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Synthesis 2011(15): 2490-2494
DOI: 10.1055/s-0030-1260109
DOI: 10.1055/s-0030-1260109
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New YorkRevisited Synthesis of Aryl-H-phosphinates
Further Information
Received
19 April 2011
Publication Date:
14 July 2011 (online)
Publication History
Publication Date:
14 July 2011 (online)
Abstract
A systematic study of the reaction conditions for the preparation of pure aryl-H-phosphinate esters, originally developed by Sander and optimized by Petneházy, is reported. The influence of the reaction concentration has been investigated for the formation of phosphonite intermediates via direct addition of triethyl phosphite to the appropriate Grignard reagent. Subsequent hydrolysis of the phosphonites under acidic conditions gives various aryl-H-phosphinates in high yields and purities.
Key words
phosphonites - phosphinates - aryl-H-phosphinates - triethyl phosphite - hydrolysis - Grignard reagent
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