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Synfacts 2008(4): 0386-0386
DOI: 10.1055/s-2008-1042871
DOI: 10.1055/s-2008-1042871
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York
Cobalt-Catalyzed Diastereoselective Reductive Mannich Reaction of Amides
O. Prieto, H. W. Lam*
University of Edinburgh, UK
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
19. März 2008 (online)
Significance
Earlier, the authors have reported the aldol reactions of zinc enolate generated via conjuate reduction by treatment of α,β-unsaturated amides with diethylzinc and a substoichiometric quantity of a cobalt salt (Org. Lett. 2006, 8, 3729). This present study reports Mannich reactions between aldimines and zinc enolates generated by conjugate reduction. Although yields and diastereoselectivities were moderate, it is noted that anti products were obtained as the major isomers.