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Synfacts 2008(1): 0062-0062  
DOI: 10.1055/s-2007-991479
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Novel Carbene Ligands for the Synthesis of Chiral Oxindoles

Contributor(s): Mark Lautens, Michael Langer
E. P. Kündig*, T. M. Seidel, Y.-X. Jia, G. Bernardinelli
University of Geneva, Switzerland
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Publication History

Publication Date:
18 December 2007 (online)

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Significance

Oxindole derivatives are interesting targets as potential pharmaceuticals. Few examples can be found for the synthesis of highly enantioenriched 3,3-disubstituted oxindoles (J. F. Hartwig and co-workers: J. Org. Chem. 2001, 66, 3402). The authors report on the synthesis of carbene ligands from readily available chiral starting materials and their use in the synthesis of highly enantioenriched oxindoles.