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Synfacts 2024; 20(05): 0483
DOI: 10.1055/s-0043-1763921
DOI: 10.1055/s-0043-1763921
Metals in Synthesis
Cross-Electrophile Coupling Enabled by Visible-Light Palladium Catalysis
Maiti S,
Ghosh P,
Raja D,
Ghosh S,
Chatterjee S,
Sankar V,
Roy S,
Lahiri GK,
Maiti D.
*
Indian Institute of Technology Bombay, Mumbai, India
Light-Induced Pd Catalyst Enables C(sp 2)–C(sp 2) Cross-Electrophile Coupling Bypassing the Demand for Transmetalation.
Nat. Catal. 2024;
7: 285-294
DOI: 10.1038/s41929-024-01109-4.
Light-Induced Pd Catalyst Enables C(sp 2)–C(sp 2) Cross-Electrophile Coupling Bypassing the Demand for Transmetalation.
Nat. Catal. 2024;
7: 285-294
DOI: 10.1038/s41929-024-01109-4.
Significance
Maiti and co-workers report a highly chemoselective cross-coupling of (hetero)aryl halides under palladium visible-light catalysis. Key to success was ligand design enabling differing modes of oxidative addition between the (pseudo)halides.
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Comment
Support for the proposed hybrid aryl Pd(I)-radical species was achieved by trapping the corresponding species with N-methyl pyrrole and DMPO. The corresponding DMPO adduct was subsequently characterized by EPR.
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Publication History
Article published online:
15 April 2024
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