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Planta Med 1986; 52(5): 406-407
DOI: 10.1055/s-2007-969201
Communications

© Georg Thieme Verlag Stuttgart · New York

Effects of Soyasaponins on Liver Tyrosine Aminotransferase Activity Induced by Cortisone in Adrenalectomized Rats

Hiromichi Okuda1 , Yoshiyuki Kimura1 , Mitsuyoshi Hashimoto1 , Shigeru Arichi2
  • 12nd Department of Medical Biochemistry, School of Medicine, Ehime University, Shigenobu-cho, Onsen-gun, Ehime 791-02, Japan.
  • 2The Research Institute of Oriental Medicine, Kinki University, Sayama-cho, Minamikawachi-gun, Osaka 589, Japan.
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Publikationsverlauf

1986

Publikationsdatum:
26. Februar 2007 (online)

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Abstract

It is well known that liver tyrosine aminotransferase activity is induced by administration of steroids to adrenalectomized rats. When total soyasaponins were injected intraperitoneally into adrenalectomized rats, liver tyrosine aminotransferase activity was not found to be induced. Administration of a low dose of cortisone (2.5 mg/kg body weight) to adrenalectomized rats also failed to induce liver tyrosine aminotransferase. On the other hand, this enzyme was found to be induced by administration of this low dose of cortisone with total soyasaponins (100 mg/kg body weight).

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