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Am J Perinatol 1994; 11(3): 220-222
DOI: 10.1055/s-2008-1040750
ORIGINAL ARTICLE

© 1994 by Thieme Medical Publishers, Inc.

Predicting Oliguria Following Indomethacin for Treatment of Patent Ductus Arteriosus

Keith J. Barrington, Miriam Fox
  • Division of Newborn Medicine, Department of Pediatrics, University of Alberta, Edmonton, Alberta
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Publication Date:
04 March 2008 (online)

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ABSTRACT

Fifty-two consecutive infants who received intravenous indomethacin, 0.2 mg/kg, were reviewed to determine factors associated with the occurrence of oliguria. Serum creatinine and concentration prior to indomethacin did not predict the occurrence of oliguria. A mean urine output of less than 4.5 mL/kg/hr prior to the administration of indomethacin was the only factor that we determined to be associated with a significant risk of oliguria. Two infants developed symptomatic oliguria and both had a preindomethacin urine output less than 1.5mL/kg/hr.