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Synfacts 2008(7): 0665-0665  
DOI: 10.1055/s-2008-1077864
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (-)-Kaitocephalin

Contributor(s): Philip Kocienski, Arndt W. Schmidt
R. G. Vaswani, A. R. Chamberlin*
University of California-Irvine, USA
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Publication History

Publication Date:
20 June 2008 (online)

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Significance

(-)-Kaitocephalin is the first naturally occurring glutamate receptor antagonist. A scalable synthesis is reported. All five stereogenic centers are introduced diastereoselectively and their construction is discussed in depth.