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Planta Med 1986; 52(2): 135-138
DOI: 10.1055/s-2007-969099
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© Georg Thieme Verlag Stuttgart · New York

Studies on Coumarins of a Chinese Drug “Qian-Hu”; VII1. Structures of New Coumarin-Glycosides of Zi-Huan Quian-Hu and Effect of Coumarin-Glycosides on Human Platelet Aggregation

Y. Matano2 , T. Okuyama2 , S. Shibata2 , M. Hoson3 , T. Kawada3 , H. Osada3 , T. Noguchi3
  • 2Department of Pharmacognosy and Phytochemistry, Meiji College of Pharmacy, Nozawa 1-35-23, Setagaya-ku, Tokyo, Japan
  • 3The Third Department of Surgery, St. Marianna University School of Medicine, Sugao 2095, Miyamae-ku, Kawasaki-shi, Japan
1 Part VI of this series: Kawasaki, C., Okuyama, T., Shibata, S., Iitaka, Y. (1984) Planta Med. 50, 492.
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Publication History

1985

Publication Date:
26 February 2007 (online)

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Abstract

Three kinds of new coumarin-glycosides, decuroside I (1), decuroside II (2), decuroside III (3), which were isolated from the n-butanol extracts of the crude drug Zi-Hua Qian-Hu, the root of Peucedanum decursivum Maxim. (Umbelliferae), were elucidated to be nodakenetin-4′-O-β-gentiobiose, nodakenetin-4′-Oβ-isomaltose and nodakenetin-4′-O-β-maltose, respectively, by the methods of chemical and spectral analysis.

These three new compounds as well as decuroside IV (4), decuroside V (5) and nodakenin (6) which were also isolated from Zi-Hua Qian-Hu were tested on human platelet aggregation induced by 2 µM ADP.

Among these coumarin-glycosides, 3 and 4, showed the strongest inhibiting activity against the primary and secondary wave aggregation of human platelet. 1 and 2 had a less inhibiting effect or none at all, and 5 was rather promotive against the primary wave aggregation.

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