Synthesis of (S)-4-Methyl-3,6-dihydro-2H-pyran-2-carbaldehyde by Two-directional Ring Closing Metathesis: Application to the C27-C15-Fragment of Laulimalide

Abstract

Aldehyde 2, which is a key fragment in the synthesis of the antitumor agent laulimalide has been prepared from inexpensive d-mannitol via two-directional ring closing metathesis.

Key words

antitumor agent - two-directional synthesis - ring closing metathesis - glycol cleavage - tetraolefin

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