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Horm Metab Res 2007; 39(8): 582-588
DOI: 10.1055/s-2007-984480
Original Basic

© Georg Thieme Verlag KG Stuttgart · New York

The Administration of Oleoyl-estrone to Lactating Dams Induces Selective Changes in the Normal Growth Pattern of their Pups

B. García-Peláez 1 , R. Vilà 1 , X. Remesar 1
  • 1Departament de Nutrició i Bromatologia, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
Further Information

Publication History

received 29.11.2006

accepted 19.02.2007

Publication Date:
21 August 2007 (online)

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Abstract

To determine the effects of oleoyl-estrone treatment on the lactating dams and on the growth pattern of developing rats, female Wistar rats were randomly divided into two groups after delivery. One group received a daily gavage of 0.2 mL sunflower oil containing 10 μmol oleoyl-estrone/kg (treated group) and the other received a daily intragastric gavage of 0.2 mL sunflower oil (control group). Treatment was carried out during the first 15 days of lactation. Dams were killed on days 1, 15 or 20 after delivery and pups were sacrificed on days 1, 15, 20 or 30. Treated dams showed a transient decrease in food intake, significant lower lipid content than control dams, with a parallel maintenance of protein content and no appreciative changes in plasmatic parameters. However, a significant increase in brown adipose tissue mass was detected in treated group. Pups from treated dams showed a decrease in their growth rate that was reflected in the lower adipose tissue mass in different locations, except in the case of brown adipose tissue and, that continued after cessation of treatment. Thus, treatment affects dams in a selective way that does not coincide with a simple food restriction model.

Key words

Lactating rats - oleoyl-estrone - development

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Correspondence

Prof. X. Remesar

Departament de Nutrició i Bromatologia

Facultat de Biologia

Universitat de Barcelona

Av. Diagonal 645

08028 Barcelona

Spain

Phone: +34/93/402 15 18

Fax: +34/93/403 70 64

Email: xremesar@ub.edu

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