virchow-Klinikum, Berlin, Germany
  • Rebecca Bütof

    10   Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
    11   OncoRay – National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany
  • Stephanie E. Combs

    12   German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany
    13   Department of Radiation Oncology, Technical University of Munich (TUM), Klinikum rechts der Isar, Munich, Germany
    14   Department of Radiation Sciences (DRS), Institute of Radiation Medicine (IRM), Neuherberg, Germany
  • Thorsten Derlin

    15   Department of Nuclear Medicine, Hannover Medical School, Germany
  • Matthias Eiber

    16   Department of Nuclear Medicine, Technical University of Munich (TUM), Klinikum rechts der Isar, Munich, Germany
  • Wolfgang P. Fendler

    17   Department of Nuclear Medicine, University of Duisburg-Essen and German Cancer Consortium (DKTK)-University Hospital Essen, Essen, Germany
  • Christian Furth

    18   Department of Nuclear Medicine, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany
  • Cihan Gani

    19   German Cancer Consortium (DKTK), Partner Site Tübingen, and German Cancer Research Center (DKFZ), Heidelberg, Germany
    20   Department of Radiation Oncology, University of Tübingen, Tübingen, Germany
  • Eleni Gkika

    2   Department of Radiation Oncology, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany
  • Anca L. Grosu

    2   Department of Radiation Oncology, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany
    3   German Cancer Consortium (DKTK), Partner Site Freiburg, Freiburg, Germany
  • Christoph Henkenberens

    21   Department of Radiotherapy and Special Oncology, Medical School Hannover, Germany
  • Harun Ilhan

    5   Department of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany
  • Steffen Löck

    10   Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
    11   OncoRay – National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany
  • Simone Marnitz-Schulze

    6   Department of Radiation Oncology, Cyberknife and Radiotherapy, Medical Faculty, University Hospital Cologne, Cologne, Germany
  • Matthias Miederer

    22   Department of Nuclear Medicine, University Hospital Mainz, Mainz, Germany
  • Michael Mix

    23   Department of Nuclear Medicine, Faculty of Medicine, Medical Center, University of Freiburg, Freiburg, Germany
  • Nils H. Nicolay

    2   Department of Radiation Oncology, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany
    3   German Cancer Consortium (DKTK), Partner Site Freiburg, Freiburg, Germany
  • Maximilian Niyazi

    5   Department of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany
    12   German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany
  • Christoph Pöttgen

    24   Department of Radiation Oncology, West German Cancer Centre, University of Duisburg-Essen, Essen, Germany
  • Claus M. Rödel

    25   German Cancer Consortium (DKTK), Partner Site Frankfurt, and German Cancer Research Center (DKFZ), Heidelberg, Germany
    26   Department of Radiotherapy and Oncology, Goethe University Frankfurt, Frankfurt, Germany
  • Imke Schatka

    18   Department of Nuclear Medicine, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany
  • Sarah M. Schwarzenboeck

    27   Department of Nuclear Medicine, Rostock University Medical Centre, Rostock, Germany
  • Andrei S. Todica

    5   Department of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany
  • Wolfgang Weber

    16   Department of Nuclear Medicine, Technical University of Munich (TUM), Klinikum rechts der Isar, Munich, Germany
  • Simone Wegen

    6   Department of Radiation Oncology, Cyberknife and Radiotherapy, Medical Faculty, University Hospital Cologne, Cologne, Germany
  • Thomas Wiegel

    28   Department of Radiation Oncology, Ulm University Hospital, Ulm, Germany
  • Constantinos Zamboglou

    2   Department of Radiation Oncology, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany
    3   German Cancer Consortium (DKTK), Partner Site Freiburg, Freiburg, Germany
  • Daniel Zips

    19   German Cancer Consortium (DKTK), Partner Site Tübingen, and German Cancer Research Center (DKFZ), Heidelberg, Germany
    20   Department of Radiation Oncology, University of Tübingen, Tübingen, Germany
  • Klaus Zöphel

    11   OncoRay – National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany
    29   National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany
    30   German Cancer Consortium (DKTK), Partner Site Dresden, and German Cancer Research Center (DKFZ), Heidelberg, Germany
    31   Department of Nuclear Medicine, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
    32   Department of Nuclear Medicine, Klinikum Chemnitz gGmbH, Chemnitz, Germany
  • Sebastian Zschaeck

    33   Department of Radiation Oncology, Charité-Universitätsmedizin Berlin, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany
  • Daniela Thorwarth

    19   German Cancer Consortium (DKTK), Partner Site Tübingen, and German Cancer Research Center (DKFZ), Heidelberg, Germany
    34   Section for Biomedical Physics, Department of Radiation Oncology, University of Tübingen, Tübingen, Germany
  • Esther G.C. Troost

    10   Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
    11   OncoRay – National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany
    29   National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany
    30   German Cancer Consortium (DKTK), Partner Site Dresden, and German Cancer Research Center (DKFZ), Heidelberg, Germany
    35   Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiooncology – OncoRay, Dresden, Germany
  • on behalf of “Arbeitsgemeinschaft Nuklearmedizin und Strahlentherapie der DEGRO und DGN”
Preview

Abstract

This comprehensive review written by experts in their field gives an overview on the current status of incorporating positron emission tomography (PET) into radiation treatment planning. Moreover, it highlights ongoing studies for treatment individualisation and per-treatment tumour response monitoring for various primary tumours. Novel tracers and image analysis methods are discussed. The authors believe this contribution to be of crucial value for experts in the field as well as for policy makers deciding on the reimbursement of this powerful imaging modality.

Zusammenfassung

Diese umfassende Übersichtsarbeit, die von Experten auf ihrem Gebiet verfasst wurde, zeigt den aktuellen Stand hinsichtlich der Einbeziehung der Positronen-Emissions-Tomografie (PET) in die Strahlenbehandlungsplanung. Darüber hinaus werden laufende Studien zur Behandlungsindividualisierung und zur Überwachung des Tumoransprechens pro Behandlung bei verschiedenen Primärtumoren vorgestellt. Neuartige Tracer und Bildanalyseverfahren werden diskutiert. Die Autoren sind der Meinung, dass dieser Beitrag sowohl für Experten auf diesem Gebiet als auch für politische Entscheidungsträger, die über die Kostenerstattung dieser leistungsstarken Bildgebungsmodalität bestimmen, von entscheidendem Wert ist.

* This article is co-published in the journals Strahlentherapie und Onkologie and Nuklearmedizin – Nuclear Medicine Molecular Imaging and Therapy. https://doi.org/10.1007/s00066-021-01812-2 or https://doi.org/10.1055/a-1525-7029.




Publication History

Received: 30 May 2021

Accepted: 08 June 2021

Article published online:
14 July 2021

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