Horm Metab Res 2007; 39(7): 524-528
DOI: 10.1055/s-2007-984396
Original Clinical

© Georg Thieme Verlag KG Stuttgart · New York

Obesity and Attenuated Adiposity Rebound in Children with Congenital Hypothyroidism. Normalization of BMI Values in Adolescents

S. Livadas 1 [*] , M-A. Magiakou 1 [*] , C. Mengreli 2 , P. Girginoudis 2 , C. Galani 1 , P. Smyrnaki 1 , C. Kanaka-Gantenbein 1 , P. Xekouki 1 , G. P. Chrousos 1 , C. Dacou-Voutetakis 1
  • 1Endocrine Unit, First Department of Pediatrics, “Agia Sophia” Children's Hospital, Athens University Medical School, Greece
  • 2Institute of Child Health, “Agia Sophia” Children's Hospital, Athens, Greece
Weitere Informationen

Publikationsverlauf

received 22. 6. 2006

accepted 3. 1. 2007

Publikationsdatum:
05. Juli 2007 (online)

Abstract

An earlier adiposity rebound, suggestive of adult obesity, has been reported in children with congenital hypothyroidism. We undertook this study to evaluate the effect of congenital hypothyroidism on: 1) the timing of adiposity rebound, 2) the long-term prognosis of BMI status, and 3) the factors potentially affecting adiposity in subjects with congenital hypothyroidism. We found that in children with congenital hypothyroidism the BMI values were higher during the first years of life compared to normal population, but subsequently normalized. After the initial rise of BMI, the decline (nadir) and subsequent rise (adiposity rebound), usually occurring in normal children at an age greater than 30 months, was less evident in our group of children with congenital hypothyroidism. The severity of hypothyroidism affected BMI values at 6 and 12, but not at 36 months of age. In conclusion, in children with congenital hypothyroidism, 1) the high BMI values in early childhood normalize in adolescence, and 2) the normally expected BMI fluctuations during the first years of life are attenuated. These findings constitute indirect evidence that thyroid function during fetal and neonatal life affects BMI status during the first years of life.

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1 The first two authors have contributed equally to this paper.

Correspondence

M-A. Magiakou

Endocrine Unit

First Department of Pediatrics

“Agia Sophia” Children's Hospital

Athens University Medical School

Greece

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